Mortality Due to Nosocomial Infection with Klebsiella pneumoniae ESBL+

Abstract

Klebsiella pneumoniae is one of the most important hospital pathogens, particularly concerning the multidrug-resistant strain ESBL. The aim of this study was to evaluate nosocomial infections with K. pneumoniae ESBL in the context of infection location, risk factors, and prognosis. This hospital study was conducted retrospectively and covered a 3 months' period. The infection with K. pneumoniae ESBL was diagnosed in 36 patients (19 women and 17 men) of the mean age of 74.2 ± 14.8 years. The number of infected patients amounted to 2.2% of all patients admitted to Czerniakowski Hospital in Warsaw, Poland, over the study time. Twenty of these patients died (13 women and 7 men), representing 14% of all hospital deaths at the time. The infection with K. pneumoniae ESBL occurred most frequently in the department of internal diseases, and rarely in neurology or intensive care wards. Bacteria was most often isolated from the urine, with the most distinct association between the use of urinary catheters and death (p = 0.019). We conclude that infections with K. pneumoniae ESBL were associated with over 55% mortality and usually occurred in the setting of internal diseases. Deaths due to K. pneumoniae ESBL infection were significantly related to the use of urinary bladder catheters.

Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage

“…It has recently been demonstrated that Klebsiella is capable of exploiting pioneer communities in the premature infant gut and establishes during later periods of microbial succession ( Rao et al., 2021 ), though the mechanisms underlying this remain unknown. Klebsiella has previously been associated with sepsis, necrotizing enterocolitis (NEC), and nosocomial infections in neonates ( Starzyk-Łuszcz et al., 2017 ; Wisgrill et al., 2019 ). Multidrug-resistant and hyper-virulent Klebsiella has emerged globally and is now a major cause of severe infections, particularly in immuno-compromised patients ( Lee et al., 2017 ).…”

Microbial and Antimicrobial Resistance Profiles of Microbiota in Common Carps (Cyprinus carpio) from Aquacultured and Wild Fish Populations

“…We presumed that this isolate was allochthonous, indicating its origin was probably associated with contaminated water from sewage or other waste-water sources. It is known that so called super-bugs, such as the carbapenem-and extended spectrum betalactamase-resistant Klebsella pneumoniae, as isolated in this case, are widespread throughout health care facilities and are bacteria causing hospital infections [26]. Such multi-resistant bacteria, particularly carbapenemase-producing Enterobacteriaceae, are well-known as widespread nosocomial infectious agents in Lithuania [27].…”

Detection of Klebsiella pneumonia DNA and ESBL positive strains by PCR-based CRISPR-LbCas12a system

“…To date, ESBL-producing K. pneumonia contributes to nearly 45% of K. pneumoniae nosocomial infections ( Miftode et al, 2021 ) and 43% in the intensive care unit ( Paterson et al, 2004 ; Calbo et al, 2011 ). More strikingly, ESBL-positive strains result in significantly higher mortality ( Miftode et al, 2021 ); a recent study reported that ESBL-producing K. pneumonia is associated with over 55% mortality ( Starzyk-Luszcz et al, 2017 ). Despite various genes encoding ESBLs, most ESBLs were derived from one or two amino acid substitutions of SHV-1 and TEM-1 ( Ramdani-Bouguessa et al, 2011 ; Ben Achour et al, 2014 ).…”