Mortality by Level of Emphysema and Airway Wall Thickness

Johannessen, Ane; Skorge, Trude Duelien; Bottai, Matteo; Grydeland, Thomas Blix; Nilsen, Roy Miodini; Coxson, Harvey O.; Dirksen, Asger; Omenaas, Ernst; Gulsvik, Amund; Bakke, Per

doi:10.1164/rccm.201209-1722oc

Cited by 181 publications

(174 citation statements)

References 32 publications

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“…Subsequent studies 54,55 , with smaller cohorts but longer follow-up time (4 versus 8 years) and with different AL severity observed a significant association of lung attenuation areas low attenuation area (% LAA) and the prognosis of the disease 54,55 . Patient selection and emphysema evaluation criteria (% LAA) make comparisons between studies difficult.…”

Section: Emphysema and Mortalitymentioning

confidence: 97%

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The Impact of Emphysema on Chronic Obstructive Pulmonary Diseases

Torres¹,

Casanova²

2017

BRN

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Emphysema is defined as an abnormal and permanent enlargement of the air spaces distal to the terminal bronchioles that is accompanied by destruction of the air space walls, with no obvious fibrosis (i.e. there is no fibrosis visible to the naked eye) and it is usually associated to tobacco smoking. Although it is included in the pathological definition of chronic obstructive pulmonary disease (COPD), not all COPD patients have emphysema and its impact on the clinical presentation and the natural history of the disease is variable. The present review will cover the prevalence of emphysema in COPD patients, its impact on the clinical presentation, association with comorbidities and the main outcomes of the disease: exacerbations, lung function decline and mortality. In this review, we will only evaluate the relationship of tobacco-related emphysema with COPD. (BRN Rev. 2017;3:235-46)

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Section: Emphysema and Mortalitymentioning

confidence: 97%

“…Johannessen et al 55 , have shown that the degree of emphysema predicts all-cause, respiratory and cardiovascular mortality in a population-based sample of subjects with and without COPD. Patients with a degree of emphysema…”

Section: Emphysema and Mortalitymentioning

confidence: 99%

The Impact of Emphysema on Chronic Obstructive Pulmonary Diseases

Torres¹,

Casanova²

2017

BRN

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“…In patients with α1-antitrypsin deficiency, density-based emphysema measurement has shown a superior accuracy in detecting worsening of emphysema, and therefore has been accepted as the effective diagnostic method for detecting disease progression (16). The CT density mask method was found to have an association with COPD mortality, and is reported to be a stronger predictive parameter for cardiac and respiratory mortality than global initiative for chronic obstructive lung disease (GOLD) staging (17,18). Patients with greater quantitative measures of emphysema were reported to have more rapid decline of PFT parameters (19).…”

Section: Emphysema Quantificationmentioning

confidence: 99%

Quantitative CT Imaging in Chronic Obstructive Pulmonary Disease: Review of Current Status and Future Challenges

Cho

Seo

Lee

et al. 2018

J Korean Soc Radiol

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Chronic Obstructive Pulmonary Disease (COPD) is a complex heterogeneous condition with various clinical and pathologic features. In recent years, technical advances in quantitative CT imaging have generated considerable interest because they can provide a more precise and objective assessment of COPD. Emphysema and small-airway disease, the two major components of COPD, and other comorbidities, including pulmonary vessel alterations, atherosclerosis, cachexia, and osteoporosis, can all be assessed by means of quantitative imaging parameters. Increasing numbers of studies provide promising reports indicating that such parameters are associated with clinical measures of disease severity, respiratory symptoms, COPD exacerbations, and mortality. Despite such optimistic results, there are still many obstacles to using this quantitative technology in everyday practice to manage COPD patients. In this article, we review the current technical status of quantitative CT assessment, emphasizing its clinical implications and limitations. We also discuss present challenges and the potential future role of quantitative CT imaging in assessing COPD.

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“…Recently, it was reported that the level of emphysema predicts all-cause mortality as well as respiratory and cardiovascular mortality in a population-based sample of subjects with and without COPD. Airway wall thickness is associated with respiratory mortality in those with severe emphysema [47]. This is a new point to measure the mortality risk and is substantially important for COPD assessment.…”

Section: ) Imagingmentioning

confidence: 99%

“…This phenotype usually has a lower BMI. The degree of dyspnea, intolerance to exercise, and hyperinflation are predictors of mortality [47].…”

Section: ) Phenotypes and Biomarkersmentioning

confidence: 99%