Mortality and Clinical Outcomes in HIV-Infected Children on Antiretroviral Therapy in Malawi, Lesotho, and Swaziland

Kabue, Mark; Buck, W Chris; Wanless, Sebastian; Cox, Carrie M.; McCollum, Eric D.; Caviness, A. Chantal; Ahmed, Saeed; Kim, Maria H.; Thahane, Lineo; Devlin, Andrew; Kochelani, Duncan; Kazembe, Peter N.; Calles, Nancy R.; Mizwa, M.; Schutze, Gordon E.; Kline, Mark W.

doi:10.1542/peds.2011-1187

Cited by 72 publications

(67 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Median CD4 + T cell percentage increased from 3.16 (IQR 1-18) % to 11.0 (IQR 2-32) %, whereas median CD4 + absolute cell count increased from 9.5 (IQR 3-176) cell/mm 3 to 419.5 (IQR 202-1428) cell/mm 3 . Baseline level of CD4 + cell count in our study was very low compared with other studies [15,[19][20][21][22], but this result was not much different from baseline levels from 8 sites in Asia [14]. After ART initiation, CD4…”

Section: Discussioncontrasting

confidence: 70%

Immunological outcomes after six months with first line antiretroviral therapy: a lesson from Yogyakarta, Indonesia

Pangarungan¹,

Arguni²

2018

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: More than 1,300 children aged 0-14 years were infected with HIV in Indonesia by 2016. Adequate antiretroviral therapy (ART) can increase nutritional and immunological status, reduce incidence of opportunistic infection and mortality caused by HIV infection. After ART initiation, the children's treatment response needs to be monitored with CD4 + cell count and Viral Load (VL) evaluation. In resourcelimited setting, clinical and immunological parameters can be used to evaluate ART outcomes. The aimed of this study to know immunological status of the patient after 6 months ART in Dr. Sardjito Hospital in Yogyakarta, Indonesia. Methodology: A retrospective study was conducted from January 2010 to May 2016. HIV-infected children aged 0-18 years who were given first-line ART at least 6 months were included in this study. Age when ART initiation, gender, residence, nutritional status, clinical staging based on WHO criteria, incidence of hospitalization, baseline CD4 + cell count and CD4 + cell count after 6 months of therapy, tuberculosis treatment, and ART regimens were collected from medical records. Data were entered and analyzed using SPSS version 20.0 Results: Thirty-five subjects were included in this study. Median CD4 + T cell percentage increased from 3.16 (IQR 1-18) % to 11.0 (IQR 2-32) %, whereas median CD4 + absolute cell count increased from 9.5 (IQR 3-176) cell/mm 3 to 419.5 (IQR 202-1428) cell/mm 3 . Conclusion: Immunologic conditions could improve even with very low levels of CD4 + T cell percentage and CD4 + absolute cell count. Monitoring immunologic conditions and adherence of children with ART are essential to improve treatment outcomes.

show abstract

Section: Discussioncontrasting

confidence: 70%

Immunological outcomes after six months with first line antiretroviral therapy: a lesson from Yogyakarta, Indonesia

Pangarungan¹,

Arguni²

2018

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…11 out of 83 (13.3%) children were ambulatory, one was bedridden, while the rest of the study subjects (85.5%) were in working functional status. The signs, symptoms and opportunistic infections were almost similar to those reported earlier from developed and developing countries, including India 11,17,22,23,24 , although small variations can be attributed to the wide spectrum of disease all over the world. Management of these infections should be ensured in the ART clinics.…”

supporting

confidence: 82%

“…Similar observations were made by number of researchers 13,18,19,20,21 who reported a significant proportion of children (started on HAART) to be suffering from moderate or severe form of disease (31% -76%). 11 out of 83 (13.3%) children were ambulatory, one was bedridden, while the rest of the study subjects (85.5%) were in working functional status.…”

supporting

confidence: 81%

Clinico-Social and Immunological Profile of Antiretroviral Naïve Children Living With HIV In Tertiary Care Hospital, Delhi

Verma

Acharya

Bachani

et al. 2017

SAARC J. Tuber. Lung Dis. HIV/AIDS

View full text Add to dashboard Cite

introduction: This study was undertaken to assess the clinical profile of children living with HIV at the time of their enrolment in an ART centre in Delhi. The study also attempts to understand association between clinical staging and immunological profile (CD4 count/percentage) in HIV infected children. The findings of this study may help policy makers to plan better health care of CLHIV in resource constrained country like India. The Objectives of the study were to assess the baseline clinico-social and immunological profile of HIV positive children before the start of Antiretroviral Therapy, to study clinicosocial and morbidity profile of HIV positive children at the time of their enrolment in ART centre and to study the association between immunodeficiency and clinical staging of CLHIV.

show abstract

“…It was estimated that earlier access to ART could have prevented 25% of HIV related death [8,9]. However, access to ART for children was only 12% among children under 15 years of age [1].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Predictors of Mortality among Children on Anti-Retroviral Therapy in Public Health Facilities of Arba Minch Town, Gamo Gofa Zone, Southern Ethiopia; Retrospective Cohort Study

Boti¹,

Debere²,

Enderis³

et al. 2017

Clinics Mother Child Health

View full text Add to dashboard Cite

show abstract

Mortality and Clinical Outcomes in HIV-Infected Children on Antiretroviral Therapy in Malawi, Lesotho, and Swaziland

Cited by 72 publications

References 25 publications

Immunological outcomes after six months with first line antiretroviral therapy: a lesson from Yogyakarta, Indonesia

Immunological outcomes after six months with first line antiretroviral therapy: a lesson from Yogyakarta, Indonesia

Clinico-Social and Immunological Profile of Antiretroviral Naïve Children Living With HIV In Tertiary Care Hospital, Delhi

Incidence and Predictors of Mortality among Children on Anti-Retroviral Therapy in Public Health Facilities of Arba Minch Town, Gamo Gofa Zone, Southern Ethiopia; Retrospective Cohort Study

Contact Info

Product

Resources

About