Mortality and Cancer Experience of Quebec Aluminum Reduction Plant Workers, Part 2: Mortality of Three Cohorts Hired on or Before January 1, 1951

Gibbs, Graham W.; Armstrong, Ben; Sevigny, Maurice

doi:10.1097/jom.0b013e318157d34a

Cited by 28 publications

(43 citation statements)

References 23 publications

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“…Studies of PAH exposure in humans have included cooked meat at high temperatures (Anderson et al, 2005;Sinha et al, 2005;Li et al, 2007;De Stefani et al, 2009), an aluminum smelter cohort (Friesen et al, 2007;Gibbs et al, 2007), consumption of fried chicken (BaP ∼5.4 mg/kg) and smoked dried beef (BaP ∼5.5 mg/kg), smokers inhaling daily ∼0.26 mg of BaP per pack of 20 cigarettes (Piccardo et al, 2010), and charcoal-broiled steak containing BaP levels of ∼9.0 mg/kg (http://www.atsdr.cdc.gov/toxprofiles/tp.asp? id5122&tid525).…”

Section: Discussionmentioning

confidence: 99%

Oral Benzo[a]pyrene: Understanding Pharmacokinetics, Detoxication, and Consequences—Cyp1Knockout Mouse Lines as a Paradigm

et al. 2013

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Benzo [a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH); this ubiquitous environmental carcinogenic agent is found in tobacco smoke, charcoal-grilled foods, and PAH-contaminated surfaces of roofs, playgrounds, and highways. Cytochrome P450 1 wild-type, Cyp1a2(2/2), Cyp1b1(2/2), or Cyp1a2/1b1(2/2) knockouts, and mice with Cyp1a1 expression deleted in hepatocytes can ingest large oral BaP doses (125 mg/kg/d) without apparent toxicity. Cyp1a1(2/2) and Cyp1a1/1a2(2/2) knockouts and mice with Cyp1a1 expression deleted in gastrointestinal (GI) tract epithelial cells develop immunotoxicity and die within 32 days, indicating that GI tract inducible CYP1A1 is absolutely required for detoxication of oral BaP. Cyp1a1/1b1(2/2) and Cyp1a1/1a2/1b1(2/2) mice are rescued from immunosuppression and early death due to absent metabolic activation of BaP by CYP1B1 in immune cells. Ten-fold lower oral BaP doses result in adenocarcinoma of the proximal small intestine (PSI) in Cyp1a1(2/2) mice; Cyp1a1/1b1(2/2) double-knockout mice show no PSI cancer but develop squamous cell carcinoma of the preputial gland duct (PGD). BaP-metabolizing CYP1B1 in the PSI and CYP3A59 in the PGD are the most likely candidates to participate in tumor initiation in the epithelial cells of these two tissues; oncogenes and tumor-suppressor genes upregulated and downregulated during tumorigenesis are completely different between these tissues. This "oral BaP Cyp1" mouse paradigm represents a powerful teaching tool, showing that gene-environment interactions depend on route-of-administration: the same oral, but not intraperitoneal, BaP exposure leads to dramatic differences in target-organ toxicity and tumor type as a function of dose and Cyp1 genotype.

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Section: Discussionmentioning

confidence: 99%

Oral Benzo[a]pyrene: Understanding Pharmacokinetics, Detoxication, and Consequences—Cyp1Knockout Mouse Lines as a Paradigm

et al. 2013

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“…2 Although not significantly in excess, the SMRs were higher in the 2000 to 2004 follow-up period for accidents/poisonings/violence, cancer of the pancreas, ill-defined cancers, non-Hodgkin lymphomas and cancers of lymphoid tissues, chronic rheumatic heart disease, and diseases of arteries, arterioles, and capillaries. When both follow-up periods were combined, none of these increases revealed new causes with significant excess mortality over the whole period 1950 to 2004.…”

Section: Discussionmentioning

confidence: 98%

“…Information on smoking habits was obtained from a variety of sources 2 and varied in quality and quantity by plant and period.…”

Section: Smoking Historiesmentioning

confidence: 99%

Mortality and Cancer Incidence in Aluminum Smelter Workers

Gibbs¹,

Busque

Duguay³

2014

Journal of Occupational &Amp; Environmental Medicine

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“…The metal sector includes installations for steel founding and aluminum production, two industrial activities classified by Fig. 1 Geographic distribution of cases, controls, industrial installations, and centroids in the four health areas and wind roses for the city of Gijon, for the period 1971-2000 (annual, January, andJuly) the IARC as implying a carcinogenic risk to humans (IARC 2012), and reported by some occupational and/or environmental studies as being associated with lung cancer (Benedetti et al 2001;Bosetti et al 2007;Gibbs et al 2007;Pershagen and Simonato 1990;Rodriguez et al 2000;Spinelli et al 2006). Nevertheless, our results-with few exceptions-failed to show any consistent excess risk around such industrial activities.…”

Section: Resultsmentioning

confidence: 99%

Lung cancer risk associated with residential proximity to industrial installations: a spatial analysis

López-Cima

García‐Pérez

Pérez‐Gómez

et al. 2013

Int. J. Environ. Sci. Technol.

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Lung cancer is the most common cause of cancer-related death and thus a major public health problem. While lung cancer frequency might be partially attributable to smoking habit and occupational exposure, the role of industrial pollution also needs to be assessed. To ascertain the possible effect of residential proximity to industrial installations on lung cancer risk in Asturias, an industrial region in Spain, taking into account the type of industrial activity and carcinogenic substances released. We conducted a hospital-based case-control study covering 700 lung cancer patients and 700 controls recruited in Asturias, matched individually by ethnicity, hospital, age, and sex. Distances were computed from the respective participants' residential locations to the 48 industrial facilities governed by the Integrated Pollution Prevention and Control Act 16/2002 and included in the European Pollutant Release and Transfer Register, and located in the study areas. Using logistic regression, odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were calculated and adjusted for sex, age, hospital area, tobacco consumption, family history of cancer, area of residence, and occupation. Excess risk of lung cancer was observed for individuals living near industrial installations (OR = 1.43; 95 % CI = 1.08-1.89), particularly metal industries (OR = 1.40; 95 % CI = 1.05-1.87), cement plants (OR = 4.81; 95 % CI = 1. 20-19.19), and shipyards (OR = 1.69; 95 % CI = 1.17-2.43). Residents living close to industrial facilities releasing dioxins displayed a high, though nonstatistically significant, excess risk of lung cancer (OR = 1.62; 95 % CI = 0.86-3.07). This study suggests a possible association between lung cancer risk and proximity to industrial installations, specifically metal industries, cement plants, and shipyards.

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Mortality and Cancer Experience of Quebec Aluminum Reduction Plant Workers, Part 2: Mortality of Three Cohorts Hired on or Before January 1, 1951

Cited by 28 publications

References 23 publications

Oral Benzo[a]pyrene: Understanding Pharmacokinetics, Detoxication, and Consequences—Cyp1Knockout Mouse Lines as a Paradigm

Oral Benzo[a]pyrene: Understanding Pharmacokinetics, Detoxication, and Consequences—Cyp1Knockout Mouse Lines as a Paradigm

Mortality and Cancer Incidence in Aluminum Smelter Workers

Lung cancer risk associated with residential proximity to industrial installations: a spatial analysis

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