Abstract:Brain tumor mortality was either due to chance in the early years or the cause of the brain tumors has been eliminated. Mortality due to liver cancer is higher than expected but only among men hired before 1950.
This study evaluated unique exposures and their relationship to brain cancer mortality in employees of a specialty chemical research facility. Following an exposure assessment that concerned compounds distinct to this facility, the authors conducted a cohort mortality study of 5,284 workers to assess mortality in reference to the general population and a nested case-control study to evaluate brain cancer risk associated with specific jobs and unique chemical exposures. Four hundred eighty-six deaths, including 14 brain cancer deaths, were identified. Overall mortality was lower than expected. Brain cancer mortality was elevated (standardized mortality ratio [SMR] = 2.02, 95% confidence interval [CI] = 1.11-3.40). Exposures to 5 specific chemical categories were assessed. Exploration of work history and the specific chemical exposures did not explain the brain cancer cases. No clear occupational etiology was identified.
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