Morris water maze overtraining increases the density of thorny excrescences in the basal dendrites of CA3 pyramidal neurons

Gómez-Padilla, Eurídice; Bello-Medina, Paola C.; León-Jacinto, Uriel; Orta‐Salazar, Erika; Quírarte, Gina L.; Ramírez‐Amaya, Víctor; Prado-Alcalá, Roberto A.; Dı́az-Cintra, Sofı́a

doi:10.1016/j.bbr.2019.112373

Cited by 8 publications

(5 citation statements)

References 46 publications

(66 reference statements)

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“…(Kodali et al 2016) conducted a greater number of days of MWT training and used longer trials. Overtraining of the MWT is known to increase mossy fiber plasticity (Ramírez-Amaya et al 1999) and increased complexity of CA3 dendrites (Gómez-Padilla and Bello-Medina 2019) This could possibly leading to a more robust circuit supporting the memory. Stronger training protocols can make memory more resistant to neurogenesis-induced forgetting (Akers et al 2014) and even to HPC lesions (Lehmann et al 2009;Sutherland, Sparks, and Lehmann 2010;Lehmann and McNamara 2011).…”

Section: Introductionmentioning

confidence: 99%

Adult neurogenesis mediates forgetting of multiple types of memory in the rat

Scott

Terstege

Roebuck

et al. 2021

Preprint

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The formation and retention of hippocampus-dependent memories is impacted by neurogenesis, a process that involves the production of new neurons in the dentate gyrus of the hippocampus. Recent studies demonstrate that increasing neurogenesis after memory formation induces forgetting of previously acquired memories. Neurogenesis-induced forgetting was originally demonstrated in mice, but a recent report suggests that the same effect may be absent in rats. Although a general species difference is possible, other potential explanations for these incongruent findings are that memories which are more strongly reinforced become resilient to forgetting or that perhaps only certain types of memories are affected. Here, we investigated whether neurogenesis-induced forgetting occurs in rats using several hippocampal dependent tasks including contextual fear conditioning (CFC), the Morris Water Task (MWT), and touchscreen paired associates learning (PAL). Neurogenesis was increased following training using voluntary exercise for 4 weeks before recall of the previous memory was assessed. We show that voluntary running causes forgetting of context fear memories in a neurogenesis-dependent manner, and that neurogenesis-induced forgetting is present in rats across behavioral tasks despite differences in complexity or reliance on spatial, context, or object memories. In addition, we asked whether stronger memories are less susceptible to forgetting by varying the strength of training. Even with a very strong training protocol in the CFC task, we still observed enhanced forgetting related to increased neurogenesis. These results suggest that forgetting due to neurogenesis is a conserved mechanism that aids in the clearance of memories.

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Section: Introductionmentioning

confidence: 99%

Adult neurogenesis mediates forgetting of multiple types of memory in the rat

Scott

Terstege

Roebuck

et al. 2021

Preprint

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“…After the positioning navigation experiment, we started the space exploration experiment for mice, removed the underwater platform while marking the location and placed the mice into the water from the second quadrant. The mice were then observed for the time spent in the quadrant and the number of platform crossings within 120 s ( Gómez-Padilla et al, 2020 ; Lissner et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Characterization and anti-aging activities of polysaccharide from Rana dybowskii Guenther

Li,

Zhao,

Wang

et al. 2024

Front. Pharmacol.

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Introduction:Rana dybowskii Guenther (RDG), as a traditional Chinese medicine, has been shown to have antioxidant effects. However, studies on the anti-aging effect of RDG are still limited.Methods: In this study, we prepared polysaccharides from the skin of RDG (RDGP) by hot water extraction, alcohol precipitation, ion-exchange chromatography and gel chromatography. The proteins were removed using the Sevage method in combination with an enzymatic method. The structural features were analyzed using high-performance gel permeation chromatography, β-elimination reaction and Fourier transform infrared spectra. The anti-aging effect of RDGP was investigated by using D-Gal to establish an aging model in mice, and pathological changes in the hippocampus were observed under a microscope.Results: We obtained the crude polysaccharide DGP from the skin of RDG, with a yield of 61.8%. The free protein was then removed by the Sevage method to obtain DGPI and deproteinated by enzymatic hydrolysis combined with the Sevage method to further remove the bound protein to obtain the high-purity polysaccharide DGPII. Then, DGPIa (1.03 × 105 Da) and DGPIIa (8.42 × 104 Da) were obtained by gel chromatography, monosaccharide composition analysis showed that they were composed of Man, GlcA, GalNAc, Glc, Gal, Fuc with molar ratios of 1: 4.22 : 1.55: 0.18 : 8.05: 0.83 and 0.74 : 1.78: 1: 0.28: 5.37 : 0.36, respectively. The results of the β-elimination reaction indicated the presence of O-glycopeptide bonds in DGPIa. The Morris water maze test indicated that mice treated with DGPIIa exhibited a significantly shorter escape latency and increased time spent in the target quadrant as well as an increase in the number of times they traversed the platform. Pathologic damage to the hippocampus was alleviated in brain tissue stained with hematoxylin-eosin. In addition, DGPIIa enhanced the activities of SOD, CAT, and GSH-Px and inhibited the level of MDA in the serum and brain tissues of aging mice.Discussion: These results suggest that RDGP has potential as a natural antioxidant and provide useful scientific information for anti-aging research.

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“…And their dendritic tree presents two distinct parts: the relatively short proximal basal dendrites originated from the base of the soma and the distal apical dendrites extended through a larger dendritic trunk 51 . The proximal dendrites of CA3 pyramidal cells receive input mainly from dentate gyrus (DG) granular neurons, whereas the distal dendrites receive inputs from the entorhinal cortex 52 . For CA1 pyramidal cells, their proximal dendritic projections are primarily from CA3 neurons, while the distal dendritic inputs are from the entorhinal cortex and the thalamic nucleus reuniens 53 .…”

Section: Methodsmentioning

confidence: 99%

“…51 The proximal dendrites of CA3 pyramidal cells receive input mainly from dentate gyrus (DG) granular neurons, whereas the distal dendrites receive inputs from the entorhinal cortex. 52 For CA1 pyramidal cells, their proximal dendritic projections are primarily from CA3 neurons, while the distal dendritic inputs are from the entorhinal cortex and the thalamic nucleus reuniens. 53 In both stellate and pyramidal cells, the morphology of dendritic trees seems to be related to the location and distribution of connected excitatory neurons, while the shape of soma seems to be related to the size and extended direction of dendritic branches, and there are great individual differences.…”

Section: Modeling Somamentioning

confidence: 99%

A soma‐synapses neuron model and FPGA implementation

Wang

Essaf

2023

Concurrency and Computation

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SummaryThe neuron model serves as the foundation for building a neural network. The goal of neuron modeling is to shoot a tradeoff between the biological meaningful and the implementation cost, so as to build a bridge between brain science knowledge and the brain‐like neuromorphic computing. Unlike previous neuron models with linear static synapses, the focus of this research is to model neurons with relatively detailed nonlinear dynamic synapses. First, a universal soma‐synapses neuron (SSN) is proposed. It contains a soma represented by a leaky integrate‐and‐fire neuron and multiple excitatory and inhibitory synapses based on ion channels dynamics. Short‐term plasticity and spike‐timing‐dependent plasticity linked to biological microscopic mechanisms are also presented in the synaptic models. Then, SSN is implemented on field‐programmable gate array (FPGA). The performance of each component in SSN is analyzed and evaluated. Finally, a neural network SSNN composed of SSNs is deployed on FPGA and used for testing. Experimental results show that the stimulus‐response characteristics of SSN are consistent with the electrophysiological test findings of biological neurons, and the activities of SSNN exhibit a promising prospect. We provide a prototype for embedded neuromorphic computing with a small number of relatively detailed neuron models.

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Morris water maze overtraining increases the density of thorny excrescences in the basal dendrites of CA3 pyramidal neurons

Cited by 8 publications

References 46 publications

Adult neurogenesis mediates forgetting of multiple types of memory in the rat

Adult neurogenesis mediates forgetting of multiple types of memory in the rat

Characterization and anti-aging activities of polysaccharide from Rana dybowskii Guenther

A soma‐synapses neuron model and FPGA implementation

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