Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections
Carlotta Barelli,
Flaminia Kaluthantrige Don,
Raffaele M Iannuzzi
et al.
Abstract:Glioblastoma is a major unmet clinical need characterized by striking inter- and intra-tumoral heterogeneity and a population of glioblastoma stem cells (GSCs), conferring aggressiveness and therapy resistance. GSCs communicate through a network of tumor-tumor connections (TTCs), including nanotubes and microtubes, promoting tumor progression. However, very little is known about the mechanisms underlying TTC formation and overall GSC morphology. As GSCs closely resemble neural progenitor cells during neurodeve… Show more
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