Morphometry of paravaginal ganglia from the pelvic plexus: impact of multiparity, primiparity, and pregnancy

Castelán, Francisco; Xelhuantzi, Nicte; Hernández-Aragón, Laura G; Rodríguez-Antolín, Jorge; Cuevas, Estela; Martı́nez–Gómez, Margarita

doi:10.1016/j.ejogrb.2013.07.008

Cited by 10 publications

(23 citation statements)

References 24 publications

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“…They are associated with increased concentrations of glucocorticoids and catecholamines [27]. Stress can excite catecholamines alpha receptors and cause vasoconstriction, thereby reducing uterusblood flow [9]. Second,Corticotropic-releasing hormone (CRH) activates the HPA axis when stress is present in the body.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Zhao showed that restraint-induced stress inhibits mouse implantation by impairing uterine receptivity and down regulating oestrogen (O) and progesterone (P) and heparin-binding epidermal growth factor (HB-EGF) [8]. Castelrn proposed that fertility stress affects uterine artery blood flow, consequently influencing IVF pregnancy outcomes [9]. However, few studies have used endometrial receptivity to address fertility stress when evaluating pregnancy outcomes.…”

Section: Introductionmentioning

confidence: 99%

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The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

Yan

Cai

Xing

et al. 2017

Reprod Biol Endocrinol

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BackgroundTo investigate the effect of fertility stress on endometrial and subendometrial blood flow among infertile women.MethodsThis case–control study was conducted in The First Affiliated Hospital of Zhengzhou University. The fertility problem inventory (FPI) was adopted to evaluate fertility stress. Three-dimensional power Doppler ultrasonography (3D PD-US) was performed during the proliferative phase of the menstrual cycle (days 5–11) to measure endometrial thickness, pattern, endometrial and subendometrial volume (V), the vascularization index (VI), the flow index (FI) and the vascularization-FI (VFI) index. Then, 300 infertile women were separated into two groups (high-score group and low-score group) based on total FPI scores and 80 healthy women were selected as controls.ResultsNo differences were found among all three groups with regard to general characteristics, endometrial thickness, pattern, endometrial and subendometrial V, VI and VFI. The endometrial and subendometrial FIs associated with different stress levels significantly differed among the three groups (F = 33.95, P < 0.001; F = 44.79, P < 0.001, respectively). The endometrial and subendometrial FIs in the control group were significantly higher than those in the high-score group and low-score groups. The endometrial and subendometrial FIs in the low-score group were significantly higher than those in the high-score group. The total FPI score was closely related to the endometrial and subendometrial FIs (r = −0.304, P < 0.001; r = −0.407, P < 0.001, respectively).ConclusionFertility stress was associated with endometrial and subendometrial flow index. Whether fertility stress might affect pregnancy outcome by reducing endometrial and subendometrial blood flow requires further research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

Yan

Cai

Xing

et al. 2017

Reprod Biol Endocrinol

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“…It also modifies the amount of collagen in the vagina and increases labor duration in goats (Das and Tomer, ). Additionally, it has been shown that multiparity alters the morphometry of paravaginal ganglia in rabbits (Castelán et al, ). This reproductive condition causes fibrosis of the endometrium and myometrium in mares (Grüninger et al, ; Esteller‐Vico et al, ).…”

Section: Introductionmentioning

confidence: 99%

Tissue alterations in urethral and vaginal walls related to multiparity in rabbits

Xelhuantzi

Rodríguez-Antolín

Nicolás

et al. 2014

The Anatomical Record

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In rodents, vaginal distention after delivery or experimental manipulation affects innervations as well as the amount of striated/smooth musculature or collagen in both the urethra and vagina. These changes are associated with modifications in excretory and reproductive processes. Although successive and consecutive vaginal deliveries (multiparity) affect the contractile and functional properties of the female lower urogenital tract (LUT), its impact on LUT morphometry, including persistency, has been barely studied. The caudal urethra (CU) and cranial (V1) and caudal (V2) pelvic vaginal regions were excised from young and adult nulliparous (YN and AN, respectively) and multiparous (YM and AM, respectively) rabbits. Tissues were histologically processed and stained with Masson's trichrome. The thickness of the tissue layers and areas covered by tissue components were measured and compared using two-way ANOVA followed by Student-Newmann-Keuls tests to determine statistical differences (P 0.05). Compared to YN, YM, and AN tissues showed a reduction in the thickness of the epithelium, as well as in areas covered by striated musculature, collagen, and blood vessels of the LUT. In comparison with YM, only some morphometric changes were recovered in the AM group. Our study shows that multiparity and age can be associated with epithelial and muscular atrophy of urethral and vaginal walls. The morphometry of the LUT between young and adult female rabbits varies with multiparity. These findings may help to better understand the effects of multiparity on young and adult females and its correlation with the development of pelvic dysfunctions. Anat Rec, 297:1963Rec, 297: -1970Rec, 297: , 2014

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“…Moreover, high immunolabeling for TRs and TSHR in neurons and glia of the paravaginal ganglia was observed. This ganglion is highly sensitive to variations in the concentration of gonadal hormones and their neurons have estrogen receptors (24). Thus, thyroid hormones and TSH could be able to affect the synaptic contacts of these ganglia cells.…”

Section: Discussionmentioning

confidence: 99%

“…To know the localization of TRs and TSHR in the female reproductive tissues could help to understand those mechanisms involved in the relationship between thyroid hormones and female reproduction. Our present study aimed to give a detailed description about the presence of TRα1-2 and -ß1, as well as TSHR immunostaining in the ovary, oviduct, uterus, and vagina of the rabbit, a species widely used for reproductive researching (23)(24). Additionally, the presence of these receptors was analyzed in other structures anatomically related to the lower urogenital tract, such as the paravaginal ganglia (24), levator ani and iliococcygeous muscles (25), clitoris, Skene's gland (female prostate) (26), and the perigenital skin.…”

Section: Introductionmentioning

confidence: 99%

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

et al. 2016

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Morphometry of paravaginal ganglia from the pelvic plexus: impact of multiparity, primiparity, and pregnancy

Cited by 10 publications

References 24 publications

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

Tissue alterations in urethral and vaginal walls related to multiparity in rabbits

Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

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