Morphometry and cytodiagnosis of breast lesions

Abstract

Cells aspirated from breast lesions and smeared on slides were subjected to computer assisted morphometric analysis. Three groups of cases were studied. The first were those collected from patients with known benign and malignant lesions. The second group were 143 unselected consecutive aspirates from breast lesions and the third, a group with a needle aspirate cytodiagnosis "suspicious of malignancy". The analysis showed the malignant cells to have larger nuclei with more anisokaryosis and more variation in the nuclear cytoplasmic ratios when compared with benign cells. When this form of semiautomatic analysis was applied to the "suspicious" group the accuracy of cytodiagnosis was improved.

Significance of nuclear morphometry in benign and malignant breast aspirates

“…[14] used nuclear/cytoplasmic ratio for characterizing cells of different tumors; however, Abdalla et al . [4] opined that such parameter to be avoid as outlining of cellular margins is difficult due to indistinct cytoplasmic outline than nuclear outline, thus making the analysis less reproducible and more subjective.…”

Breast Cancer: Computer Simulation Method for Estimating Optimal Intervals for Screening

“…The number of cells n in a tumor can be roughly estimated from the tumor diameter by using the expression n Ϸ B[4/3(d/2) 3 ], where d is the tumor diameter, and B is the number of cells per cubic centimeter. Because most tumors cells are roughly 20 µm in diameter (39)(40)(41), a B value of approximately 10 8 cells per cubic centimeter is a reasonable approximation, although, as will become apparent later, our model does not require a precise estimate of B. The probability that a cell will leave the primary tumor and form a distant metastasis is defined as 1/P, which is expressed in units of cell Ϫ1 · day Ϫ1 .…”

How cancer at the primary site and in the lymph nodes contributes to the risk of cancer death

“…[13][14][15] By using Equation 7, we have observed that, 3,7 for both lethal and nonlethal spread of breast carcinoma and melanoma, the value of p declines gradually as tumors increase in size, N, and indeed can be closely fit by a power function,…”