Morphometrisch-ultrastrukturelle Untersuchungen über die durch die Tageszeit induzierten Veränderungen der Rattenleberparenchymzelle

The rhythmic organization of Rodent Liver a review

“…Morphological (Müller et al, 1966) and morphometric studies have also indicated rhythmic changes of various cell structures including rough ER (Rohr et al, 1970): the relative amount of RER is higher at night (relative index 25.7) than at daytime (18.1), whereas the relative amount of smooth ER did not change significantly (23.0 : 23.7). Other semiquantitative estimates of the amount of RER and SER in different regions of rat liver reached different results (Ghedid and Nair, 1972): only in the midzonal area an increase of RER was observed at 22.00 hr, but in this area and in the central area a rhythmic increase in the amount of SER was observed at night.…”

Experimental protein-energy malnutrition in baby baboons

“…It is known that hepatocyte components, and especially glycogen, normally exhibit diurnal variation in quantity. All our biopsies were performed between 10.00 and 12.00 hours, when liver glycogen content is normally high (Rohr, Hundstad, Bianchi & Eckert, 1970). It is recognized, however, that phase shifts in diurnal rhythms may be influenced by diet (Fuller & Diller, 1970), and we plan to investigate the possible significance of this in our future experimental work.…”

The membrane association among the rough- and smooth-surfaced endoplasmic reticulum and Golgi apparatus in rat hepatocytes at certain circadian stages.

“…--membrane association; endoplasmic reticulm; Golgi apparatus; rat hepatocytes Corresponding to the dramatic change in glycogen content of hepatocytes during the 24-hr span, the volume densities of mitochondria and sER, and the distribution pattern of rER exhibit prominent circadian variations (Muller 1966;Rohr et al 1970;Uchiyama 1980Uchiyama , 1981Uchiyama and von Mayersbach 1981). The author (1981) clarified the relationship between ER and outer mitochondrial membranes through the tubular structure, which forms a bridge between the two organelles and whose incidence demonstrates a circadian change.…”