Perisesarma eumolpe, the dominant species living in the damaged area caused by Durian storm in the Can Gio mangrove forest, had the role of changing the sedimentary structures for easier plant regeneration, contributing to the growth and development of the small soil organisms and playing role in the natural process of mangroves. This paper presented the ecological population structure, seasonal structural changes, growth and development of this species. The investigation based on the size distribution, density, biomass, sex ratio, and reproductive rate of the population and restoration of the forest ecosystem were evaluated. These recorded a P. eumolpe total population of 6169 individuals, including 3749 males (accounting for 60.77%) and 2420 females (accounting for 39.23%). The ratio of male to female individuals was 1: 0.65. August was the month when the most egg-bearing females was recorded. The first time-egg-bearing female had a carapace with the size of 9 mm. The moulting of crabs took place at every month of the year where the highest molting rate was from October to March, and the lowest was in April. The carapace size of individuals in the intact forest area was larger than those in the damaged one (D2F > D1F > D2Hcut > D1Hcut > D1Hnat). The crab density ranged from 268 individuals (in September) to 639 individuals (June) per month. The crab biomass ranged from 504.09 g per month to 1161.03 g per month. The highest biomass was recorded in June (1161.03 g/month), followed by in August (1139.56 g/month), and in May had a total biomass of 1074.4 g/month. The population growth and the development had the tendency of early maturation at smaller sizes and increased individual density in fractured habitats. This was the way that the species adapt to the conditions of a natural forest regeneration.