“…7 The pattern of degeneration of anterior horn cells in the spinal cord is random, and there is no predilection for certain motor neuron cell columns, 13 although the C-8 segments tend to be preferentially involved in ALS. 12,14 The anterior horn cells to both the APB and ADM muscles are segmentally close and equal involvement of their respective motor neuron pools would be anticipated. However, the APB corticomotor neurons far outnumber those of the ADM, and the connections of the former are much more extensive than those of the latter.…”