Morphometric immunohistochemical examination of the inflammatory tissue reaction after implantation of calcium phosphate-coated titanium plates in rats

Walschus, Uwe; Hoene, Andreas; Neumann, Hava; Wilhelm, L.; Lucke, Silke; Lüthen, Frank; Rychly, Joachim; Schlosser, Michael

doi:10.1016/j.actbio.2008.09.003

Cited by 30 publications

(26 citation statements)

References 36 publications

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“…Musculature is also well perfused with blood and therefore especially suitable for examining inflammatory reactions. The simultaneous implantation of the four implants into the same individual animals as performed in this study was similar to previous experiments on calcium-phosphate-coated titanium [14]. The advantage of this approach is that it eliminates the broad individual variability of host reactions which were observed, for example, in studies on the immunological reactions against vascular prostheses using inbred rats as well as pigs [16,17].…”

Section: Discussionmentioning

confidence: 79%

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In vivo investigation of the inflammatory response against allylamine plasma polymer coated titanium implants in a rat model

et al. 2010

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Section: Discussionmentioning

confidence: 79%

“…For this purpose, an intramuscular implantation in Lewis rats was performed, which was previously established for calcium-phosphate-coated titanium implants [14]. Each animal simultaneously received a titanium control implant as well as three implants with different PPAAm coatings.…”

Section: Introductionmentioning

confidence: 99%

In vivo investigation of the inflammatory response against allylamine plasma polymer coated titanium implants in a rat model

et al. 2010

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“…Such application include bone contacting implants, which can be equipped with rough surfaces and hydroxylapatite coating to improve healing [7]. But, these surface modifications do not meet all needs of hip, knee, and dental implants made from titanium (Ti).…”

Section: Introductionmentioning

confidence: 99%

Gas-Discharge Plasma-Assisted Functionalization of Titanium Implant Surfaces

Schröder

Finke

Polák

et al. 2010

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Abstract.A crucial factor for in-growth of metallic implants in the bone stock is the rapid cellular acceptance whilst prevention of bacterial adhesion on the surface. Such contradictorily adhesion events could be triggered by surface properties. There already exists fundamental knowledge about the influence of physicochemical surface properties like roughness, titanium dioxide modifications, cleanness, and (mainly ceramic) coatings on cell and microbial behavior in vitro and in vivo.The titanium surface can be equipped with antimicrobial properties by plasma-based copper implantation, which allows the release and generation of small concentrations of copper ions during contact with water-based biological liquids.Additionally, the titanium surface was equipped with amino groups by the deposition of an ultrathin plasma polymer. This coating on the one hand does not significantly reduce the generation of copper ions, and on the other hand improves the adhesion and spreading of osteoblast cells.The process development was accompanied by physicochemical surface analyses like XPS, FTIR, contact angle, SEM, and AFM. Very thin modified layers were created, which are resistant to hydrolysis and delamination. These titanium surface functionalizations were found to have either an antimicrobial activity or cell-adhesive properties. Intramuscular implantation of titanium samples coated with the cell-adhesive plasma polymer in rats revealed a reduced inflammation reaction compared to uncoated titanium.

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“…It exists in a variety of different chemical preparations differing in their atomic and ionic lattice configuration, their Ca:P ratio, the number and size of pores, and their surface area. One calcium phosphate preparation commonly used for biomaterials is hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) which is generally considered to be osteoconductive and osteoinductive (Walschus et al, 2009). Using a process called plasma spraying, it is possible to deposit thin and dense layers of hydroxyapatite onto metal implant surfaces (de Groot et al, 1987).…”

Section: Creation Of Bioactive Surfacesmentioning

confidence: 99%