Morphometric grading of bladder tumors in comparison with histologic grading by pathologists

Ooms, E. C. M.; Kurver, P.H.J.; Veldhuizen, R. W.; Alons, C. L.; Boon, Mathilde E.

doi:10.1016/s0046-8177(83)80243-3

Cited by 82 publications

(35 citation statements)

References 16 publications

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“…The morphometric parameters of nuclear areas in our series were similar to that observed by Ooms et al [11]. We also examined the nuclear length axis, breadth axis, axis ratio and area ratio.…”

Section: Discussionsupporting

confidence: 85%

Morphometric Diagnosis of Bladder Tumor

Yangzhi¹,

Wang²,

Wang³

et al. 1991

Oncology

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This paper reports the morphometric analysis results of 100 cases of bladder tumor cells with a Q-900 computer-assisted image analysis system. According to the nuclear area, axis ratio and area ratio of tumor nuclei, bladder transitional cell tumors were divided into 4 grades. This system is called the morphometric grading system (M grading). The results show that the higher the M grading, the lower the survival rate and the higher the recurrence rate. As the M grade increases the tumors could be accompanied by muscular invasion. When recurring, the tumor has a poor prognosis if M grading increases. We conclude that the morphometric grading system is able to yield a quantitative pathologic diagnosis and can predict the biological behavior of bladder tumors. Recently, new techniques for diagnosing and predicting the biological behavior of bladder tumors have been developed. One such technique is morphometric analysis of bladder transitional cell carcinoma with computer-assisted image instruments [1]. Because this morphometric method is easily applicable to pathological section routinely stained with HE and the results are reproducible and more objective, the studies about morphometric analysis of bladder tumor have increased in recent times. This paper reports the preliminary morphometric analysis results of bladder tumor cells examined by a Q-900 image analysis instrument for 100 cases.

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Section: Discussionsupporting

confidence: 85%

Morphometric Diagnosis of Bladder Tumor

Yangzhi¹,

Wang²,

Wang³

et al. 1991

Oncology

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“…Initial successful morphometrical analyses were applied to hepatocellular carcinoma (42) and malignant lymphomas (43,44) with the aim of distinguishing them from benign lesions by measuring mean nuclear size. Similar approaches have been found useful in evaluating the differences between low-grade and high-grade malignant tumors of the breast (45) and bladder cancers (46,47), as well as some subtypes of malignant lymphoma (48).…”

Section: Morphometrymentioning

confidence: 89%

Atypical Adenomatous Hyperplasia of the Lung: A Probable Forerunner in the Development of Adenocarcinoma of the Lung

et al. 2001

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An increasingly large body of work suggests that atypical adenomatous hyperplasia (AAH) of the lung may be a forerunner of pulmonary adenocarcinoma. Recognizing this fact, the World Health Organization now acknowledges the existence of AAH while noting difficulties that may be encountered in distinguishing AAH from the nonmucinous variant of bronchioloalveolar carcinoma. Regrettably, a universally acceptable definition of morphologic criteria for the diagnosis of AAH has not been achieved. This review of the literature examines the epidemiology, gross appearance, light microscopic findings, morphometry, immunohistochemistry, and molecular features of AAH and suggests a set of histopathologic features that may help the practicing pathologist identify this intriguing lesion. These features include the following: irregularly bordered focal proliferations of atypical cells spreading along the preexisting alveolar framework; prominent cuboidal to low columnar alveolar epithelial cells with variable degree of atypia but less than that seen in adenocarcinoma; increased cell size and nuclearcytoplasmic ratio with hyperchromasia and prominent nucleoli, generally intact intercellular attachment of atypical cells with occasional empty-looking spaces between them without high cellularity and without tufting or papillary structures; and slight thickening of the alveolar walls on which the AAH cells have spread, with some fibrosis but without scar formation or significant chronic inflammation of the surrounding lung tissue. Several lines of evidence indicate that AAH is a lesion closely associated with adenocarcinoma of the lung, suggesting AAH may be involved in the early stage of a complex multistep carcinogenesis of pulmonary adenocarcinoma.

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“…Histological grading of transitional cell tumors of the urinary bladder has an important place in clinical prac tice [1][2][3][4], However, histological grading suffers from lack of reproducibility [5]. This is why more objective methods have been tested to show their potential value in grading.…”

Section: Introductionmentioning

confidence: 99%

“…This is why more objective methods have been tested to show their potential value in grading. These include cytogenetic methods [6,7], morphometry [5,[8][9][10], and DNA or RNA flow cytom etry (FCM) [11][12][13][14][15][16][17][18], The nuclear DNA content of many malignant tumors shows an association with prognosis, and usually euploid tumors correlate with a better prog nosis than aneuploid ones [12,[19][20][21], but no firm con clusions of the practical clinical value of the measure ments have been established. Of special interest to histopathologists is the question whether ploidy determina tion from paraffin blocks could help in grading or predic tion of outcome.…”

Section: Introductionmentioning

confidence: 99%

DNA Ploidy and S Phase Fraction in Human Bladder Cancer

Lipponen¹,

Eskelinen²,

Collan³

et al. 1990

Urol Int

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The nuclear DNA content of archival paraffin-embedded bladder cancer samples (70 patients) of WHO grades I–III has been measured by flow cytometry. The female/male ratio was 15/55. The mean follow-up time was 13 years (range 9.6–22.0 years). 37 of 70 (53%) patients had DNA index 1.0 (diploid DNA content), and the remaining 33 (47%) patients had an aneuploid tumor. There was no significant difference in the age (mean ± SD) of the patients having a diploid (66 ± 9 years) or an aneuploid tumor (68 ± 11 years) at the time of diagnosis. 47 deaths occurred during the follow-up period; 24 (51%) of these were due to bladder cancer (12 diploid, 12 aneuploid tumors). No significant difference was found after radical treatment during the disease-free interval (mean ± SD) between diploid (48 ± 45 months) and aneuploid (35.5 ± 35 months) groups of patients. Recurrences during the follow-up period were equally common among aneuploid and diploid tumors. A statistically significant relation between histological grade and survival could be demonstrated, but DNA ploidy and S phase fraction had little prognostic value in this respect. There was no statistically significant difference in survival between aneuploid (30%) and diploid (35%) groups of tumors during the follow-up period. The study suggests that flow cytometric determination of nuclear DNA ploidy from paraffin-embedded samples in bladder tumors does not add to the prognostic power of subjective histological grading.

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Morphometric grading of bladder tumors in comparison with histologic grading by pathologists

Cited by 82 publications

References 16 publications

Morphometric Diagnosis of Bladder Tumor

Morphometric Diagnosis of Bladder Tumor

Atypical Adenomatous Hyperplasia of the Lung: A Probable Forerunner in the Development of Adenocarcinoma of the Lung

DNA Ploidy and S Phase Fraction in Human Bladder Cancer

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