Morphometric evaluation of the hydrocephalic brain: relationships with cognitive development

Fletcher, Jack Μ.; Bohan, Timothy P.; Brandt, Michael E.; Kramer, Larry A.; Brookshire, Bonnie L.; Thorstad, Kelly; Davidson, Kevin C.; Francis, D.; McCauley, Stephen R.; Baumgartner, James E.

doi:10.1007/bf00301250

Cited by 62 publications

(56 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three measures previously correlated with area measurements of the CC (Fletcher et al, 1996) were used for this study: Stanford-Binet Test of Intelligence (Thorndike et al, 1986), Purdue Pegboard (Tiffin, 1968), and dichotic listening (Hannay et al, 2008).…”

Section: Neurobehavioral Measuresmentioning

confidence: 99%

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

et al. 2014

Self Cite

View full text Add to dashboard Cite

Although there are many studies of people with complete or partial hypogenesis of the corpus callosum (CC), little is understood about the hypoplastic CC in which all structures are present but thinned. Spina bifida myelomeningocele (SBM) is a model organism for such studies because many have either a hypogenetic or hypoplastic CC. We used diffusion tensor tractography (DTT) to evaluate the hypoplastic CC in SBM and its relation to interhemispheric functions and intelligence quotient (IQ). Participants were individuals with SBM and an intact or hypoplastic CC (n = 28), who were compared to a typically developing comparison group (n = 32). Total and regional DTT volume and integrity measures (fractional anisotropy, axial diffusivity, and radial diffusivity) of the CC were related to measures of intelligence (IQ), bimanual motor functioning, and dichotic auditory performance. As predicted, DTT showed variations in volume and integrity that were maximized in the entire CC and the posterior CC. IQ correlated with entire CC volume, anterior and posterior regional CC volumes, and also with measures of integrity. Bimanual motor functioning correlated with the anterior and posterior volumes of the CC but not with any integrity measures. Axial diffusivity in the posterior CC was negatively correlated with right ear dichotic listening performance. The hypoplastic CC is not macrostructurally or microstructurally intact in SBM, even when it appears radiologically intact. Both volume and integrity of the posterior regions were related to reductions in IQ and to interhemispheric processing. These findings may transfer to other disorders characterized by a hypoplastic CC.

show abstract

Section: Neurobehavioral Measuresmentioning

confidence: 99%

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Children suffering from hydrocephalus often present a retarding in the development of their cognitive functions, with a tendency of showing more faults in the development of nonverbal cognitive functions than in the development of speech 10,11,12,13 . Rare studies have associated these alterations of the nonverbal cognitive functions with a degree of exposure of the corpus callosum and of periventricular white matter in the hydrocephalus.…”

Section: Introductionmentioning

confidence: 99%

Study of corpus callosum in experimental hydrocephalic wistar rats

2003

View full text Add to dashboard Cite

PURPOSE: Hydrocephalus causes countless cerebral damages, especially on the structures around the ventricles. Hydrocephalic children present deficiencies in the nonverbal skills more than in the verbal skills, and not always revertible with an early treatment. As the corpus callosum has an important role in the nonverbal acquisition it is possible that the injuries in this structure are responsible for the cognitive dysfunctions of these children. This present study tries to establish the alterations caused by hydrocephalus on the corpus callosum of developing Wistar rats, induced by intracisternal injection of kaolin. METHODS : Seven, fourteen and twenty one days after the injection, the animals were killed, and the corpus callosum was dissected and prepared for the study of the axonal fibers. RESULTS AND CONCLUSION: The seven-day old rats in hydrocephalus development presented a delay in myelination in relation to the control rats. With the fourteen-day old rats in hydrocephalus development the corpus callosum showed a recovery of myelin, but with the twenty one-day old rats in hydrocephalus development the axonal fibers were damaged and reduced in number.

show abstract

“…16,18 The association between decreased QOL outcome and larger ventricle size is not so easily explained. In children with hydrocephalus, some studies have observed an association between ventricle size and specific brain morphometric and cognitive changes, [8][9][10] but others have found no association with overall QOL outcome. 21,23 It is possible that a large current ventricular size is a marker for long-standing hydrocephalus prior to presentation (and, thus, for ventriculomegaly that is less likely to fully normalize after treatment).…”

Section: Discussionmentioning

confidence: 99%

Long-term quality of life in children treated for posterior fossa brain tumors

Kulkarni¹,

Piscione

Shams³

et al. 2013

PED

View full text Add to dashboard Cite

Object In the face of increasing survival, quality of life (QOL) has become an important indicator of treatment success in children with posterior fossa brain tumors (PFBTs). The authors' objective was to assess the long-term QOL in survivors of PFBT. Methods The authors conducted a cross-sectional study of children who, between birth and age 18 years at diagnosis, had previously been treated at their institution for a PFBT. At the time of assessment for this study, children were between 5 and 19 years old and had received standard treatment for PFBT ending at least 6 months before the assessment. The QOL was measured with the Pediatric Quality of Life Inventory (PedsQL) generic score scales and the Health Utilities Index Mark 3 (HUI3). Multivariate analyses were used to assess several variables (patient related, treatment related, and socioeconomic) for association with QOL. Results A total of 62 children participated in the study (median age at assessment 11.9 years, interquartile range [IQR] 7.8–14.8, and median age at tumor diagnosis of 4.9 years, IQR 2.5–6.9). Median time since active treatment for their PFBT was 5.2 years (IQR 2.4–10.1). Tumor types included cerebellar pilocytic astrocytoma (45.2%), medulloblastoma (30.6%), ependymoma (11.3%), and brainstem astrocytoma (11.3%). Adjuvant therapy included chemotherapy (40.3%) or radiotherapy (14.5% focal and 21.0% craniospinal radiotherapy). Permanent treatment for hydrocephalus was required in 38.7% of the patients. Tumors recurred in 11.3%, requiring repeat treatment in these patients. The median HUI3 utility score was 0.91 (IQR 0.71–1.00) and the median PedsQL total score was 78.3 (IQR 64.1–92.4). Only the following variables were significantly associated with decreased QOL in multivariable model testing (all p < 0.05): need for permanent hydrocephalus treatment, large ventricle size, decreased family functioning, and lower family income. Conclusions As a group, long-term survivors of pediatric PFBT appear to have QOL indicators that are similar to those of the general population, although a reasonable minority of patients experience poor outcomes. Although several confounding variables likely remain in this retrospective study, important associations with QOL include the presence of hydrocephalus and socioeconomic factors. The study sample size, however, was limited and the presence of other important factors cannot be excluded.

show abstract

Morphometric evaluation of the hydrocephalic brain: relationships with cognitive development

Cited by 62 publications

References 13 publications

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

Study of corpus callosum in experimental hydrocephalic wistar rats

Long-term quality of life in children treated for posterior fossa brain tumors

Contact Info

Product

Resources

About