Morphometric Evaluation of Fine Needle Biopsy of Single Thyroid Nodules

Sassi, Isabella; Mangili, Federica; Sironi, Maria; Freschi, Massimo; Cantaboni, A

doi:10.1016/s0344-0338(89)80226-2

Cited by 11 publications

(13 citation statements)

References 4 publications

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“…In general, virtually all studies have found statistically significant differences in nuclear area (and many other nuclear features evaluated) between benign and PTC nuclei (Table ) . Many have reported sufficient overlap to limit the utility in clinical practice, but others have found that nuclear area, alone or in combination with other morphometric features, can achieve accuracy of 70% or greater . The current study found relatively good distinction by nuclear area, albeit with limited overlap in cases with indefinite qualitative cytologic interpretations.…”

Section: Discussionsupporting

confidence: 46%

“…However, nearly all studies have used nuclear area as one of their indicators, and several have used some sort of measure of roundness/ovalness. In general, virtually all studies have found statistically significant differences in nuclear area (and many other nuclear features evaluated) between benign and PTC nuclei (Table ) . Many have reported sufficient overlap to limit the utility in clinical practice, but others have found that nuclear area, alone or in combination with other morphometric features, can achieve accuracy of 70% or greater .…”

Section: Discussionmentioning

confidence: 99%

“…Yashaswini et al looked at a series of cases that had been misdiagnosed on initial cytology and found that the morphometric parameters including nuclear area were more similar to the eventual histologic diagnosis than to the initial incorrect cytologic diagnosis. Similarly, Sassi et al evaluated 14 suspicious FNA smears (using pre‐Bethesda terminology) and found nuclear area statistically significant, but standard deviation of nuclear area most valuable, with 77% accuracy.…”

Section: Discussionmentioning

confidence: 99%

“…[29][30][31][32][33][34][35][36][37][38][39][40][41][42] Many have reported sufficient overlap to limit the utility in clinical practice, but others have found that nuclear area, alone or in combination with other morphometric features, can achieve accuracy of 70% or greater. 31,32,34,35,41,42 The current study found relatively good distinction by nuclear area, albeit with limited overlap in cases with indefinite qualitative cytologic interpretations. Taken together, the current study and past literature support the utility of nuclear morphometry, especially nuclear area, as a useful tool to help with cytologic classification, but probably not as a stand-alone test, to distinguish PTC from benign on smears.…”

Section: Cancer Cytopathology August 2019mentioning

confidence: 99%

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Digital image‐assisted quantitative nuclear analysis improves diagnostic accuracy of thyroid fine‐needle aspiration cytology

Chain

Legesse

Heath

et al. 2019

Cancer Cytopathology

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Background Thyroid fine‐needle aspiration (FNA) plays a key role in triaging thyroid nodules. Yet many cases are assigned to indeterminate categories. The new category “noninvasive follicular thyroid neoplasm with papillary‐like features” (NIFTP) complicates thyroid cytology. Digital image‐derived nuclear measurements might objectively distinguish papillary thyroid carcinoma (PTC) from benign nodules and NIFTP. Methods All thyroid FNAs from 2012 to 2016 of atypia of undetermined significance (A; n = 8) and suspicious for malignancy (S; n = 2) with sufficient cellularity and surgical follow‐up, all FNAs preceding NIFTP (n = 6), and a random sample of PTC (n = 9) and benign (n = 10) cytology were studied. A modified Giemsa‐stained slide from each case was scanned using the Aperio imaging system, and long (dl) and short (ds)‐axis diameters were measured for 125 nuclei per case. Nuclear area and elongation were calculated. Results Nuclear area was larger in PTC (mean, 77.2 μm2 [range, 70.6‐86.0 μm2]) than benign (mean, 43.3 μm2 [range 38.2‐52.2 μm2]) (P < .001). Nuclear areas from indeterminate FNAs segregated according to final histology (A/S PTC mean 72.7 μm2, A/S benign mean 53.7 μm2; P = 0.004), and were not significantly different from definitive FNAs of the same diagnosis. NIFTP nuclear area was smaller than PTC (mean, 54.8 μm2 [range, 46.7‐66.1 μm2]; P < .001). Nuclear elongation showed similar results, but with greater group overlap. Conclusion Nuclear area and elongation can be calculated using a commercial digital imager; both correlate with the final surgical pathology diagnosis of PTC versus benign, including NIFTP. Area provides greater resolution than elongation. This technique could be used to resolve indeterminate cytology in which PTC is considered.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cancer Cytopathology August 2019mentioning

confidence: 99%

See 2 more Smart Citations

Digital image‐assisted quantitative nuclear analysis improves diagnostic accuracy of thyroid fine‐needle aspiration cytology

Chain

Legesse

Heath

et al. 2019

Cancer Cytopathology

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“…It has been already found in a previous study that the degree of anisokaryosis can be a useful feature in differentiating malignant neoplastic lesions from both neoplastic and specific non‐neoplastic benign lesions 8 . It has been shown that the degree of anisokaryosis in all the benign lesions examined (which did not include NRG) was lower than in malignant neoplasms, concordant with the observations by Sassi et al ., 16 Solymosi et al 17 . and Nagashima et al 18 .…”

Section: Discussionsupporting

confidence: 88%

Fine needle aspiration cytology in non‐neoplastic non‐toxic recurrent nodular goitre

Słowińska-Klencka¹,

Klencki²,

Sporny

et al. 2003

Cytopathology

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The aim of the study was to examine whether evaluation of anisokaryosis is helpful in the cytological diagnosis of focal lesions in non-toxic recurrent goitre (NRG) after thyroidectomy for non-malignant goitre. Karyometric analysis was performed in routine cytological smears obtained from 80 females: 40 with focal lesions in non-toxic primary goitre (NPG) and 40 with NRG (postoperative histopathological examination revealed nodular goitre in both groups in all cases). We found that the level of anisokaryosis was significantly (P<0.005) higher in NRG than in NPG. There were no significant differences between the two lesions, in cellular composition or thyroid follicular cell arrangement. Thus, isolated anisokaryosis, a feature of malignancy in patients without a prior thyroidectomy, has limited diagnostic value in recurrent goitre.

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Usefulness of computer-aided karyometric examination in preoperative differentiation of Hürthle cell lesions

Słowińska-Klencka¹,

Klencki²,

Sporny³

et al. 1997

Diagn. Cytopathol.

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Morphometric Evaluation of Fine Needle Biopsy of Single Thyroid Nodules

Cited by 11 publications

References 4 publications

Digital image‐assisted quantitative nuclear analysis improves diagnostic accuracy of thyroid fine‐needle aspiration cytology

Digital image‐assisted quantitative nuclear analysis improves diagnostic accuracy of thyroid fine‐needle aspiration cytology

Fine needle aspiration cytology in non‐neoplastic non‐toxic recurrent nodular goitre

Usefulness of computer-aided karyometric examination in preoperative differentiation of Hürthle cell lesions

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