Morphometric development of the tongue in fetal cadavers

Dursun, Ahmet; Kastamonı, Yadigar; Kacaroglu, Demet; Yüzbaşioğlu, Neslihan; Ertekın, Tolga

doi:10.1007/s00276-019-02301-z

Cited by 6 publications

(11 citation statements)

References 22 publications

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“…Макроанатомический метод в публикациях последних лет применяется ограниченно, в комплексе с морфометрией, что может быть обусловлено ограничением получения материалов для исследования [2,22,23]. За исследуемый период изучение внешнего строения языка у плодов человека проводилось зарубежными авторами и затрагивало 10-40 недели эмбрионального развития [1,24].…”

Section: результаты и их обсуждениеunclassified

“…Морфометрические данные о линейных параметрах языка человека в пренатальном периоде развития ограниченны и представлены в основном зарубежными данными [2,5,24]. Согласно исследованию, проведенному A. отечественными авторами на сегодняшний день является изучение и характеристика гистотопограмм [1,[24][25][26].…”

Section: результаты и их обсуждениеunclassified

“…Я зык представляет собой мышечный сложный орган, участвующий в формировании речи, а также жевании, глотании, дыхании, контроле секреции, сосании и ощущении вкуса [1,2,3]. Эмбриональное развитие языка начинается на 4-5 неделе внутриутробного периода, оказывая существенное влияние на формирование полости рта, а также костей лицевого черепа, что отмечено у отечественных и зарубежных авторов и определяет актуальность изучения данного вопроса [4,5,6].…”

Section: Introductionunclassified

“…Клиническое значение изучения особенностей эмбрионального развития языка человека обусловлено тем, что нарушение процессов эмбрионального развития языка, проявляющееся изменением формы, строения и размеров, является составляющим более чем 25 различных пороков развития, в частности синдромов Дауна, Робинова, Фримена -Шелдона и других [7][8][9]. При этом макроглоссия является одной из самых частых причин нарушений детской речи [2].…”

Section: Introductionunclassified

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Current data on the development of tongue in prenatal period of human ontogenesis

Alekseeva

Луцай

2022

Science and Innovations in Medicine

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The timely diagnosis and treatment of maxillofacial pathologies where the tongue plays an important role requires an accurate description of the organs structure and development. The paper presents a review of the current research data on the features of embryonic development, macro- and microanatomy, morphometry and ultrasound anatomy of the human tongue during the prenatal development. The selected papers, published in the Russian and English languages, cover the period of the last decade. We generalized the obtained data using the empirical and theoretical approaches. The macroscopic study of the external structure of the tongue was underrepresented in the current studies, usually performed in combination with morphometry. The studies of histotopograms in combination with histochemical methods were numerous, contributing to the more detailed classification of the tongue development stages. The selected papers focused on the period of human embryonic development and the correlating histological characteristics of the tongue. The morphometric characteristics and the blood supply of the tongue in the prenatal period require further research.

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Section: результаты и их обсуждениеunclassified

Section: Introductionunclassified

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Current data on the development of tongue in prenatal period of human ontogenesis

Alekseeva

Луцай

2022

Science and Innovations in Medicine

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“…Throughout pregnancy, the tongue continuously increases in size. [3][4][5][6][7] Abnormal fetal tongue size is a phenotypic feature of various significant congenital syndromes and conditions including Down syndrome, Beckwith-Wiedemann Syndrome, Pierre-Robin Sequence, Simpson-Golabi, Oromandibular Limb Hypoplasia, mucopolysaccharidoses, chromosomal abnormalities, and more. 1,3,5,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Tongue anomalies may present as an isolated finding 9,10,15 and, occasionally, it may be the only presenting prenatal feature of a genetic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Fetal Micro and Macroglossia

Koren

Shust-Barequet

Weissbach

et al. 2022

J of Ultrasound Medicine

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Objectives Abnormal fetal tongue size is a phenotypic feature of various syndromes including Beckwith‐Wiedemann, Pierre‐Robin, oromandibular limb hypoplasia, chromosomal aberrations, etc. Current data regarding normal fetal tongue size are limited. Hence, micro/macroglossia are subjectively determined. The aim of the study was to construct a contemporary fetal tongue nomogram and to assess its clinical contribution. Methods A prospective cross‐sectional study was performed in well dated, low risk, singleton pregnancies. Fetal tongues were measured by 5 trained sonographers. Highest quality images were selected. Intra‐ and interobserver variability was assessed. Tongue length, width, area, and circumference 1st to 99th centiles were calculated for each gestational week. Based on the normal tongue size charts, we created a Tongue Centile Calculator. Results Over 18 months, 664 tongue measurements were performed. A cubic polynomial regression model best described the correlation between tongue size and gestational age. The correlation coefficient (r2) was 0.934, 0.932, 0.925, and 0.953 for tongue length, width, area, and circumference, respectively (P < .001). Intra‐ and interobserver variability had high interclass correlation coefficients (>0.9). Using the new charts, we were able to identify 2 cases of macroglossia, subsequently diagnosed with Beckwith‐Wiedemann, and 4 cases of microglossia, 3 associated with Pierre‐Robin sequence, and 1 associated with persistent buccopharyngeal membrane. Conclusions We present novel fetal tongue size charts from 13 to 40 weeks of gestation. Clinical application of these nomograms may be beneficial in the prenatal diagnosis of syndromes or malformations associated with abnormal fetal tongue size.

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