Morphometric comparison of the human corpus callosum in deaf and hearing subjects: an MRI study

Kara, Ali Yücel; Öztürk, Ahmet Hakan; Kurtoğlu, Zeliha; Talaş, Derya Ümit; Aktekın, Mustafa; Saygılı, Muaffak Refik; Kanık, Arzu

doi:10.1016/s0150-9861(06)77253-4

Cited by 11 publications

(11 citation statements)

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“…Two-sample t tests were conducted to reveal where deaf individuals exhibited greater GMV or WMV than hearing individuals and vice versa. Images were thresholded at a height level of p Ͻ 0.005 (minimum cluster size ϭ 95 contiguous voxels) and nonstationary cluster corrected (Hayasaka et al, 2004) at a threshold of p Ͻ 0.05. There were no between-group differences in total intracranial volume (TIV: the sum of whole-brain GMV, WMV, and CSF), but to be sure to infer regional variation in brain matter, this measure was included as a regressor of no interest in the analyses (Peelle et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, observation of more GMV could reflect normal maturation, but also failure to mature, depending on the location. In sum, the mechanisms underlying microstructural changes and their interpretation require further study and will benefit from other measures, such as gyrification patterns (Im et al, 2010). Whether classical language areas in the left superior temporal lobe, also closely located to auditory cortex, are used differently in the deaf has been a topic of debate, especially in the context of sign language processing.…”

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Neuroanatomical Profiles of Deafness in the Context of Native Language Experience

et al. 2014

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The study of congenitally deaf adult humans provides an opportunity to examine neuroanatomical plasticity resulting from altered sensory experience. However, attributing the source of the brain's structural variance in the deaf is complicated by the fact that deaf individuals also differ in their language experiences (e.g., sign vs spoken), which likely influence brain anatomy independently. Although the majority of deaf individuals in the United States are born to hearing parents and are exposed to English, not American Sign Language (ASL) as their first language, most studies on deafness have been conducted with deaf native users of ASL (deaf signers). This raises the question of whether observations made in deaf signers can be generalized. Using a factorial design, we compared gray (GMV) and white (WMV) matter volume in deaf and hearing native users of ASL, as well as deaf and hearing native users of English. Main effects analysis of sensory experience revealed less GMV in the deaf groups combined (compared with hearing groups combined) in early visual areas and less WMV in a left early auditory region. The interaction of sensory experience and language experience revealed that deaf native users of English had fewer areas of anatomical differences than did deaf native users of ASL (each compared with their hearing counterparts). For deaf users of ASL specifically, WMV differences resided in language areas such as the left superior temporal and inferior frontal regions. Our results demonstrate that cortical plasticity resulting from deafness depends on language experience and that findings from native signers cannot be generalized.

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Section: Methodsmentioning

confidence: 99%

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Neuroanatomical Profiles of Deafness in the Context of Native Language Experience

et al. 2014

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“…Este se afila para formar o rostro do CC, porção contígua à comissura anterior. Alterações de espessura e volume do CC, em estudos com ressonância magnética de adultos, descrevem as mais variadas correlações com patologias psiquiátricas e neurológicas, tais como: déficit de atenção, hiperatividade, distúrbio bipolar, esquizofrenia e alterações da audição [17][18][19] .…”

Section: Discussionunclassified

Avaliação do comprimento e área do corpo caloso fetal por meio da ultrassonografia tridimensional

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Rôlo

et al. 2010

Rev. Bras. Ginecol. Obstet.

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Artigo originalResumo OBJETIVO: determinar os valores de referência para o comprimento e a área do corpo caloso fetal entre a 20 a e 33 a semanas de gestação por meio da ultrassonografia tridimensional (US3D). MÉTODOS: foi realizado um estudo do tipo corte transversal com 70 gestantes normais entre a 20 a e 33 a semanas de gestação. Utilizou-se um aparelho da marca Accuvix XQ, equipado com transdutor convexo volumétrico (3 a 5 MHz). Para a obtenção do corpo caloso fetal, foi utilizado um plano transfrontal, com a sutura metópica como janela acústica. Para o cálculo do comprimento, utilizou-se a distância entre os pontos médios dos polos proximal e distal do corpo caloso. Para o cálculo da área, a delimitação manual da superfície externa do corpo caloso foi realizada. Para o comprimento e a área do corpo caloso, foram calculadas: as médias, as medianas, os desvios padrão e os valores máximo e mínimo. Para a correlação da área e do comprimento do corpo caloso com a idade gestacional e o diâmetro biparietal foram criados diagramas de dispersão, sendo a qualidade dos ajustes verificada pelo coeficiente de determinação (R 2 ). Para a variabilidade intraobservador, utilizou-se o coeficiente de correlação intraclasse (CCI). RESULTADOS: a média do comprimento do corpo caloso variou de 21,7 mm (18,6 -25,2 mm) a 38,7 mm (32,6 -43,3 mm) entre a 20 a e 33 a semanas, respectivamente. A média da área do corpo caloso variou de 55,2 mm 2 (41,0 -80,0 mm 2 ) a 142,2 mm 2 (114,0 -160,0 mm 2 ) entre a 20 a e 33 a semanas, respectivamente. O comprimento e a área do corpo caloso foram fortemente correlacionados com a idade gestacional (R 2 = 0,7 e 0,7, respectivamente) e com o diâmetro biparietal (R 2 = 0,7 e 0,6, respectivamente). A variabilidade intraobservador foi adequada com CCI = 0,9 e 0,9 para o comprimento e área, respectivamente. CONCLUSÕES: valores de referência para o comprimento e área do corpo caloso fetal entre a 20 a e 33 a semanas foram determinados. A variabilidade intraobservador foi adequada.Abstract PURPOSE: to establish reference values for the length and area of the fetal corpus callosum between the 20 th and 33 rd weeks of gestation using three-dimensional ultrasound (3DUS). METHODS: this cross-sectional study involved 70 normal pregnancies with gestational age between 20 and 33 weeks. An Accuvix XQ instrument with a convex volumetric transducer (3 to 5 MHz) was used. To assess the corpus callosum, a transfrontal plane was obtained using the metopic suture as an acoustic window. Length was obtained by measuring the distance between the proximal and distal extremities of the corpus callosum. Area was obtained by manual tracing of the external corpus callosum surface. The means, medians, standard deviations, and maximum and minimum values were calculated for the corpus callosum length and area. Scatter graphs were created to analyze the correlation between corpus callosum length and area and gestational age and biparietal diameter, the quality adjustments was verified according to the determination coefficient (R...

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“…Third, there is also a wide variation in the age in these groups and only one study focused on babies who were being evaluated for cochlear implants (K. M. Smith et al, 2011). Fourth, while morphometry analysis focused on mostly volumes of gray matter and white matter structures, nine measured cortical thickness (Hribar et al, 2014;Kumar & Mishra, 2018;Pereira-Jorge et al, 2018;Ratnanather et al, 2019;Shiell et al, 2016;Shiohama et al, 2019;Smittenaar et al, 2016) and one measured surface area (Kara et al, 2006). Fifth, weak differences were observed in several structures.…”

Section: The Deafened Auditory Pathwaymentioning

confidence: 99%

Structural neuroimaging of the altered brain stemming from pediatric and adolescent hearing loss—Scientific and clinical challenges

Ratnanather

2019

WIREs Mechanisms of Disease

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There has been a spurt in structural neuroimaging studies of the effect of hearing loss on the brain. Specifically, magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) technologies provide an opportunity to quantify changes in gray and white matter structures at the macroscopic scale. To date, there have been 32 MRI and 23 DTI studies that have analyzed structural differences accruing from pre-or peri-lingual pediatric hearing loss with congenital or early onset etiology and postlingual hearing loss in pre-to-late adolescence. Additionally, there have been 15 prospective clinical structural neuroimaging studies of children and adolescents being evaluated for cochlear implants. The results of the 70 studies are summarized in two figures and three tables. Plastic changes in the brain are seen to be multifocal rather than diffuse, that is, differences are consistent across regions implicated in the hearing, speech and language networks regardless of modes of communication and amplification. Structures in that play an important role in cognition are affected to a lesser extent. A limitation of these studies is the emphasis on volumetric measures and on homogeneous groups of subjects with hearing loss.It is suggested that additional measures of morphometry and connectivity could contribute to a greater understanding of the effect of hearing loss on the brain. Then an interpretation of the observed macroscopic structural differences is given. This is followed by discussion of how structural imaging can be combined with functional imaging to provide biomarkers for longitudinal tracking of amplification.

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Morphometric comparison of the human corpus callosum in deaf and hearing subjects: an MRI study

Cited by 11 publications

References 18 publications

Neuroanatomical Profiles of Deafness in the Context of Native Language Experience

Neuroanatomical Profiles of Deafness in the Context of Native Language Experience

Avaliação do comprimento e área do corpo caloso fetal por meio da ultrassonografia tridimensional

Structural neuroimaging of the altered brain stemming from pediatric and adolescent hearing loss—Scientific and clinical challenges

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