Morphometric analysis of intimal thickening secondary to stent placement in pig carotid arteries

Pasa, Márcio Bastiani; Pereira, Adamastor Humberto; Jùnior, Cyro Castro

doi:10.1590/s0102-86502008000200009

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…The hyperplasia secondary to angioplasty and cobalt-chromium stent placement does not appear to differ from that found after placement of devices made from 316L-grade stainless steel or nitinol in previous studies conducted in our experimental unit. Various studies conducted by Pasa et al, Grudtner et al, Dutra et al e Castro et al [21][22][23][24] have shown the role of angioplasty-and stent-induced vascular injury, regardless of alloy and coating, in the intimal hyperplasia process.…”

Section: Discussionmentioning

confidence: 99%

“…Past studies have reported development of full-blown intimal hyperplasia, similar to that found in humans, within 28 days. [12][13][14]20 In prior studies, Pasa et al 21 conducted morphometric analysis of intimal thickening in the swine carotid artery after placement of 316L-grade stainless steel stents, without angioplasty, and concluded that intimal thickening induced by the stent is greater than that produced by injury of the contralateral artery by the introducer sheath. The mere presence of a stent, even in the absence of rupture of the internal elastic lamina, is therefore enough to produce intimal hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

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Análise morfométrica da carótida de suínos submetidos a angioplastia com ou sem implante de stent de cromo-cobalto

Elesbão

Pereira

Grudtner³

et al. 2010

J. vasc. bras.

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Contexto: A hiperplasia intimal é a reação tardia mais comum decorrente da angioplastia. O uso de stents de cromo-cobalto é bem estudado na circulação coronariana, porém não há muitos estudos que abordem o uso desses stents nas circulações carotídea e periférica. Objetivo: Analisar mediante morfometria a reação intimal presente na artéria carótida de suínos submetidos a angioplastia isoladamente e a angioplastia seguida de implante de stent de cromo-cobalto. Materiais e métodos: Em oito suínos, foi realizada angioplastia da artéria carótida comum direita e angioplastia seguida de implante de um stent de cromo-cobalto na artéria carótida comum esquerda. Após 4 semanas, os animais foram submetidos a eutanásia para a retirada de amostras de tecido arterial e preparo de lâminas histológicas. As imagens das lâminas foram digitalizadas e analisadas por programa de morfometria digital. A análise estatística foi realizada através da média e desvio padrão das áreas em cada grupo, utilizando-se o Teste t de Student. O valor de p < 0,05 foi considerado significativo. Resultados: O implante do stent provocou maior grau de hiperplasia comparado à angioplastia isolada. A diferença em resposta ao implante de stent foi estatisticamente significativa quando as áreas do lúmen, da lâmina elástica interna e da lâmina elástica externa foram comparadas entre os dois grupos. Não se observou diferença significativa quando se realizou a comparação entre as camadas médias dos dois grupos. Conclusão: O implante de stent de cromo-cobalto gerou um espessamento intimal maior do que o produzido apenas pela angioplastia, porém ele não foi suficiente para reduzir o lúmen arterial.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Análise morfométrica da carótida de suínos submetidos a angioplastia com ou sem implante de stent de cromo-cobalto

Elesbão

Pereira

Grudtner³

et al. 2010

J. vasc. bras.

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“…As mentioned, some animals are used as experimental model to evaluate vascular hyperplasia. Swine are often selected as a model for monitoring the lesion, due to the similarity with human in the response to vascular injury, so morphometric studies are carried out for controlled evaluation of chronic arterial injury [44]. Similarly, rodent models are also found to be useful because they are animals with short life cycle, available for genetic manipulation, presenting relative low cost laboratory maintenance, and mainly because of the similarity with humans in the spontaneous development of atherosclerosis during their lifetime [39].…”

Section: Fig 3 Proportion Of the Lumen Of Coronary Arteries In Relation To The Months Of Cultivation With Simulated Envelope For Residuesmentioning

confidence: 99%

Morphometry in Coronary Arteries of Beijupira (Rachycentron canadum) Fish with Tunics Hyperplasia

Pedrosa

Romano

Manghi

et al. 2021

AJRiZ

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Tunics hyperplasia of blood vessels can be quantified by a range of techniques that relate to modifications of area or thickness on histological sections. We studied hyperplasia of tunics of coronary arteries in a fish species, Rachycentron canadum for establishing the relationship between tunics and luminal obstruction by morphometry. The morphometric analysis was performed on 158 arterial vessels of 40 fish samples. The histological slides of cardiac and vascular tissue were stained using hematoxylin and eosin and observed under an optical microscope. The data relating to the proportion of the lumen area compared to the area of the tunic media were analyzed according to Beta regression models. The lumen proportion showed a decreasing relationship with weight and length of the analyzed animals. A linear relationship was not observed between lumen proportion and areas and/or radius of arterial tunics. It is concluded that the increase in weight gain contributes to a reduction of lumen area, leading to arterial obstruction without increasing or decreasing relationship between the proportion of vascular lumen and the thickness of arterial tunics. The set of abnormalities described are likely to be attributed to nutritional factors during the fish cultivation.

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Prevention of Lesion Recurrence in Endovascular Devices

Rochier

Sumpio

2009

Peripheral Endovascular Interventions

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Morphometric analysis of intimal thickening secondary to stent placement in pig carotid arteries

Abstract: All arteries that underwent stent placement showed intimal thickening without changes in the tunica media at four weeks. Dissection and insertion of the delivery system without stent placement was associated with a lesser degree of intimal thickening.

Cited by 3 publications

References 20 publications

Análise morfométrica da carótida de suínos submetidos a angioplastia com ou sem implante de stent de cromo-cobalto

Análise morfométrica da carótida de suínos submetidos a angioplastia com ou sem implante de stent de cromo-cobalto

Morphometry in Coronary Arteries of Beijupira (Rachycentron canadum) Fish with Tunics Hyperplasia

Prevention of Lesion Recurrence in Endovascular Devices

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