Morphology of the Thyroid Gland in Jamaica

Harland, W. A.

doi:10.1210/jcem-24-7-580

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…In a healthy population resident in tropical Jamaica, TSR, as measured by the method of Riggs (1952), was found to average 14,tg hormonal iodine/day, while the PBI was 5-3 ptg/100 ml. (Harland, 1964). The PBI is identical with that found in temperate zones but the TSR is very much lower than the temperate zone value of 53 ,ug/day (Ingbar & Freinkel, 1955).…”

Section: Thyroxine Metabolismsupporting

confidence: 74%

A model of thyroxine metabolism based on the effects on environmental temperature

Harland¹,

Orr²

1969

The Journal of Physiology

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3. It is demonstrated that, in the rabbit, free labelled thyroxine and plasma bound labelled thyroxine leave the plasma at different rates when administered by intravenous injection.4. It is deduced from the above and other evidence that the currently accepted view of thyroxine distribution and metabolism is invalid and a model compatible with the evidence is presented and discussed.5. The essential feature of the model is that protein binding in plasma or in various tissues, once it has occurred, may be regarded as being irreversible and that no significant interchange takes place.6. Indices of thyroxine metabolism are derived. These enable thyroxine content and turnover of the whole body or of individual organs to be measured.

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Section: Thyroxine Metabolismsupporting

confidence: 74%

A model of thyroxine metabolism based on the effects on environmental temperature

Harland¹,

Orr²

1969

The Journal of Physiology

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“…These two discrepancies will tend to balance out and it must be concluded that the Jamaican population investigated had a relatively low iodine intake. However, there is no evidence of endemic goitre in Jamaica (Harland, 1964).…”

Section: Resultsmentioning

confidence: 99%

Reduced Thyroid Activity in Jamaicans

Harland¹,

Richards²,

Goldberg³

1971

Journal of Endocrinology

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The results presented demonstrate reduced thyroid activity in euthyroid Jamaicans. In 15 subjects, thyroid clearance of 131I was 13\m=.\0\ m=+-\ 8\m=. \8(s.d.) ml/min, and renal clearance was 20\m=.\6\ m=+-\9\m=.\7 ml/min. In 205 healthy volunteers the 24 h 131I thyroid uptake averaged 13\m=.\8 % and in 60\m=.\9% the uptake was less than 10 % of the dose. Urinary excretion of 131I was correspondingly high. However, excretion of stable iodine in urine averaged only 62\ m=. \ 0\ g=m\ g/ day. Thyroid secretion rate (TSR) calculated in a group of subjects with complete collection of urine was 12\m=.\0\ g=m\gI/day in women and 11\m=.\4\g=m\gI/day in men. Protein-bound iodine (PBI) values in 50 subjects were 5\ m=. \ 9\ m=+-\ 1\ m=. \ 3\ g=m\ g/ 100 ml. Uptake of tri-iodothyronine by red blood cells also gave low values. The apparent discrepancy between low TSR and normal PBI is discussed. These findings, together with other reported values, indicate reduced thyroid activity in the tropics. It is argued that reduced metabolism is probably secondary to lower thyroid activity.

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“…This reduction is probably due to a generalized reduction in body size. It is evidence that severe cold stress is accompanied by increased thyroidal activity and hypometabolic state develops in tropical residents 1 . …”

Section: Introductionmentioning

confidence: 99%

Weight and Volume of Whole Thyroid Gland In Bangladeshi People: A Postmortem Study

et al. 1970

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Methods: The collected specimens were divided into age group A (20 years and below), group B (21 to 50 years) and group C (above 50 years). All specimens were examined morphologically by fine dissection method. Result:The mean weight and volume of the thyroid gland was 13.27 ± 5.82 gm and 11.62 ± 4.76 ml respectively which are significant (p<0.01). Conclusion: From observation and results it reached conclusion that evidenced by weight and volume

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Morphology of the Thyroid Gland in Jamaica

Cited by 7 publications

References 1 publication

A model of thyroxine metabolism based on the effects on environmental temperature

A model of thyroxine metabolism based on the effects on environmental temperature

Reduced Thyroid Activity in Jamaicans

Weight and Volume of Whole Thyroid Gland In Bangladeshi People: A Postmortem Study

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