Morphology of the pineal gland of forest mice with the delay of sexual ripening

Герасимов, А. В.; Логвинов, С. В.; Костюченко, В. П.; Kravchenko, L. B.

doi:10.20538/1682-0363-2012-4-22-25

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Information on the effect of ethanol on changes in the morphometric parameters of pinealocytes in the literature we have studied is limited [15]. However, our studies correlate with data from other researchers who studied changes in the morphology of the pineal gland in response to the influence of pathological factors of endogenous and exogenous origin [4,6,9,13].…”

Section: Discussionsupporting

confidence: 76%

Morphometric features of rat pinealocytes in conditions of chronic ethanol intoxication

Pshychenko

Черно

2021

Rep. of Morph.

View full text Add to dashboard Cite

Ethanol has chronobiological effects, which are associated with inhibition of melatonin synthesis and secretion and disruption of the sleep-wake cycle. Ethanol is known to cause sleep fragmentation due to frequent awakenings, prolong wakefulness, and reduce the duration of the slow sleep phase. At the same time, changes in the morphology of the pineal gland under chronic exposure to ethanol remain poorly studied. Of particular interest are changes in the basic morphometric parameters of pinealocytes, because they are a marker of the functional state of the pineal gland. The aim of the study was to morphometrically study the features of morphological changes in rat pinealocytes in the physiological norm and in chronic ethanol intoxication. To achieve this goal, we used 20 laboratory male rats: a control group and an experimental group. The control group was under standard vivarium conditions. For the experimental group, alcohol intoxication was modeled by injecting a 40% ethanol solution at the rate of 12 mg/kg of body weight intragastric 4 times a day. The morphometric parameters of pinealocytes were studied on day 30 from the start of the study. According to the results of morphometric measurements, a significant increase in the parameters of light pinealocytes and a decrease in the parameters of dark cells were established. It was determined that the average values of the cytoplasm area of light pinealocytes increase by 54.55% (p<0.05), the area of the nucleus increases by 61.32% (p<0.05), and the area of the nucleolus by 32.84% (p<0.05) compared with the control group. The area of the cytoplasm of dark pinealocytes decreases by 27.2% (p<0.05), and the area of the nucleus by 37.33% (p<0.05). Changes in the ratio of light and dark pinealocytes were also noted. An increase in the number of active light cells by 8.17% was found. The detected morphometric changes indicate high functional activity of cells, which has a compensatory nature in response to apoptosis of pinealocytes.

show abstract

Section: Discussionsupporting

confidence: 76%

Morphometric features of rat pinealocytes in conditions of chronic ethanol intoxication

Pshychenko

Черно

2021

Rep. of Morph.

View full text Add to dashboard Cite

show abstract

Pineal gland as an endocrine gravitational lunasensor: Manifestation of moon-phase dependent morphological changes in mice

Герасимов

Kostyuchenko

Solovieva

et al. 2014

Biochemistry Moscow

Self Cite

View full text Add to dashboard Cite

We found that some morphological properties of the pineal gland and submandibular salivary gland of mice are significantly distinct at the new and full moon. We suppose that the differences are initiated by the displacements of the electron-dense concretions in the secretory vesicles of pinealocytes. This presumably occurs under the influence of the gravitational field, which periodically changes during different phases of the moon. It seems that the pinealocyte is both an endocrine and gravisensory cell. A periodic secretion of the pineal gland probably stimulates, in a lunaphasic mode, the neuroendocrine system that, in turn, periodically exerts influence on different organs of the body. The observed effect probably serves, within the lifelong clock of a brain, to control development and aging in time.

show abstract

Morphology of the pineal gland of forest mice with the delay of sexual ripening

Cited by 2 publications

References 2 publications

Morphometric features of rat pinealocytes in conditions of chronic ethanol intoxication

Morphometric features of rat pinealocytes in conditions of chronic ethanol intoxication

Pineal gland as an endocrine gravitational lunasensor: Manifestation of moon-phase dependent morphological changes in mice

Contact Info

Product

Resources

About