Morphology of the Intestinal Barrier in Different Physiological and Pathological Conditions

Khan, Jesmine; Islam, Mohammed Nasimul

doi:10.5772/50659

Cited by 13 publications

(12 citation statements)

References 41 publications

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“…Generally, the change of digestive enzyme activity may determine the digestive and absorptive capacity, which influences the growth and development of fish (Liu, Zhang, & Wang, ). Moreover, the activities of digestive enzymes also play an important role in maintaining the intestinal barrier function against bacterial invasion (Khan & Islam, ). Similar to our results, it was reported that the supplementation of tributyrin in the diet can facilitate the activation of digestive enzyme activity (lactase, sucrase, maltase, lipase and trypsin) in intrauterine growth‐restricted piglets (Dong et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…This may be possible due to the inclusion of butyrate in glycerides form allowing it to be transported further along the digestive tract of black sea bream where it can exert beneficial impact on the gut morphology. Butyrate is a principal energy source of the colonic epithelium which can modulate enterocyte differentiation, proliferation and restitution, as well as mucus secretion from goblet cells in the small intestine (Böcker et al, ; Khan & Islam, ). Moreover, under normal or pathological conditions, BG can stimulate the growth of endothelial cells in vascular development (Bedford & Gong, ).…”

Section: Discussionmentioning

confidence: 99%

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Effects of butyrate glycerides supplementation in high soybean meal diet on growth performance, intestinal morphology and antioxidative status of juvenile black sea bream, Acanthopagrus schlegelii

Volatiana

Sagada

et al. 2019

Aquacult Nutr

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This study aimed to investigate the effects of graded butyrate glyceride (BG) supplementation levels in high soybean meal diet on juvenile black sea bream. Three hundred and sixty fish were fed diets containing 199 g/kg fishmeal and 450 g/kg soybean meal, with increasing levels of BG at 0, 2, 4, 6, 8 or 16 g/kg for eight weeks. The growth performance of the fish increased with increasing dietary BG supplementation up to 6 g BG/kg, beyond which growth rate reduced significantly (p < .05). Dietary BG supplementation increased the intestinal protease activity, but had no significant (p > .05) effect on lipase and amylase activities. Fish fed the basal diet exhibited villus shortening with a decrease in the number of goblet cells and a reduction in absorptive and digestive epithelial surface, while fish fed ≥4 g BG/kg diets showed a well‐integrated gut, with large absorptive and digestive epithelial surface. Dietary BG supplementation also improved antioxidative capacity by increasing superoxide dismutase and glutathione peroxidase activities while decreasing malondialdehyde content. The inclusion of BG in high soybean meal diets can improve growth performance, maintain healthy gut morphology and enhance antioxidative capacity of black sea bream.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of butyrate glycerides supplementation in high soybean meal diet on growth performance, intestinal morphology and antioxidative status of juvenile black sea bream, Acanthopagrus schlegelii

Volatiana

Sagada

et al. 2019

Aquacult Nutr

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“…Besides major digestion and absorption functions, the intestinal mucosa act as a critical barrier to toxic and harmful substances, protecting an individual from different antigenic and inflammatory reactions (Khan & Islam, ). Haematoxylin and eosin staining can help identify normal tissue and pathological tissue.…”

Section: Discussionmentioning

confidence: 99%

Effects of chromium yeast, tributyrin and bile acid on growth performance, digestion and metabolism ofChanna argus

Hou

Yao

et al. 2018

Aquac Res

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A 60-day feeding trial was carried out to evaluate the effects of chromium yeast (CY), tributyrin (TB) and bile acid (BA) on the snakehead (Channa argus). The control (CT) group was fed the basal diet, and the experimental groups were fed 200 mg/kg CY (concentration: 1,000 mg/kg), 2.5 g/kg TB (purity: 45%) or 1 g/kg BA (purity: 30%) in addition to the basal diet. The addition of CY, TB and BA statistically increased the weight gain rate, and specific growth rate, whereas the feeding rate and feed conversion ratio were significantly reduced (p < 0.05). When compared with the CT group, TB elevated the serum glutathion peroxidase (GSH-Px) activity; and BA reduced low density lipoprotein cholesterol (LDL-C) contents significantly (p < 0.05). The three feed additives reduced intestinal malonaldehyde (MDA) levels dramatically. Tributyrin significantly enhanced intestinal trypsin and pepsin activities (p < 0.05). The activity of fructose-1,6-bisphosphatase and pyruvate carboxylase in the group fed CY was significantly lower than in the CT group. In conclusion, dietary inclusion of the three additives enhanced growth performance of C. argus. Dietary supplementation of CY affected protein, glucose and lipid metabolism. Diets with TB levels improved intestinal digestive enzyme activity and antioxidant capacity. The addition of BA improved glycolipid metabolism. K E Y W O R D Sbile acid, chromium yeast, growth performance, snakehead, tributyrin

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“…However, early weaning can lead to intestinal inflammation and decreased intestinal integrity, which compromises nutrient digestion and absorption until the adaptation to a solid diet (Lackeyram et al, 2010). Avoiding impaired intestinal integrity is crucial to prevent perturbation of brush-border enzyme activity, loss of protein synthesis, and reduced gene expression of mucosal DNA and RNA, which cause lower gene expression resulting in reduced nutrient absorption due to decreased villus height and increased crypt depth (Khan and Islam, 2012) caused by the lower production of digestive enzymes and lower contact area with the feed.…”

Section: Introductionmentioning

confidence: 99%

Feed additives can differentially modulate NF-κB (RelA/p65), IGF-1, GLUT2, and SGLT1 gene expression in porcine jejunal explants

Silveira¹,

Melo

Bortoluzzi

et al. 2018

R. Bras. Zootec.

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The intestinal gene expression of RelA/p65 (NF-κB), insulin growth factor 1 (IGF-1), glucose transporter 2 (GLUT2), and Na+/dependent glucose transporter 1 (SGLT1) were evaluated in response to benzoic acid, yeast culture, L-glutamine, and oregano essential oil, using an ex vivo model. Six piglets weighing approximately 20 kg each were sacrificed, and their jejunum was collected and segmented into five 2-cm explants. Each explant was immersed in cell culture medium according to one of the following treatments: control (without additive), 0.5% benzoic acid, 1% yeast culture, 1% L-glutamine, and 0.015% oregano oil. Gene expression was evaluated using RT-PCR. Yeast culture up-regulated the gene expression of RelA/p65, IGF-1, GLUT2, and SGLT1 in comparison with control. In addition, jejunal exposure to L-glutamine and oregano oil increased mRNA levels of GLUT2 compared with the control treatment. Exposure to oregano oil increased intestinal SGLT1 gene expression, while benzoic acid reduced SGLT1 expression compared with the control. Feed additives can differently modulate the gene expression of immune response, gut development, and glucose absorption in jejunal explants. These findings can contribute for a better understanding of the trophic action of these feed additives into the diets to optimize animal performance.

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Morphology of the Intestinal Barrier in Different Physiological and Pathological Conditions

Cited by 13 publications

References 41 publications

Effects of butyrate glycerides supplementation in high soybean meal diet on growth performance, intestinal morphology and antioxidative status of juvenile black sea bream, Acanthopagrus schlegelii

Effects of butyrate glycerides supplementation in high soybean meal diet on growth performance, intestinal morphology and antioxidative status of juvenile black sea bream, Acanthopagrus schlegelii

Effects of chromium yeast, tributyrin and bile acid on growth performance, digestion and metabolism ofChanna argus

Feed additives can differentially modulate NF-κB (RelA/p65), IGF-1, GLUT2, and SGLT1 gene expression in porcine jejunal explants

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