Morphology of the Golgi Apparatus in Streptozotocin-Diabetic Rat Liver

Sodium orthovanadate exerts influence on liver Golgi complexes from control and streptozotocin-diabetic rats

“…The lowest effect in the improvement of biochemical and morphological parameters of Golgi complexes was found after the application of bis(kojato)oxovanadium(IV) [6]. The most characteristic alterations of STZ-diabetic untreated liver Golgi complexes were rounded cisterns in dictyosomes and lack of these marginal dilatations, as well as the disappearance of secretory vesicles (uncoated and coated) and vacuoles [29,30]. In STZ-diabetic rats treated with BMOV, the straightening of cisterns and the appearance of coated and uncoated vesicles and secretory vacuoles were noted.…”

“…Although the physiological and biochemical influence of these vanadium complexes on the organism, organ or tissue level is very well known, their molecular mechanism and effect on intracellular organelle is poorly understood. Moreover, as was previously found in our laboratory [28,29], the rat liver Golgi complex is very sensitive subcellular organelle, useful for testing drugs with cytoprotective [30] or normalizing [3,[5][6][7]13,31] activities against experimental streptozotocin[STZ]-diabetes, so we have been using it for years as an indicator of the effectiveness of the tested drugs. Experiments with four organic vanadium(IV) complexes:bis(maltolato)oxovanadium [BMOV], bis(2,2 0 -bispyridine)oxovanadium[VO(bpy) 2 ], bis(oxalato)-oxovanadium, bis(kojato)oxovanadium[VO(ka) 2 ] were performed by our team.…”