Morphology of on-off direction-selective ganglion cells in the rabbit retina

Amthor, Franklin R.; Oyster, Clyde W.; Takahashi, Ellen S.

doi:10.1016/0006-8993(84)91167-3

Cited by 195 publications

(153 citation statements)

References 11 publications

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“…Using a fluorescent stain, Jensen and DeVoe (1983) visualized these cells in the turtle retina and Amthor, Oyster and Takahashi (1984), used horseradish peroxidase (HRP) in the rabbit. The overall morphology of these cells appear to bear many similarities.…”

Section: Critical Predictions Of the Modelmentioning

confidence: 99%

Computations in the vertebrate retina: gain enhancement, differentiation and motion discrimination

Koch

Poggio²,

Torre

1986

Trends in Neurosciences

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Abstract.An understanding of brain function will ultimately require an understanding of the elementary information processing operations performed by synapses, membranes and neurons. Such know ledge, in addition to its intrinsic interest, will be instrumental for a full comprehension of the algorithms and computational procedures used by the brain to solve visual and other perceptual problems. The vertebrate retina is a very attractive model system for approaching the question of the information processing role of biological mechanisms of nerve cells. The retina provides the visual input to the brain and its main interface with the outside world. Its anatomy and physiology are relatively well known. We also have a fairly good idea of some of the information processing operations ---the computations ---performed by the retina. It is as yet impossible to provide a complete circuit diagram of the retina. But it is now possible to identify a few simple computations that the retina performs and to relate them to specific biophysical mechanisms and circuit elements, on the basis of theoretical work, computer simulations and experimental data. In this paper we consider three operations carried out by most retinae: amplification, temporal differentiation and computation of the direction of motion of visual patterns.

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Section: Critical Predictions Of the Modelmentioning

confidence: 99%

Computations in the vertebrate retina: gain enhancement, differentiation and motion discrimination

Koch

Poggio²,

Torre

1986

Trends in Neurosciences

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“…OFF RGC dendrites, also monolaminated, colocalize with OFF bipolar axonal terminals in sublamina a (Famiglietti and Kolb, 1976;Nelson et al, 1978). ON-OFF RGCs respond to light onset and offset and have bilaminated dendrites arborizing in both sublaminas a and b of the IPL (Amthor et al, 1984). Early in postnatal development, the retina is populated with a preponderance of RGCs having bilaminated dendritic arbors (Maslim and Stone, 1988;Bodnarenko et al, 1999;Tian and Copenhagen, 2003;Diao et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor and TrkB Modulate Visual Experience-Dependent Refinement of Neuronal Pathways in Retina

et al. 2007

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Sensory experience refines neuronal structure and functionality. The visual system has proved to be a productive model system to study this plasticity. In the neonatal retina, the dendritic arbors of a large proportion of ganglion cells are diffuse in the inner plexiform layer. With maturation, many of these arbors become monolaminated. Visual deprivation suppresses this remodeling. Little is known of the molecular mechanisms controlling maturational and experience-dependent refinement. Here, we tested the hypothesis that brainderived neurotrophic factor (BDNF), which is known to regulate dendritic branching and synaptic function in the brain, modulates the developmental and visual experience-dependent refinement of retinal ganglion cells. We used a transgenic mouse line, in which a small number of ganglion cells were labeled with yellow fluorescence protein, to delineate their dendritic structure in vivo. We found that transgenic overexpression of BDNF accelerated the laminar refinement of ganglion cell dendrites, whereas decreased TrkB expression or retina-specific deletion of TrkB, the cognate receptor for BDNF, retarded it. BDNF-TrkB signaling regulated the maturational formation of new branches in ON but not the bilaminated ON-OFF ganglion cells. Furthermore, BDNF overexpression overrides the requirement for visual inputs to stimulate laminar refinement and dendritic branching of ganglion cells. These experiments reveal a previously unrecognized action of BDNF and TrkB in controlling cell-specific, experience-dependent remodeling of neuronal structures in the visual system.

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“…The ON and OFF dendritic fields were frequently, but not always, the same size and overlapped roughly, though not exactly. These are the diagnostic properties of ON/OFF DS ganglion cells as first reported by Amthor et al (1984).…”

Section: The Morphology Of α Ganglion Cells and On/off Ds Ganglion Cellsmentioning

confidence: 58%

“…The dendrites make many retroflexive branches. This is the classic appearance of an ON/OFF DS ganglion cell as described by Amthor et al (1984). The effect of nicotine on different ganglion cell types.…”

Section: Stratification Of the Iplmentioning

confidence: 85%

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Stratification of alpha ganglion cells and ON/OFF directionally selective ganglion cells in the rabbit retina

Zhang

Hoshi

et al. 2005

Vis Neurosci

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The correlation between cholinergic sensitivity and the level of stratification for ganglion cells was examined in the rabbit retina. As examples, we have used ON or OFF α ganglion cells and ON/OFF directionally selective (DS) ganglion cells. Nicotine, a cholinergic agonist, depolarized ON/OFF DS ganglion cells and greatly enhanced their firing rates but it had modest excitatory effects on ON or OFF α ganglion cells. As previously reported, we conclude that DS ganglion cells are the most sensitive to cholinergic drugs. Confocal imaging showed that ON/OFF DS ganglion cells ramify precisely at the level of the cholinergic amacrine cell dendrites, and co-fasciculate with the cholinergic matrix of starburst amacrine cells. However, neither ON or OFF α ganglion cells have more than a chance association with the cholinergic matrix. Z-axis reconstruction showed that OFF α ganglion cells stratify just below the cholinergic band in sublamina a while ON α ganglion cells stratify just below cholinergic b. The latter is at the same level as the terminals of calbindin bipolar cells. Thus, the calbindin bipolar cell appears to be a prime candidate to provide the bipolar cell input to ON α ganglion cells in the rabbit retina. We conclude that the precise level of stratification is correlated with the strength of cholinergic input. Alpha ganglion cells receive a weak cholinergic input and they are narrowly stratified just below the cholinergic bands.

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Morphology of on-off direction-selective ganglion cells in the rabbit retina

Cited by 195 publications

References 11 publications

Computations in the vertebrate retina: gain enhancement, differentiation and motion discrimination

Computations in the vertebrate retina: gain enhancement, differentiation and motion discrimination

Brain-Derived Neurotrophic Factor and TrkB Modulate Visual Experience-Dependent Refinement of Neuronal Pathways in Retina

Stratification of alpha ganglion cells and ON/OFF directionally selective ganglion cells in the rabbit retina

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