Morphology of Joint Cartilage and Subhondral Bone Plate After Modeling Osteoporosis

Yakovenchuk, N. N.; Dedukh, Ninel

doi:10.29254/2077-4214-2017-4-3-141-324-327

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Next to the reduced bone trabeculae mass, one detects the destructive changes, namely the matrix delamination with collagen fiber imaging, focus of destruction, reduced osteocyte density. Most osteocytes are located in the wide lacunae with irregular edges, signaling the osteocytary osteolysis [15]. The cortical thickness of hip and tibia reduces from periosteum to endosteum.…”

Section: Postmenopausal Osteoporosis Modeling By Ovariectomymentioning

confidence: 99%

Experimental Modeling of Osteoporosis in Animals

Dedukh

Yakovenchuk

Nikolchenko

2021

PJS

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Experimental studies on animals under conditions of osteopenia and osteoporosis modeling significantly expand the view of the mechanisms of primary and secondary osteoporosis development, help determining the effect of various factors affecting the bone tissue, evaluate the effect of medications, new biomaterials, etc. Osteoporosis is a multifactorial disease; its clinical manifestations depend on a complex interplay of environmental, lifestyle and genetic factors. The review of the literature analyzes the data on the use of animals to assess the features of osteoporosis course when modeling this pathology by surgical and non-surgical methods. The article features the models of osteoporosis which are reproduced on rats and mice being the most accessible objects and the most frequently used by experimenters. The details of modeling the course of such types of osteoporosis as postmenopausal, senile, glucocorticoid-induced, testosterone deficiency (orchiectomy)-induced, immobilization, hypothermia, radiation-induced, etc. are explored. A specific aspect of recent advances in modeling osteoporosis is the creation of transgenic and knockout mice, whose models may be used to detect components of genetic lesions and will certainly contribute to the development of new methods of prevention and therapy of this severe pathology. The similarity and difference of experimental models of osteoporosis describing the pathophysiological changes in humans due to osteoporosis are noted. Emphasis is placed on bioethical norms of working with experimental animals.

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