“…This does not necessarily militate against a direct viral mechanism, however, but CMV, in vitro at least, is known to produce predominantly "incomplete" or non-infective particles. 27 One might therefore postulate that the mechanism of hemolysis involves the attachment of such viral particles to erythrocytes, a process for which experimental models, e.g., influenza virus, exist. The particles, released into the circulation from sites of active infection in the RE system, would sensitize the cells to which they are attached, and which are then rapidly destroyed by RE cells or, in extreme cases, within the circulation.…”