Morphology impact on oxygen sensing ability of Ru(dpp)3Cl2 containing biocompatible polymers

Zhao, Susan Y.; Harrison, Benjamin S.

doi:10.1016/j.msec.2015.04.001

Cited by 11 publications

(7 citation statements)

References 16 publications

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“…In electrospun scaffolds, small diffusion distances and high surface area allow for a drastically reduced response times as we and others have previously shown. [25,30,45,50,51] The response curve upon switching between oxygen and nitrogen gas has been shown to be rapid and repeatable. [30] Response times for core-shell fibers have been found to be < 0.1 s, short enough to make these sensors useful for real-time, continuous monitoring of oxygen concentration under dynamic conditions.…”

Section: Discussionmentioning

confidence: 99%

Nanoscale upconversion for oxygen sensing

Presley

Hwang

Cheong

et al. 2017

Materials Science and Engineering: C

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Optical oxygen sensors have many promising qualities but rely on excitation by violet or blue wavelengths that suffer from high levels of scattering and absorption in biological tissues. Here we demonstrate an alternative method using 980nm near-infrared light to initially stimulate ceramic upconverting nanoparticles (UCNPs) contained within a novel form, electrospun core-shell fibers. The emission of the UCNPs excites a molecular optical oxygen sensor, the subsequent phosphorescent emission being dynamically quenched by the presence of molecular oxygen. The potential for use of such an energy transfer within electrospun fibers widely used in biological applications is promising. However, current knowledge of such 'handshake' interactions is limited. Fiber-based carriers enabling such optical conversions provide unique opportunities for biosensing as they recapitulate the topography of the extracellular matrix. This creates a wide array of potential theranostic, fiber-based applications in disease diagnosis/imaging, drug delivery and monitoring of therapeutic response. Using a fiber-based vehicle, we observed gaseous oxygen sensing capabilities and a linear Stern-Volmer response allowing highly accurate calibration. Configurational aspects were also studied to determine how to maximize the efficiency of this 'handshake' interaction.

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Section: Discussionmentioning

confidence: 99%

Nanoscale upconversion for oxygen sensing

Presley

Hwang

Cheong

et al. 2017

Materials Science and Engineering: C

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“…The fluorescent sensing film is the most important part of the DO sensor and its performance significantly influences the accuracy, efficiency, and stability of the sensor. Researchers have conducted several studies on fluorescence indicators [ 20 , 21 , 22 ] and found that the most common fluorescent indicators contain metal porphyrin complexes, organic polycyclic aromatic hydrocarbons, and transition metal complexes [ 23 ]. Ru(bpy) 3 Cl 2 has been chosen as the fluorescence indicator in this study because of its highly emissive metal-to-ligand charge-transfer state, long lifetime, and strong absorption in the blue-green region of the spectrum, which is compatible with the high-brightness blue LED [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…With the rapid development of computers, communications, and networks, the DO sensor should be more intelligent, networked, and integrated [ 20 ]. To solve the problems of traditional optical sensors, the intelligent optical DO sensor proposed in this study is developed with automatic compensations, which are suitable for the online detection of aquaculture over long periods.…”

Section: Methodsmentioning

confidence: 99%

An Intelligent Optical Dissolved Oxygen Measurement Method Based on a Fluorescent Quenching Mechanism

Wei

Chen

et al. 2015

Sensors

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Dissolved oxygen (DO) is a key factor that influences the healthy growth of fishes in aquaculture. The DO content changes with the aquatic environment and should therefore be monitored online. However, traditional measurement methods, such as iodometry and other chemical analysis methods, are not suitable for online monitoring. The Clark method is not stable enough for extended periods of monitoring. To solve these problems, this paper proposes an intelligent DO measurement method based on the fluorescence quenching mechanism. The measurement system is composed of fluorescent quenching detection, signal conditioning, intelligent processing, and power supply modules. The optical probe adopts the fluorescent quenching mechanism to detect the DO content and solves the problem, whereas traditional chemical methods are easily influenced by the environment. The optical probe contains a thermistor and dual excitation sources to isolate visible parasitic light and execute a compensation strategy. The intelligent processing module adopts the IEEE 1451.2 standard and realizes intelligent compensation. Experimental results show that the optical measurement method is stable, accurate, and suitable for online DO monitoring in aquaculture applications.

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“…Both PCL and PEO are extensively studied polymers for electrospinning due to their biocompatibility and biodegradability [ 43 , 44 , 45 , 46 ]. Several publications utilized PCL and PEO polymers as amphiphilic nanofiber substrates [ 31 , 35 , 47 , 48 , 49 , 50 ]. The studies have shown auspicious properties, such as very good biocompatibility [ 36 ], tunable drug release profiles [ 29 ], and the differentiation of mesenchymal stem cells on the nanofiber substrates [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

Well-Blended PCL/PEO Electrospun Nanofibers with Functional Properties Enhanced by Plasma Processing

et al. 2020

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Biodegradable composite nanofibers were electrospun from poly(ε-caprolactone) (PCL) and poly(ethylene oxide) (PEO) mixtures dissolved in acetic and formic acids. The variation of PCL:PEO concentration in the polymer blend, from 5:95 to 75:25, revealed the tunability of the hydrolytic stability and mechanical properties of the nanofibrous mats. The degradation rate of PCL/PEO nanofibers can be increased compared to pure PCL, and the mechanical properties can be improved compared to pure PEO. Although PCL and PEO have been previously reported as immiscible, the electrospinning into nanofibers having restricted dimensions (250–450 nm) led to a microscopically mixed PCL/PEO blend. However, the hydrolytic stability and tensile tests revealed the segregation of PCL into few-nanometers-thin fibrils in the PEO matrix of each nanofiber. A synergy phenomenon of increased stiffness appeared for the high concentration of PCL in PCL/PEO nanofibrous mats. The pure PCL and PEO mats had a Young’s modulus of about 12 MPa, but the mats made of high concentration PCL in PCL/PEO solution exhibited 2.5-fold higher values. The increase in the PEO content led to faster degradation of mats in water and up to a 20-fold decrease in the nanofibers’ ductility. The surface of the PCL/PEO nanofibers was functionalized by an amine plasma polymer thin film that is known to increase the hydrophilicity and attach proteins efficiently to the surface. The combination of different PCL/PEO blends and amine plasma polymer coating enabled us to tune the surface functionality, the hydrolytic stability, and the mechanical properties of biodegradable nanofibrous mats.

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Morphology impact on oxygen sensing ability of Ru(dpp)3Cl2 containing biocompatible polymers

Cited by 11 publications

References 16 publications

Nanoscale upconversion for oxygen sensing

Nanoscale upconversion for oxygen sensing

An Intelligent Optical Dissolved Oxygen Measurement Method Based on a Fluorescent Quenching Mechanism

Well-Blended PCL/PEO Electrospun Nanofibers with Functional Properties Enhanced by Plasma Processing

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