Morphology and Physiology of Ghrih (Somatostatin) in the Gastrointestinal Tract

Polak, Julia M.; Bloom, Stephen R.; Joffe, Stephen N.; Pearse, A. G. E.

doi:10.1042/cs049026pb

Cited by 3 publications

(10 citation statements)

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“…6). These findings are in agreement with the published information in the anaesthetized pig (Polak et al 1975). However, some authors have reported that Somatostatin does inhibit secretin stimulated pancreatic juice volume in conscious man and dog (Creutzfeldt, 1976;Konturek et al 1976b).…”

Section: Discussionsupporting

confidence: 93%

“…We have reported an inhibition of CCK-PZ stimulated gall bladder contraction (Fig. 6) a finding confirming that of Polak et al (1975) in the anaesthetized pig. No direct evidence has been reported on the effect of Somatostatin on gall bladder contraction in conscious animals.…”

Section: Discussionsupporting

confidence: 84%

“…Somatostatin has been reported to reduce secretin stimulated pancreatic juice volume in man (Creutzfeldt, 1976) and the conscious dog (Konturek, Tasler, Obtulowicz, Coy & Schally, 1976b). Conversely, Polak, Bloom, Joffe & Pearse (1975) reported no effect on secretin stimulated pancreatic bicarbonate juice production in the anaesthetized pig, an effect agreeing with an observation in man (Dollinger, Raptis, Goebell & Pfeiffer, 1976). Secretin stimulated electrolyte output has been reported to be decreased by Somatostatin in dog (Konturek et al 1976b), and man (Creutzfeldt, 1976), and unchanged in man (Dollinger et al 1976).…”

Section: Introductionmentioning

confidence: 64%

“…Robberecht, Deschodt-Lanckman, DeNeef & Christophe (1975) reported unstimulated pancreatic enzyme secretion to be increased by Somatostatin in the in vivo and in vitro rat preparation. Secretin release, as judged by the stimulation of pancreatic juice flow to acidification of the duodenum, has been reported to be inhibited in the conscious dog (Konturek et al 1976b) and unaffected in the unaesthetized pig (Polak et al 1975). Serum immunoreactive secretin release stimulated by intraduodenal hydrochloric acid in the conscious dog has been reported to be completely suppressed by Somatostatin (Boden, Sivitz, Owen, Essa-Koumar & Landor, 1975).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.

Albinus¹,

Blair²,

Case³

et al. 1977

The Journal of Physiology

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SUMMARY1. Somatostatin, 10 jug kg-1 hr-1, inhibited gastric acid and pepsin secretion stimulated by pentagastrin, 8 ,g kg-1 hr-1, in conscious and anaesthetized cats with chronically implanted gastric fistulae. In the acutely surgically prepared anaesthetized cat, Somatostatin inhibited pepsin secretion but produced little inhibition of gastric acid secretion or mucosal blood flow.2. Secretin stimulated pancreatic juice volume was not significantly reduced in acutely prepared anaesthetized cats, but there was a limited reduction of cholecystokinin-pancreozymin stimulated pancreatic amylase secretion and gall bladder contraction.3. Somatostatin had neither stimulatory nor inhibitory effects on electrolyte and amylase secretion in the isolated saline-perfused cat pancreas.4. The results suggest that some of the effects of Somatostatin may depend on the interaction on the target cell of other factors, nervous or humoral which may vary in different experimental preparations.t Present address:

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.

Albinus¹,

Blair²,

Case³

et al. 1977

The Journal of Physiology

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“…It has been reported that basal secretion was inhibited in the dog (3), unaffected in man (25) and increased in the rat (26). Secretin-stimulated secretion (volume and bicarbonate output) is reported by some authors to have been reduced in man (7,10) and in the dog (18), whereas others report no discernable somatostatin action in man (9), pig (24) and the anaesthetized cat (1). Protein outputs in response to secretin were observed to be either unaffected (18) or greatly reduced (3,10,20) by somatostatin administration.…”

mentioning

confidence: 93%

Inhibition of Exocrine Pancreatic Secretion by Somatostatin in Dogs

Susini¹,

Estève²,

Bommelaer³

et al. 1978

Digestion

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The effect of somatostatin on the pancreatic exocrine response to different doses of exogenous stimuli and the somatostatin dose-response relationships on pancreatic secretion were studied in conscious dogs. Somatostatin caused a strong inhibition of basal or slightly stimulated pancreatic secretion but failed to inhibit the maximal responses, suggesting that somatostatin interacts with secretin or caerulein by a competitive mechanism. A higher maximal percentage of inhibition and a dose-response relationship was observed with protein outputs and enzyme concentrations. Volumes and bicarbonate outputs were also inhibited but the maximal percentage of inhibition was lower.

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Neurogenic-genetic theory of etiology peptic ulcer disease

Ivanov,

Kolotilova

2024

ECG

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The purpose of the study. Improvement of the author's Neurogenic-genetic theory of the etiology of the pathogenesis of peptic ulcer disease. Materials and methods: To develop the author's view on the etiology and pathogenesis of peptic ulcer disease, about 50 different publications were processed and the results of their own research were analyzed. Results. Consequently, the neurogenic-genetic theory of the etiology and pathogenesis of gastric and duodenal ulcer very optimally explains the cause-and-effect relationships in a patient with ULCER, allowing for variants of the prevalence of neurosis factor or local genetic factors in one case or another. However, another thing is obvious, that only a combination of a neurogenic factor with a genetically altered reactivity of the gastroduodenal system (the presence of a target organ) causes the chronic ulcers. The theory of peptic ulcer disease developed by us, as a disease related to psychosomatic pathology, allows us to develop effective therapy, including drugs with a psychocorregulating effect.

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Morphology and Physiology of Ghrih (Somatostatin) in the Gastrointestinal Tract

Cited by 3 publications

References 0 publications

Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.

Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.

Inhibition of Exocrine Pancreatic Secretion by Somatostatin in Dogs

Neurogenic-genetic theory of etiology peptic ulcer disease

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