Morphology and immunohistochemistry of the caudal neurosecretory system in tetraodontids

Cioni, Carla; Bordieri, Loredana

doi:10.1080/11250000309356488

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Therefore, the BrdUlabeled cells might partially be the regenerative neuroblasts, and the increased UI-positive Dahlgren cells might not be differentiated from newly regenerative neuroblast cells. Previous morphology and immunohistochemistry studies of the CNSS have found that CRH and UI were co-expressed (Cioni and Bordieri, 2003;Lu et al, 2004). Meanwhile, UI and UII could also be co-expressed in a fraction of Dahlgren cells (Parmentier et al, 2006).…”

Section: Discussionmentioning

confidence: 87%

“…However, until now, it was not known whether alterations in temperature would affect the number of Dahlgren cells and their associated secretions. Morphology and immunohistochemistry studies of the CNSS suggested that CRH, UI and UII were produced and secreted from the Dahlgren cells in the CNSS (Cioni and Bordieri, 2003;Lu et al, 2004). Therefore, the number of CRH-, UI-and UII-positive Dahlgren cells could represent the required secretory level of these genes in CNSS.…”

Section: Discussionmentioning

confidence: 99%

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Dynamic Responses of the Caudal Neurosecretory System (CNSS) Under Thermal Stress in Olive Flounder (Paralichthys olivaceus)

Yuan

Long

et al. 2020

Front. Physiol.

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Temperature is a critical environmental factor that affect most biological and physiological processes in fish. The caudal neurosecretory system (CNSS) is unique to fish and is proved to maintain homeostasis during seasonal alterations. However, the dynamic expression and secretion pattern of its major hormones, corticotrophinreleasing hormone (CRH), urotensin I (UI), and urotensin II (UII), and their response to thermal stress has not been studied. CRH, UII and cortisol in plasma, gene expression levels of CRH, UI, and UII in the CNSS of olive flounder (Paralichthys olivaceus) were therefore characterized. UI-and UII-positive Dahlgren cells, as well as cell proliferation in the CNSS, were also quantified. The results showed that plasma cortisol and CRH were increased in both low temperature (LT) and high temperature (HT) groups. However, there was no difference in plasma UI and UII during thermal stress. In CNSS, CRH, UI, and UII mRNA levels were all significantly elevated in response to acute hypothermal stress and recovered back to the control (normal) level after 8 days of adaptation. During hyperthermal challenge, gene expression of CRH and UI only significantly increased after 8-days of transfer but no change in UII was observed. We also demonstrated an increasing percent of UI-positive Dahlgren cells in the CNSS of 8-days hyperthermal stressed fish. However, no BrdU-labeled Dahlgren cells were found among the three treatment groups. Collectively, our results demonstrate that the CNSS is subjected to dynamic responses under thermal stress and expands upon the role of the CNSS in thermoregulation. The dynamic responses of hormone levels and the gene expression of CRH, UI and UII in CNSS are all involved in the process of hyper-or hypo-thermal stress and adaptation.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Dynamic Responses of the Caudal Neurosecretory System (CNSS) Under Thermal Stress in Olive Flounder (Paralichthys olivaceus)

Yuan

Long

et al. 2020

Front. Physiol.

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The Caudal Neurosecretory System: A Still Enigmatic Second Neuroendocrine Complex in Fish

Rousseau,

Girardot,

Parmentier

et al. 2024

Neuroendocrinology

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The caudal neurosecretory system (CNSS) is a neuroendocrine complex, whose existence is specific to fishes. In teleosts, it consists of neurosecretory cells (Dahlgren cells) whose fibers are associated with a neurohemal terminal tissue (urophysis). In other actinopterygians as well as in chondrichthyes, the system is devoid of urophysis, so that Dahlgren cells end in a diffuse neurohemal region. Structurally, it has many similarities with the hypothalamic-neurohypophysial system. However, it differs regarding its position at the caudal end of the spinal cord and the nature of the hormones it secretes, the most notable ones being urotensins. The CNSS was first described more than 60 years ago, but its embryological origin is still hypothetical, and its role is poorly understood. Observations and experimental data gave some evidences of a possible involvement in osmoregulation, stress, and reproduction. But one may question the benefit for fish to possess this second neurosecretory system, while the central hypothalamic-pituitary complex already controls such functions. As an introduction of our review, a brief report on the discovery of the CNSS is given. A description of its organization follows, and our review then focuses on the neuroendocrinology of the CNSS with the different factors it produces and secretes. The current knowledge on the ontogenesis and developmental origin of the CNSS is also reported, as well as its evolution. A special focus is finally given on what is known on its potential physiological roles.

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Morphology and immunohistochemistry of the caudal neurosecretory system in tetraodontids

Cited by 2 publications

References 30 publications

Dynamic Responses of the Caudal Neurosecretory System (CNSS) Under Thermal Stress in Olive Flounder (Paralichthys olivaceus)

Dynamic Responses of the Caudal Neurosecretory System (CNSS) Under Thermal Stress in Olive Flounder (Paralichthys olivaceus)

The Caudal Neurosecretory System: A Still Enigmatic Second Neuroendocrine Complex in Fish

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