Morphology and function of human benign tumors and normal thyroid tissues maintained in severe combined immunodeficient mice

Fukuda, Kentarou; Nakajima, Hiroo; Taniguchi, Eiji; Sutoh, Kazuo; Wang, H; Hande, M. Prakash; Li, L.Y; Kurooka, Masayuki; Mori, Katsumi; Hongyo, Tadashi; Kubo, Takeshi; Nomura, Taisei

doi:10.1016/s0304-3835(98)00169-4

Cited by 12 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the endometrial tissue retained functional responsiveness to hormonal manipulation after progesterone supplementation. Fukuda et al 23 studied the morphology and function of normal thyroid tissue in SCID mice and found similar results. The thyroid tissue maintained viability up to 3 y and retained the ability to sequester radioiodine and secrete thyroid hormone in response to thyroid stimulating hormone administration.…”

Section: Discussionmentioning

confidence: 70%

“…It has served as a well-recognized animal model for malignant disease and hematological disorders but more recently has been used in the study of benign diseases. [20][21][22][23]25 Awwad et al 22 in an attempt to develop an animal model for endometriosis, studied the results of blind intra-peritoneal injection of endometrial tissue into SCID mice. They found a 96% successful implantation rate and conservation of normal morphologic features on staining of the tissue.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 SCID mice have also been used in the exploration of benign diseases. 22,23 Cells that demonstrate tumorigenic potential are by definition biologically transformed. The purpose of this investigation was to determine if fibroblasts derived from Peyronie's disease plaque tissue possess tumorigenic potential in the SCID mouse model and thus, determine definitively if these cells are biologically transformed.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peyronie's disease fibroblasts demonstrate tumorigenicity in the severe combined immunodeficient (SCID) mouse model

Martín

Lubrano

et al. 2004

Int J Impot Res

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peyronie's disease fibroblasts demonstrate tumorigenicity in the severe combined immunodeficient (SCID) mouse model

Martín

Lubrano

et al. 2004

Int J Impot Res

View full text Add to dashboard Cite

“…[7][8][9][10][11] In the present study, after establishing a xenograft model of human BPH implanted subcutaneously in super-SCID mice, we evaluated histologic changes in human prostate tissue caused by dutasteride.…”

Section: Resultsmentioning

confidence: 99%

Histologic Evaluation of Human Benign Prostatic Hyperplasia Treated by Dutasteride: A Study by Xenograft Model With Improved Severe Combined Immunodeficient Mice

Tsujimura

Fukuhara

Soda

et al. 2015

Urology

View full text Add to dashboard Cite

“…161 Indeed, explants of benign head and neck tumor tissue have been maintained subcutaneously in SCID mice for up to 3 years, while conserving their morphological and functional characteristics. 162 In addition, and perhaps most importantly, the unique ability of the SCID mouse to support xenografted lymphocytes offers the possibility of examining the interactions between human lymphocytes and human tumors in vivo. 158,163,164 The transplantation of human tumor tissue in combination with functional elements of the human immune system was first demonstrated in a lung cancer model, 163,164,165 and later extended to include human head and neck cancer.…”

Section: Orthotopic Modifications Of the Original Nude Mouse Modelmentioning

confidence: 99%

Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: A historical perspective with review of their utility and limitations. Part A. Chemically‐induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors

Smith

Thomas

2005

Intl Journal of Cancer

View full text Add to dashboard Cite

Understanding the complex histological, genetic and molecular changes that lead to malignant transformation of squamous epithelia of the head and neck will likely guide the development of methods for improved diagnosis, monitoring and treatment of head and neck squamous cell carcinoma (HNSCC). The development and use of animal models that closely mimic the histopathology and molecular pathogenesis of HNSCC in humans would greatly expand the research possibilities and provide a means of testing potential therapeutic agents. However, many available animal models of HNSCC fall short of this objective. In order for investigators to select the appropriate model to answer scientific questions, it is important to understand the benefits and limitations of available animal models for the study of HNSCC. The purpose of this work is to give an overview of the most pertinent animal models of HNSCC, and to discuss future directions of research in this field. ' 2005 Wiley-Liss, Inc.Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. Approximately half of all patients with HNSCC have advanced stage disease at the time of diagnosis, with an expected 5-year survival rate between 10 and 40%.1 Despite treatments that may consist of mutilating surgery, radiotherapy and/or chemotherapy, overall long-term survival remains low due to uncontrollable persistent or recurrent disease. The survival rate of patients with locoregional and distant recurrences has highlighted the need for new approaches for diagnosis and treatment. To this end, a better understanding of the genetic, molecular and immunoregulatory processes leading to neoplastic transformation and progression of HNSCC is needed, so that novel and more effective diagnostic and therapeutic approaches can be designed.Although in vitro study systems are useful for studying the interactions between different cell populations in culture and are convenient and simple to use, they do not reproduce the complexity of HNSCC. For this reason, the development of new therapies will require clinically relevant animal models of HNSCC. Adequate animal models are necessary to test the translational potential of preventive and therapeutic agents, as well as to understand the biological mechanisms of epithelial carcinogenesis and progression. The ideal experimental animal tumor model for HNSCC must reproduce the characteristic features of the disease, including the complicated patterns of tumor-host interactions such as immune response, angiogenesis, invasion and metastasis. In the ideal model, clinical symptoms and laboratory abnormalities should be similar to the human disease and therapeutic agents should be as effective in both systems. The ideal model must also be easy to use, accessible to genetic and immunologic manipulations, reproducible and progress rapidly to allow timely investigations.Animal mod...

show abstract

Morphology and function of human benign tumors and normal thyroid tissues maintained in severe combined immunodeficient mice

Cited by 12 publications

References 9 publications

Peyronie's disease fibroblasts demonstrate tumorigenicity in the severe combined immunodeficient (SCID) mouse model

Peyronie's disease fibroblasts demonstrate tumorigenicity in the severe combined immunodeficient (SCID) mouse model

Histologic Evaluation of Human Benign Prostatic Hyperplasia Treated by Dutasteride: A Study by Xenograft Model With Improved Severe Combined Immunodeficient Mice

Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: A historical perspective with review of their utility and limitations. Part A. Chemically‐induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors

Contact Info

Product

Resources

About