Morphology and digitally aided morphometry of the human paracentral lobule

Spasojević, Goran; Malobabić, Slobodan; Pilipović-Spasojević, Olivera; Djukic-Macut, Natasa; Maliković, Aleksandar

doi:10.5603/fm.2013.0002

Cited by 32 publications

(29 citation statements)

References 21 publications

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“…Also, the paracentral lobule is located in the posterior part of the frontal lobe and in the anterior part of the parietal lobe. Its anterior part is located in the primary motor cortex ( Spasojević et al, 2013 ) (Brodmann area 4) and is involved in voluntary movements. In particular, this region plays a role in voluntary movements of contralateral leg and foot.…”

Section: Discussionmentioning

confidence: 99%

Reorganization of the structural connectome in primary open angle Glaucoma

Ciò

Garaci

Minosse

et al. 2020

NeuroImage: Clinical

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Highlights Primary Open Angle Glaucoma is one of the major causes of blindness worldwide. Structural connectivity and graph theory allow to analyse brain network changes. Disruption index is able to estimate the reorganization of nodal network topology. The global network of Primary open angle Glaucoma patients is highly reorganized. Primary open angle glaucoma could be considered a neurodegenerative disease.

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Section: Discussionmentioning

confidence: 99%

Reorganization of the structural connectome in primary open angle Glaucoma

Ciò

Garaci

Minosse

et al. 2020

NeuroImage: Clinical

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“…In a high-definition MRI study by Spasojević et al comparing the right and left areas of the paracentral lobes in 84 hemispheres, the mean extrasulcal surface of the left paracentral lobule was significantly larger, both in males (left 6.79 cm 2 vs. right 5.76 cm 2 ) and in females (left 6.05 cm² vs. right 5.16 cm²) 7 .…”

Section: Discussionmentioning

confidence: 99%

Morphometric analyses of the Paracentral Lobe.

et al. 2014

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Introduction: There are no studies that evaluate the measurements of the distances between the grooves that demarcate the Paracentral Lobule (PCL) in literature. This study seeks to contribute to the knowledge regarding the anatomy of the PCL, conducting an analysis of morphometric measurements in this region and its correlation with the paracentral sulcus, marginal branch of the cingulate and central sulci. Methods: 42 hemispheres were evaluated, 22 from the right and 20 from the left hemisphere. Using a digital caliper rule Western ®, model Dc -6, measurements of the size of Paracentral Lobe in the sagittal axis and coronal axis were made, in addition to measures of the Central Sulcus to the Paracentral Sulcus (motor area) and Central Sulcus to Marginal Branch of the Cingulate Sulcus (somesthetic area), comparing the prevalence of each of these lengths between hemispheres. Results: The average length between the Paracentral Sulcus and the Central Sulcus was 24.49 cm (14.2 to 38.6 cm) in the right hemisphere and 25.50 cm (11.7 to 37.0 cm) in the left. As between the Central Sulcus and the Marginal Branch of the Cingulate Sulcus was in average 10.03 cm (2.6 to 22.7 cm) in the right and in the left PCL 9.17cm (2.6 to 22.7 cm). In the right hemisphere, 19 samples (86,4%) presented greater length of the motor area than somesthetic, and, in the left hemisphere, 19 samples (95%) had greater length of the motor area. Conclusion:The motor area showed larger size in relation to the sensory area in the analysis of the two hemispheres, while the comparison of other measures between the two hemispheres showed no significance.

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“…In fact, the PoCG, as the main sensory receptive area, is one of the major regions affected in CSM patients, 33 while the PCL controls motor and sensory innervations. 34 In a resting-state fMRI study of CSM, one explanation of increased connectivity is a negative “side effect” in the context of lost sensory impulses. 1 , 6 Hyper-perfusion in the aforementioned regions further supports the “adaptive plasticity” hypothesis posed by Zhou et al 1 derived from the blood flow profile.…”

Section: Discussionmentioning

confidence: 99%

“… 11 , 18 Another explanation is that a loss of afferent sensory conditions may result in less efficient funneling of neural processing. 34 …”

Section: Discussionmentioning

confidence: 99%

Altered perfusion of the sensorimotor cortex in patients with cervical spondylotic myelopathy: an arterial spin labeling study

Zhou

Huang

et al. 2018

JPR

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ObjectiveAdvanced magnetic resonance imaging studies have shown functional plasticity or reorganization and metabolite alterations of N-acetyl aspartate in the sensorimotor cortex (SMC), a hallmark region and key brain network, in patients with cervical spondylotic myelopathy (CSM). However, the nature of perfusion in the SMC and the relationship between regional cerebral blood flow (CBF), motor function scores, and structural damage of the cervical cord in patients with CSM are not fully understood.Materials and methodsAll right-handed participants underwent pseudo-continuous arterial spin labeling pulse sequence scanning, and CBF was then calculated and compared between CSM and healthy groups. Clinical and structural associations were assessed in the SMC. Receiver operating characteristic (ROC) and leave-one-out cross-validation analyses were used to estimate the sensitivity and specificity of the significantly altered CBF in the SMC to distinguish myelopathy-related impairment.ResultsA total of 18 pairs of CSM patients and well-matched healthy subjects were included in the analyses. Compared with healthy subjects, CSM patients exhibited significantly decreased CBF in the left premotor ventral/precentral operculum (PMv/PrCO) and the bilateral dorsal anterior cingulate cortex (dACC); and increased CBF in the left paracentral lobule (PCL), the right PCL/supplementary motor area (PCL/SMA), and the right postcentral gyrus (PoCG; Gaussian random field correction at P<0.01). In the CSM group, the CBF values in the right PoCG were negatively correlated with Japanese Orthopaedic Association scores, and the CBF values in several regions were negatively correlated with Neck Disability Index scores. Finally, the ROC analysis revealed that significantly increased CBF in the left PCL, the right PCL/SMA, and the right PoCG discriminated patients with myelopathy-related impairment from healthy subjects.ConclusionRegional CBF was reduced in operculum-integrated (PMv/PrCO) and motor control (dACC) regions but increased in sensory (PoCG) and motor-sensory processing (PCL/SMA) regions in patients with CSM.

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Morphology and digitally aided morphometry of the human paracentral lobule

Abstract: (Folia Morphol 2013; 72, 1: 10-16)

Cited by 32 publications

References 21 publications

Reorganization of the structural connectome in primary open angle Glaucoma

Reorganization of the structural connectome in primary open angle Glaucoma

Morphometric analyses of the Paracentral Lobe.

Altered perfusion of the sensorimotor cortex in patients with cervical spondylotic myelopathy: an arterial spin labeling study

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