Morphologische und experimentelle Untersuchungen �ber das hypothalamisch-hypophys�re System

Bargmann, W.; Hild, Walther; Ortmann, R.; Schiebler, T. H.

doi:10.1007/bf01226918

Cited by 128 publications

(6 citation statements)

References 22 publications

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“…1). Many of the cells of the nucleus were located in close proximity to the blood capillaries: the fact was frequently reported by the previous workers (Scharrer and Gaupp, 1933;Scharrer, 1936;1941;Foley, Kinney and Alexander, 1942;Bargmann, et al, 1950;Ortmann, 1951;Enami and Imai, 1955). In some of the cells of the paraventricular nucleus, intracellular vacuoles were observed at the site of the peripheral Nissl area, in which CH-positive material was abundant (Fig.…”

Section: Observationsupporting

confidence: 53%

Neurosecretory Phenomenon of the Paraventricular Nucleus in a Senile Woman

Shimoda

1958

Endocrinol Japon

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Section: Observationsupporting

confidence: 53%

Neurosecretory Phenomenon of the Paraventricular Nucleus in a Senile Woman

Shimoda

1958

Endocrinol Japon

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“…Another factor which may contribute to the uniqueness of potentials recorded from neurosecretory cells is the morphological change due to accumulation of secretary granules (Bargmann, 1949;Bargmann, Hild, Ortman & Schiebler, 1965). It has been stated that the axon hillock of a KIYOMI KOIZUMI AND H. YAMASHITA neurosecretory cell may contain such large numbers of secretary granules that this part often appears 'nodose and torturous' (Gabe, 1966).…”

Section: Uniqueness Of Action Potentials Of Neurosecretory Cellsmentioning

confidence: 99%

“…Another factor which may contribute to the uniqueness of potentials recorded from neurosecretory cells is the morphological change due to accumulation of secretary granules (Bargmann, 1949;Bargmann, Hild, Ortman & Schiebler, 1965 (Gabe, 1966). Such a morphological change might alter the normal process of impulse invasion of the neurosecretory cell.…”

Section: Uniqueness Of Action Potentials Of Neurosecretory Cellsmentioning

confidence: 99%

Studies of antidromically identified neurosecretory cells of the hypothalamus by intracellular and extracellular recordings

Koizumi¹,

Yamashita²

1972

The Journal of Physiology

154

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SUMMARY1. Neurosecretory neurones in supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus of cats, anaesthetized with chloralose, and dogs, anaesthetized with Nembutal, were studied. These neurosecretory neurones were identified by action potentials evoked antidromically following stimulation of the posterior lobe of the pituitary gland. Reactions of 158 such neurones in cats and 228 in dogs were analysed.2. The latencies of antidromic potentials evoked in neurosecretory neurones by posterior lobe stimulation were between 10 and 22 msec for SON and between 14 and 28 msec for PVN cells. Approximate speed of conduction in the axons was 0 4-0 9 m/sec. The absolute refractory period for the soma-dendritic (SD) spike was 5-10 msec. These cells followed repetitive stimulation up to a rate of 100/sec.A notch was generally present on the rising phase of antidromic potentials and when the antidromically conducted signal fell in the relative refractory period of the preceding response, a complete separation between this first small A-spike and later large B-spikes, probably soma-dendritic spike, frequently occurred. Thus, two responses, a small and a large, sometimes appeared with more than 10 msec intervening. When the second antidromic response fell in the absolute refractory period of the first, the B-spike was blocked and only the A-spike appeared.3. Intracellular recordings from neurosecretory cells, mainly from SON in the dog, showed that these neurones possess resting membrane potentials of 50-80 mV, and action potentials of the same magnitude.In spontaneously firing neurosecretory cells separate A-and B-spikes also occurred and could be recorded intracellularly. three spikes with latencies of 10-30 msec. Excitation was followed by an inhibition, of 'spontaneous' discharges as well as of subsequent antidromic excitation, lasting 100-500 msec. Intracellular recordings from neurosecretory cells showed that stimulations of the septal area and RF produced action potentials or EPSPs of short duration followed by long lasting IPSPs. Hyperpolarization was always longer than the preceding EPSP, and its duration was generally 80 msec. Large IPSPs of 20 mV could be recorded occasionally.7. Antidromic excitation of neurosecretory cells by stimulation of the posterior pituitary was followed by the inhibition of 'spontaneous' discharges of the cells. This inhibition usually lasted for 100 msec. A corresponding IPSP was recorded during this inhibitory phase. These findings indicate the existence of recurrent collaterals in neurosecretory cells.8. This conclusion that recurrent collaterals exist was also supported by other evidence, namely, that certain neurones were found in the SON and PVN which responded to a single pulse antidromic stimulation of the posterior pituitary with five to seven discharges at a rate of between 500 and 800/sec. Weaker stimuli produced fewer spikes. Such cells resembled in their behaviour 'Renshaw cells' of the spinal cord. RF stimulation had an inhibitory effect on some of these neur...

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“…There is considerable evidence to suggest that the stainable 'neurosecretory' material of the neurohypophysis is related to the antidiuretic hormone [Ortmann, 1950;Schiebler, 1951Schiebler, , 1952Hild & Zetler, 1953a;Barrnett, 1954;Hild, 1954;Sloper, 1954Sloper, , 1955Adams & Sloper, 1955Howe & Pearse, 1956 , ] and, further, that the quantity of material demonstrable can be greatly modified by altering the state of hydration of the animal [Bargmann, Hild, Ortmann & Schiebler, 1950;Ortmann, 1950Ortmann, , 1951Kovács, Bachrach, Oláh & Varrò, 1952;Hild & Zetler, 1953 ;Leveque & Scharrer, 1953;Bachrach, Kovács, Traub, Horváth & Korpássy, 1954;Barrnett, 1954;Kovács, Bachrach, Jakobovits, Horváth & Korpássy, 1954;Adams & Sloper, 1956;Andersson & Jewell, 1957].…”

mentioning

confidence: 99%

Effects of Water Deprivation Upon the Neurosecretory Material of the Desert Rat (Meriones Meriones) Compared With the Laboratory Rat

Howe¹,

Jewell²

1959

Journal of Endocrinology

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The effects of dehydration, brought about by water deprivation over a period of 10 days, upon the stainable neurosecretory material (NSM) of the hypothalamo-hypophysial system were compared in two species of rodents originating from different climatic habitats, namely the laboratory rat (Rattus norvegicus) and the desert rat (Meriones meriones).While the neural lobe of the laboratory rat was virtually completely depleted of NSM by this procedure, that of the desert rat showed no detectable histological changes. No striking changes were found in the hypothalamus of either species following this period of water deprivation, although there was some indication of disappearance of NSM from the hypothalamus in the desert rat.The results are briefly discussed in relation to the theory of hypothalamic neurosecretion.

show abstract

Morphologische und experimentelle Untersuchungen �ber das hypothalamisch-hypophys�re System

Cited by 128 publications

References 22 publications

Neurosecretory Phenomenon of the Paraventricular Nucleus in a Senile Woman

Neurosecretory Phenomenon of the Paraventricular Nucleus in a Senile Woman

Studies of antidromically identified neurosecretory cells of the hypothalamus by intracellular and extracellular recordings

Effects of Water Deprivation Upon the Neurosecretory Material of the Desert Rat (Meriones Meriones) Compared With the Laboratory Rat

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