Morphologische Äquivalente bei Rhythmusstörungen des Herzens

Humoral immune response to cardiac conducting tissue

“…At least two different antibodies were detected by absorption experiments; one, which is cross-reactive or absorbable with ventricular myocardium and another, which is specific for the sinus or AV node. The simultaneous staining of the sinus and AV node in patients with binodal disease suggests, that the underlying pathogenetic process may not only affect the sinus node but also the AV node or other parts of the conducting tissue [12,15,16,55,57].…”

“…Idiopathic fibrosis of the sinus node, mostly described as age-related [15], deposits of amyloid staining material [47] or replacement of the sinus node tissue by fat [27] was also observed. Even lymphocytic infiltration Offprint requests to: U. Lotze may occur [16,55]. There is still controversy as to whether coronary artery disease should be considered as the main cause leading to SSS [15,17,55], since there is evidence of SSS evoked by degenerative processes within the sinus node independent from a significant stenosis of the sinus node artery or its supplying coronary artery [12,17,55,57,59].…”