“…In the CIBA-classification, for instance, a very considerable part of the important cases will be found within the unclassified group, while advanced cases with centrilobular beginnings might erroneously be put into the panlobular group. Bullous emphysema, which often exceeds the lobular limits, may be the result of advanced centrilobular emphysema as well as of a progressive lung tissue atrophy [9,30] as in senile emphysema, which the CIBA-classifica tion altogether disavows though it is suspected to appear within the panlobular group. Moreover the recent work of Wyatt, Pratt and others on clinico-pathologic correlation [23, 24, 27-29, 32, 33] does not seem to have succeeded in demonstrating panacinar and centri lobular forms of emphysema as clinical entities, nor as specified types in post mortem function tests.…”