Morphological, thermal, and blood‐compatible properties of electrospun nanocomposites for tissue engineering application

Abstract

In this work, the morphological, thermal, and blood compatibility properties of prepared polyurethane (PU) and gandharvahasthadi eranda thailam (GHT) nanocomposites were investigated. Morphological and thermal characterization revealed reduced diameter, improved surface roughness, and higher thermal degradation compared to control. The activated partial thromboplastin time (APTT) and prothrombin time (PT) assay revealed that the fabricated nanocomposites displayed delayed blood clotting time owing to improved surface morphology. The hemolytic assay suggested that nanocomposites would be nonhemolytic material due to low hemolytic index of about 1.15% compared to pure PU (2.733%) portraying its safety with the red blood cells. Thus, the newly developed PU/GHT composite scaffold possessing better physicochemical and blood compatibility may be considered as a potential substitute scaffold for replacing damaged tissue. POLYM. COMPOS., 39:E132–E139, 2018. © 2017 Society of Plastics Engineers

Synthesis and characterization of Zn doped WO3 nanoparticles: photocatalytic, antifungal and antibacterial activities evaluation

“…The photocatalytic properties of ZnO may vary with particle size, morphology, and crystallinity of the materials. Modifications such as thermal treatment and/or doping the materials with other metals ions could enhance photocatalytic activity through limiting the recombination of electron-hole pairs and improving the absorption of light [41][42][43][44][45][46][47]. Under the current scenario of water pollution [48][49][50][51][52][53][54][55], there is need to prepare and utilized catalysts active under solar light to enhanced the cost effectiveness of catalytic process [56].…”

Physico-chemical and mechanical properties of novel electrospun polyurethane composite with enhanced blood compatibility

“…PU/Ra and PU/Ra/CeO 2 patch materials displayed a haemolytic index of 1.67% and 1.83%, respectively, whereas PU showed 2.83%, respectively, as indicated in Figure 7(c). The developed PU/Ra and PU/Ra/ CeO 2 patch materials behave as a non-haemolytic according to ASTMF756-00(2000) because of their index value less than 2% (Manikandan et al, 2018;Jaganathan et al, 2018). As mentioned, the most important characteristic for material in cardiac applications is it should present anti-thrombogenic surface and the developed PU/Ra and PU/Ra/CeO 2 patch materials exerted this behaviour in comparison with polyurethane suggesting its feasibility.…”

“…The CH band was observed at 2,920 cm À1 and 2,852 cm À1 and their vibration was seen at 1,414 cm À1 . The C = O was seen as twin peaks at 1,702 cm À1 and 1,730 cm À1 and the other peaks at 1,221 cm À1 , 1,105 cm À1 and 770 cm À1 represents the CO attributed to the alcohol group (Manikandan et al, 2018;Jaganathan et al, 2018). In the spectra of PU/Ra and PU/Ra/CeO 2 patch materials, no new peaks were noted but the intensity was increased with the addition of radish and cerium oxide.…”

“…Coagulation assays such as APTT, PT and haemolysis were done to evaluate the anti-thrombogenic nature of PU, PU/Ra and PU/Ra/CeO 2 cardiac patch material. The procedure for each analysis was followed from previously published works (Manikandan et al, 2018;Jaganathan et al, 2018).…”

Enhancing structural strength and improving cell survival through Polycaprolactone/(gelatin/hydroxyapatite) Core‐Shell nanofibers for tissue engineering

“…Also, scaffolds should have an interconnected pore structure to provide excellent transmittance of nutrients, oxygen, growth factors, and waste materials, thus, ensuring proper tissue growth and stem cell differentiation. Besides, the mechanical properties of a bone scaffold should be close to the natural bone 6–9 . Considering the above‐mentioned requirements, several materials with different fabrication methods have been suggested for bone scaffolds including, the development of hydroxyapatite/polyurethane (HA/PU) porous scaffolds via in‐situ polymerization, 10 fabrication of starch‐hydroxyapatite composite bone scaffold utilizing a slurry extrusion‐based solid freeform fabricator, 11 preparing porous hydroxyapatite (HA) scaffolds for bone tissue engineering using 3D gel printing, 12 etc.…”