Morphological, thermal and bioactivity evaluation of electrospun PCL/β-TCP fibers for tissue regeneration

Abstract

Electrospinning is a simple and low-cost way to fabricate fibers. Among the various polymers used in electrospinning, polycaprolactone (PCL) stands out due to its excellent biodegradability and biocompatibility. However, PCL has some limitations such as low bioactivity, hydrophobic surface, and long in vivo degradation. Calcium phosphate ceramics have been recognized as an attractive biomaterial. They are bioactive and osteoinductive, and some are even quite biodegradable. Different contents of particles of beta-tricalcium phosphate (β-TCP) were incorporated in polymer matrix to form fibers of PCL/β-TCP composites by electrospinning for possible application in tissue regeneration. The presence of β-TCP particles promoted some changes in the thermal properties of the fibers. The immersion of PCL/β-TCP 8 wt-% fibers in simulated body fluid (SBF) caused the formation of a denser and homogeneous apatite layer on its surface.

Poly(δ-valerolactone)/Poly(ethylene-co-vinylalcohol)/β-Tricalcium Phosphate Composite as Scaffolds: Preparation, Properties, and In Vitro Amoxicillin Release

“…Beta-tricalcium phosphate (β-TCP) is one of the most commonly used CaPs and has been shown to possess remarkable biocompatibility, osteoconductivity, bioresorbability, and direct bonding to bone experimentally [ 35 ] and clinically [ 36 , 37 ]. Moreover, it has been recently integrated with several polymers improving their characteristics as bone scaffolds [ 38 , 39 , 40 ].…”

“…Biological properties such as cell viability and proliferation were assessed using Alamar blue cell viability assay, and antibacterial activity was assessed using an inhibition test zone. To use these prepared hybrid materials as scaffolds releasing antibiotics, drug carrier systems containing PEVAL/PDVAL and PEVAL/PDVAL/β-TCP loaded with amoxicillin were chosen as the model prepared by the solvent casting route and a comparative in vitro study was carried out on this drug released in a medium of pH 7.4 [ 38 , 47 ].…”

Effect of kaolin waste annealing on the structural and thermal behavior of poly(ε−caprolactone)

“…Table 3 presents the neat PCL and the composites melting parameters, crystallization and the degree of crystallinity. The crystalline melting temperature (T m ) of PCL was approximately 59.9 literature [46,47]. The composites PCL/KW and PCL/HTKW, regardless of the filler content, did not significantly change the Tm compared to neat PCL, there was only a maintenance of the values.…”

Polycaprolactone usage in additive manufacturing strategies for tissue engineering applications: A review

“…Aside from the use of pure PCL or its blends, inorganic additives have been incorporated into the filaments to improve bioactivity. For example, bioactive glasses and calcium phosphates, such as HA and β‐tricalcium phosphate, have been extensively applied as bioactive fillers in bone tissue engineering because of their similarity to inorganic bone composition, which imparts good bioactivity, osteoconductivity, and osteoinductivity 118,141–143 . Other additives have also had an influence on the differentiation of mesenchymal stem cells and cell proliferation, such as specific angiogenic growth factors, 144,145 peptides, 146 and some inorganic oxides 147,148 .…”

“…For example, bioactive glasses and calcium phosphates, such as HA and β-tricalcium phosphate, have been extensively applied as bioactive fillers in bone tissue engineering because of their similarity to inorganic bone composition, which imparts good bioactivity, osteoconductivity, and osteoinductivity. 118,[141][142][143] Other additives have also had an influence on the differentiation of mesenchymal stem cells and cell proliferation, such as specific angiogenic growth factors, 144,145 peptides, 146 and some inorganic oxides. 147,148 Unfortunately, the high temperatures involved during the fabrication of molten polymers may limit the direct incorporation of biological factors or natural bioactive polymers.…”