Morphological substrate and pathogenetic mechanisms of pelvic pain syndrome in endometriosis. Part II. Peripheral nerve tissue remodeling in the foci of endometriosis

Kogan, E. A.; Ovakimyan, A. S.; Парамонова, Н. Б.; Файзуллина, Н. М.; Kazachenko, I F; Adamyan, LV

doi:10.17116/patol201678320-25

Cited by 9 publications

(5 citation statements)

References 10 publications

(16 reference statements)

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“…As an important member of the NT family, BDNF has a strong effect on the growth, differentiation and survival of nerve fibres [ 32 ] and promotes visceral pain and high sensitivity [ 33 ]. One study found that there were no nerve cells in endometriotic lesions; however, BDNF and NGF could promote the generation of nerve tissue in endometriotic lesions [ 34 ], and the expression levels of BDNF and NGF were correlated with the degree of pain in endometriosis patients [ 35 ]. However, another study showed that the expression levels of BDNF and NGF were not significantly correlated with the degree of pain [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea

Wang

Duan

et al. 2022

J Ovarian Res

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Background Brain-derived neurotrophic factor (BDNF) is a known regulator of the development and maintenance of chronic pain in various chronic disorders. Together with its high-affinity tyrosine kinase type B (TrKB) receptor, BDNF is extensively expressed in the mammalian female reproductive system. However, BDNF and TrKB expression in different stages of endometriosis and the relationship between the expression of each in ectopic lesions and endometriosis pain remain unclear. Methods Sixty-two women who underwent laparoscopic surgery were enrolled in this study: forty-six diagnosed with ovarian endometrioma (study group) and sixteen diagnosed with ovarian benign tumours (control group). Samples from eutopic endometrium and ovarian endometriotic lesions were obtained at laparoscopic surgery. BDNF and TrKB messenger RNA (mRNA) and proteins levels in the eutopic and ectopic endometrium of both groups were measured by real-time PCR and immunohistochemical staining, respectively. Before the surgery the visual analogue scale (VAS) was used to measure dysmenorrhoea. Results BDNF and TrKB expression levels were higher in ovarian endometriotic lesions than in eutopic endometrium and normal endometrium (P < 0.05), and there was no cyclical change. Furthermore, their expression levels were higher in eutopic endometrium than in normal endometrium (P < 0.05), and BDNF and TrKB levels were higher in stage IV ovarian endometriotic lesions than in stage II and III lesions (P < 0.05), with their expression being non-significantly higher in stage III than in stage II (P > 0.05). Additionally, correlation coefficients for the association analysis between the mRNA expression of BDNF or TrKB in eutopic endometrium and the dysmenorrhoea VAS score were r = 0.52 and r = 0.56 for BDNF and TrKB, respectively (P < 0.05). The correlation coefficients for the associations between BDNF and TrKB in both the eutopic and ectopic endometrium were r = 0.82 and r = 0.66, respectively (P < 0.05). Conclusions BDNF and TrKB are closely related to dysmenorrhoea caused by endometriosis and may be important in the pathobiology or pathophysiology of endometriosis.

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Section: Discussionmentioning

confidence: 99%

BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea

Wang

Duan

et al. 2022

J Ovarian Res

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“…Е. Коган и соавт. [23] получили результаты, демонстрирующие различия в экспрессии продукта гена протеина 9.5 (Protein gene product, PGP9.5), нейрофиламентов NF (Nerve factor), NGF (Nerve growth factor) и его рецептора р75 (NGFRp75) в гетеротопиях и прилегающей ткани при болевой и безболевой формах эндометриоза. При этом уровни экспрессии не зависят от локализации очагов эндометриоза.…”

Section: механизмы развития нейропатической боли при эндометриозеunclassified

“…Выявленные молекулярные особенности показывают возможность ремоделирования нервных волокон и нервных окончаний в гетеротопиях, а PGP9.5, NGF и NGFRp75 отвечают за формирование de novo нервных волокон и развитие болевого синдрома у пациенток с НГЭ. Что интересно, иммуногистохимический фенотип очагов эндометриоза не зависит от их расположения, а подтверждает наличие или отсутствие болевого синдрома [23]. Помимо этого, исследователи сделали предположение, что эутопический эндометрий у больных эндометриозом имеет свои особенности в сравнении с таковым у здоровых женщин [23].…”

Section: механизмы развития нейропатической боли при эндометриозеunclassified

“…Что интересно, иммуногистохимический фенотип очагов эндометриоза не зависит от их расположения, а подтверждает наличие или отсутствие болевого синдрома [23]. Помимо этого, исследователи сделали предположение, что эутопический эндометрий у больных эндометриозом имеет свои особенности в сравнении с таковым у здоровых женщин [23]. Это выражается наличием изменений в его структуре, пролиферативной активности, концентрации молекул адгезии, цитокинов, факторов роста, экспрессии различных генов.…”

Section: механизмы развития нейропатической боли при эндометриозеunclassified

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Molecular Mechanisms of Formation of Chronic Pelvic Pain Syndrome in Patients With External Genital Endometriosis: Markers and Targets for Diagnosis and Therapy (Review)

et al. 2018

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This article systematizes the results of studies on the pathogenetic mechanisms of CPPS formation in patients with EGE. Pain is one of the severe clinical manifestations and complications of endometriosis. To ease the pain in patients with EGE is complex but urgent task. Long diagnostic search (mean period 5−8 years) leads to the formation of a persistent Autonomous pain syndrome associated with relapses of pain even after a com-prehensive treatment of patients (surgical and/or long-term hormonal). Patients with endometriosis suffer from mixed pain including neuropathic and nociceptive components which is proved by the example of expression in ectopic foci of specific biomarkers. Therefore, the question of early non-invasive diagnosis of endometriosis is very vital and can be solved by the development of a diagnostic panel consisting of biomarkers expressed by ectopic foci at the initial stage of the disease.

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“…В целом снижение овариального резерва у пациенток с ЭКЯ подтверждено эхографическими, гистологическими, а также биохимическими критериями. При наличии эндометриоидной кисты в одном или обоих яичниках авторы отмечают уменьшение количества фолликулов с развитием атрезии, снижение антимюллерова гормона, ингибина-β, кроме того, выявлены изменения во внутрифолликулярной среде и в гранулезных клетках, в том числе уменьшение экспрессии ароматазы p450 и повышение уровня внутриклеточных свободных радикалов, дисбаланс в системе интерлейкинов [6,7].…”

Section: Introductionunclassified

Indicators of Ovarial Reserve, Pro- And Antioxidant System, Cytokine Status of Peripheral Blood and Peritoneal Liquid in Patients With Endometrioid Ovarian Cysts

Sokolova

Куценко

Кравцова

et al. 2019

Kuban. nauсh. med. vestnik

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The aimof this work was to identify the characteristics of the cytokine status and state of the pro- and antioxidant systems in patients of late reproductive age with endometrioid cysts and determine their role in changing the ovarian reserve.Materials and methods.A total of 89 patients with endometrioid ovarian cysts (EOC) were examined. The control group consisted of 35 healthy patients admitted for surgical sterilisation. Peripheral blood was collected before surgery, while the peritoneal fluid collection was performed intraoperatively. In peripheral blood and peritoneal fluid, the level of cytokines was determined. The calculation of the anti-inflammatory index was performed, along with the evaluation of the content of lipid peroxidation products and the antioxidant activity. The analysis of the ovarian reserve parameters was conducted.Results.In patients of late reproductive age suffering from EOC, a decrease in the ovarian reserve is observed under the preserved hormonal background. The presence of EOC is accompanied by the activation of lipid peroxidation, both at the systemic and local levels, under a pronounced inhibition of the antioxidant defence link. At the systemic and local levels, patients with EOC experience an imbalance in the cytokine system with a significant activation of the pro-inflammatory component.Conclusion.The disruption of oxidative homeostasis and activation of immune inflammation, detected in patients of late reproductive age with EOC, may lead to the damage of the structural cell components of the functional ovarian tissue, thereby reducing the ovarian reserve.Conflict of interest: the authors declare no conflict of interest.

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Morphological substrate and pathogenetic mechanisms of pelvic pain syndrome in endometriosis. Part II. Peripheral nerve tissue remodeling in the foci of endometriosis

Cited by 9 publications

References 10 publications

BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea

BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea

Molecular Mechanisms of Formation of Chronic Pelvic Pain Syndrome in Patients With External Genital Endometriosis: Markers and Targets for Diagnosis and Therapy (Review)

Indicators of Ovarial Reserve, Pro- And Antioxidant System, Cytokine Status of Peripheral Blood and Peritoneal Liquid in Patients With Endometrioid Ovarian Cysts

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