Morphological Study of Dressing Materials of Hemostatic Ac-Tivity in Experimental Animals

Abstract

Subject. In recent years, scientific research has been carried out to create new means for stopping bleeding, developed on the basis of hybrid organic-inorganic materials that contrib-ute to ensuring effective stopping of bleeding, regardless of blood clotting factors.
 The purpose of the study. To conduct a morphological study in experimental conditions on animals for a comparative assessment of the hemostatic effect of dressings coated with aluminum dioxide and iron nanoparticles.
 Methodology. To assess the hemostatic effect, an experimental study was conducted in the morphological laboratory of the Central Research Institute of State Medical University named after Abuali Ibni Sino on male white rats of the Vistar breed, weighing from 202 to 395, divided into 3 groups: 1st (control) – a bleeding wound was observed before its sponta-neous stop; 2nd group – nanostructured Aloobene was used; 3rd – a bleeding wound was treat-ed nanostructured Fe2O3. When setting up the experiment, the following main indicators of bleeding were determined: the time of stopping bleeding and the volume of blood loss.
 Results. When using nanostructured Aloobene, elements of necrosis of the epidermis and dermis were noted – scab; fragments of destroyed hair follicles, hair, sebaceous and sweat glands in the scab; stagnant full-blooded vessels; inflammatory cellular infiltrates. In the der-mis and hypoderma, fullness and stagnation in the vessels, pronounced edema and destruction of fibrous-fibrous tissue were determined. Diffuse leukocyte infiltrates, foci of hemorrhage and necrosis were detected in places in the tissues. The inflammatory infiltrate forms clear contours of the de-marking line.
 Conclusions. The obtained results of a morphological study in experimental animals in-dicate a greater effectiveness of the blood-reducing effect when using aluminum oxide com-pared with iron oxide, the absence of toxic and teratogenic effects.