Morphological spectrum of peripheral nerve sheath tumors: An insight into World Health Organization 2013 classification

Abstract

Introduction:Peripheral nerve sheath tumors (PNSTs) are neuroectodermal in origin. Now these tumors are classified under World Health Organization (WHO) classification of tumors of soft tissue and bone 2013.Objective:To study the morphological spectrum of PNST and to study the secondary degenerative changes associated with it.Materials and Methods:This study was conducted from January 2010 to June 2015. The gross details of tumor and patient's demographic profiles were reviewed. The hematoxylin and eosin stained slides were reassessed and the lesions were categorized and classified as per the WHO 2013 classification. The tumors were also assessed for secondary degenerative changes.Results:Our study comprised 143 cases of PNST. Age of the patients ranged from 5 to 75 years. 21–30 years is the most common age of occurrence with head and neck being the most common site. The PNSTs observed in the present study were neurofibroma (NF) (61.5%), schwannoma (36%), malignant PNST (2%), and granular cell tumor (0.5%). Nearly 10% of NF fulfilled the criteria for neurofibromatosis 1 (NF1). Rare tumors such as plexiform schwannoma and granular cell tumor were also observed. Malignant tumors were larger in dimension than benign. Myxoid, cystic, and hyaline changes were commonly associated with benign tumors while necrosis, hemorrhage, and mitotic activity were seen with malignant tumors.Conclusion:This series highlights the pathological variants of PNST along with their morphological changes and NF1 association. It is essential to be familiar with all these variants of PNST for accurate diagnosis as they have varied biological behavior.

Demographics, management and treatment outcomes of benign and malignant retroperitoneal tumors in Japan

“…Benign tumors were more frequently found in the younger population, and 64.7% of our patients aged younger than 30 years had benign tumors. LS was the most common histological type, and comprised 57.7% of intermediate and malignant tumors, similar to that reported in other studies . Leiomyosarcoma comprised 10.4% of intermediate and malignant tumors, and was slightly less common compared with that reported in other studies, where leiomyosarcomas comprised 16–40% of retroperitoneal sarcomas …”

“…Tumor histology, grade, size and treatment are strong determinants of local recurrence and survival in patients with retroperitoneal tumors . Patients with malignant tumors had significantly worse overall, disease‐specific and recurrence‐free survival rates than those with benign and intermediate tumors.…”

“…It is anticipated that complete resection, including resection of contiguous organs when necessary, can improve oncological outcome. Although the superiority of R0 to R1 in oncological outcome remains to be determined, most studies showed that a grossly positive margin (R2) was a strong indicator of unfavorable clinical outcomes, in terms of recurrence and survival, compared with the macroscopic clearance of resection margin (R0/R1) . These studies analyzed the prognostic importance of margin status without considering the malignant potential of tumors.…”

Peri̇feri̇k Si̇ni̇r Kilifi Tümörleri̇: 76 Olgunun Kli̇ni̇kopatoloji̇k Değerlendi̇rmesi̇

“…2,[4][5][6] Approximately half of the NF cases were located outside the head and neck (Table 3) be resected with no minimal or no postoperative neurological deficits. 1,3,4,7 In our study, the mean age was 42. 3 in accordance with the literature.…”

“…As gross, the cross section is bright fl esh-white in colour. 3,4 Although Schwannomas constitute the majority of PNSTs in various studies, the most common histological type is NF. 2,[4][5][6] Approximately half of the NF cases were located outside the head and neck (Table 3) be resected with no minimal or no postoperative neurological deficits.…”