Morphological properties and residual strain along the small intestine in rats

Zhao, Jingbo; Sha, Hong; Zhuang, Fengyuan; Gregersen, Hans

doi:10.3748/wjg.v8.i2.312

Cited by 25 publications

(31 citation statements)

References 31 publications

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“…The reason could be due to the axial differences in morphology and passive biomechanical properties in the small intestine. Previous studies have shown the different passive biomechanical properties among the duodenal, jejunal and ileal segments of the intestine [17,21,27,28]. The differences in biomechanical properties are probably associated with the specialised functions of the proximal and distal segments of the small intestine.…”

Section: Discussionmentioning

confidence: 95%

“…The experimental procedures are similar as those reported by us before [16,17,18,19,20,21]. Briefly, after 4 days, 1, 2 and 4 weeks, respectively, the animals were anaesthetised with sodium pentobarbital (50 mg/kg, ip).…”

Section: Methodsmentioning

confidence: 99%

“…One study showed that diabetes altered the tension-strain relation of the small intestine in a way consistent with stiffening of the intestinal wall [10]. In recent years, the passive biomechanical properties of the normal and diseased intestinal wall have been studied extensively in humans and animals [11,12,13,14,15,16,17,18,19]. We consider the zero-stress state, residual strain and stressstrain relationship of the intestinal wall as the relevant quantitative remodelling parameters because they are measures of the non-uniformity of growth or resorption in different parts of the intestinal wall.…”

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confidence: 99%

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Biomechanical and morphometric intestinal remodelling during experimental diabetes in rats

2003

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Aims/hypothesis. Morphometric and passive biomechanical properties were studied in the duodenum, jejunum and ileum in 10 non-diabetic and 40 streptozotocin-induced diabetic rats. Methods. The diabetic rats were divided into groups living 4 days, 1, 2, and 4 weeks after diabetes was induced (n=10 for each groups). The mechanical test was done as a ramp distension experiment. The intestinal diameter and length were obtained from digitised images of the intestinal segments at pre-selected pressures and at no-load and zero-stress states. Circumferential and longitudinal stresses (force per area) and strains (deformation) were computed from the length, diameter and pressure data and from the zero-stress state geometry. Results. The blood glucose concentration increased four-to fivefold in the diabetic rats. Streptozotocin-induced diabetes generated pronounced increase in the weight per centimetre length, wall thickness and wall cross-sectional area in all intestinal segments during diabetes (p<0.05). Histological analysis showed that the thickness of the intestinal layers was increased in all segments during diabetes (p<0.05). In the duodenum the opening angle did not change in the first 2 weeks and decreased after 4 weeks (p<0.05). In the jejunum and ileum the opening angle increased after 1 week in the diabetic group. The residual strain showed the same pattern as the opening angle. Furthermore, it was found that the circumferential and longitudinal stiffness of the intestinal wall increased with the duration of diabetes (p<0.05 and p<0.01). Conclusion/interpretation. Morphological and biomechanical remodelling of the small intestine occurred during the development of diabetes. [Diabetologia (2003[Diabetologia ( ) 46:1688[Diabetologia ( -1697

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Section: Discussionmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Biomechanical and morphometric intestinal remodelling during experimental diabetes in rats

2003

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“…This strain varies in a complex fashion between layers of the gut, as well as along the gradient from duodenum to colon [2, 3]. Mucosal compressive residual strain in excised rat small intestine in organ baths has been estimated at 25–40% [2].…”

Section: Physical Forces Acting Upon the Intestinal Mucosa During Normentioning

confidence: 99%

Paradigms for Mechanical Signal Transduction in the Intestinal Epithelium

Basson¹

2003

Digestion

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Diverse physical forces including deformation or strain, pressure, and shear stress affect the intestinal mucosa during normal function, and mucosal biology is altered in pathological states in which these forces alter. Taken together with evidence in other tissues and cell types that physical forces can affect cell biology, this has led to the hypothesis that repetitively applied physical forces can initiate intracellular signals that alter intestinal epithelial proliferation and phenotype. This review outlines the nature of such forces and summarizes in vivo and in vitro evidence in support of the paradigm that repetitive force is trophic for the intestinal mucosa via a complex cascade of intracellular signals.

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“…Vaishnav and Vossoughi [20] and Fung [21] independently reported respectively that the no-load state of a blood vessel was not the zero stress state. Recently, residual strains were demonstrated in the esophagus, small intestine, and large intestine [14][15][16][22][23][24][25][26][27][28] and were found to be closely related to the growth and remodeling [24][25][26][27][28][29][30] . Hence the analysis of stress and strain begins with identification of the zero stress state.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical properties of ileum after systemic treatment with epithelial growth factor

Yang

Zhao²,

Zeng³

et al. 2003

WJG

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AIM: Systemic treatment with epidermal growth factor (EGF) leads to growth of all parts of the small intestine in normal functioning rats. In this study, we investigated the effect of this growth process on morphometric and biomechanical parameters of ileum. METHODS:Rats were treated with EGF (150 µg·kg -1 day -1 ) or placebo via osmotic minipumps for 2, 4, 7, and 14 days. A segment of ileum was removed. The morphology at noload state and zero-stress state was measured and passive biomechanical properties were assessed using a biaxial test machine (combined inflation and axial stretching). RESULTS:The ileum weight increased after EGF administration. After 4 days' EGF treatment, the wall thickness was increased. Significantly smaller inner perimeters were seen in 4 day and 7 day EGF treatment groups. The opening angle and residual strain began to increase after 7 days' EGF treatment. Wall stiffness, evaluated from the stress-strain curves, showed a continuous decrease in circumferential direction during the first 7 days' EGF treatment. The longitudinal stiffness increased during the first 7 days. The stress-strain curves for both circumferential and longitudinal direction tended to shift back to normal 14 days after starting EGF administration.CONCLUSION: EGF can cause significant changes both in the morphology and in the passive mechanical properties of the rat ileum.Yang J, Zhao JB, Zeng YJ, Gregersen H. Biomechanical properties of ileum after systemic treatment with epithelial growth factor.

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Morphological properties and residual strain along the small intestine in rats

Cited by 25 publications

References 31 publications

Biomechanical and morphometric intestinal remodelling during experimental diabetes in rats

Biomechanical and morphometric intestinal remodelling during experimental diabetes in rats

Paradigms for Mechanical Signal Transduction in the Intestinal Epithelium

Biomechanical properties of ileum after systemic treatment with epithelial growth factor

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