Morphological predictors of sleep apnoea severity

Wysocki, Jarosław; Krasny, Marta; Prus, Marzena

doi:10.5603/fm.a2015.0069

Cited by 5 publications

(10 citation statements)

References 15 publications

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“… 32 described the two divided segments of the E-tube, the muscles attached to the E-tube, and the seromucous glands under the epithelium, and discussed the possible mechanism of the opening and closure of the E-tube based on its musculature. Wysocki 33 elaborated the configurations and internal structures of the rat temporal bone, middle, and inner ear and measured the parameters of the external auditory, internal auditory meatus, auditory ossicles, tympanic cavity, and E-tube: most results were consistent with those of the present study. However, the fundamental purpose of this study was to perform E-tube angiography using an interventional method that can offer an optimal approach for further investigation of ETD treatment.…”

Section: Discussionsupporting

confidence: 88%

“…The diameter, overall length, and length of the nasopharyngeal opening of rat E-tubes have been reported in several previous studies. 32 , 33 , 34 However, these studies have not indicated the measurement methods for these parameters, and several of the data are shown as approximate values. In the present study, the anatomical parameters of the E-tube were precisely measured using ImageJ software.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The rat eustachian tube: Anatomical, histological, and radiological features

Wang

Bakheet

et al. 2023

Journal of Interventional Medicine

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

The rat eustachian tube: Anatomical, histological, and radiological features

Wang

Bakheet

et al. 2023

Journal of Interventional Medicine

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“…[35][36][37] A total of 39.2% of this study population had severe OSA, and mild and moderate OSA were 16.3% and 27.1% respectively (Table 3). Our study demonstrated that female patients with AHI > 15 showed no significant differences in the posterior airway space and soft palate length ( 24 In this study, we report that the male patients in AHI < 15 and AHI > 15 groups showed significant differences in the SPL. In contrast, the female patients showed no significant differences in SPL with increasing severity of OSA.…”

Section: Ta B L E 4 (Continued)mentioning

confidence: 55%

“…20 In addition, a study that evaluated the relationship between the facial morphological features and the increasing severity of OSA demonstrated a significant connection between neck circumference and AHI in male patients with OSA in the stepwise regression model. 24 It was also reported that neck circumference and BMI were important predictors of OSA. [25][26][27] Rogers et al reported a similar finding in a study that BMI or waist circumference could be the predictors associated with the risk of OSA in the Black population.…”

Section: Ta B L Ementioning

confidence: 96%

Gender differences in the upper airway, craniofacial morphological and polysomnographic parameters in patients with obstructive sleep apnoea

Udayakumar,

Jo,

Kim

et al. 2023

J of Oral Rehabilitation

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BackgroundObstructive sleep apnoea (OSA) is a common sleep disorder characterized by repetitive episodes of upper airway collapse during sleep associated with arousals with or without oxygen desaturation.ObjectiveThis study aims to assess and analyse the morphological and neurological factors associated with obstructive sleep apnoea using polysomnography study data and two‐dimensional cephalometric analysis of airway and skeletal parameters and their correlation in the patients with varying severities of obstructive sleep apnoea.MethodsThis study included 892 patients who underwent a complete work up, including a thorough history, clinical examination, standard polysomnography study and 2D cephalometric analysis to diagnose obstructive sleep apnoea. This study divided the participants into two groups based on the AHI score from the PSG study: AHI < 15 and AHI > 15 groups. The groups were further divided into male and female groups to study the prevalence of OSA. The analysis involved 13 cephalometric parameters: Seven linear and six angular measurements. The airway parameters measured in this study were minimum posterior airway space (PAS_min), hyoid bone to the mandibular plane (H_MNP) and soft palate length (SPL). All the subjects in this study underwent a standard overnight polysomnography study at the sleep centre in Samsung Medical Center.ResultsA total of 892 adult participants (M: F = 727:165, mean age: 50.6 ± 13.2 years and age range: 18–85 years). AHI >15 group was significantly older with higher BMI, NC and WC compared to the AHI < 15 groups in both male and female groups. There was statistical significance observed in N1, N3, AI, ODI, lowest saturation (%) and apnoea max length between the groups (p < .001). The arousal index (AI), especially the respiratory arousal index was considerably higher in the male group. There were significantly higher values in all the PSG parameters in the male group. In the airway parameters, hyoid bone position and soft palate length showed significant differences (p < .001), whereas the PAS did not show any differences (p = .225) between the AHI <15 and AHI >15 groups. The overall skeletal cephalometric parameters showed no significant differences between the groups, whereas the gonial angle and AB to mandibular plane angle showed significant differences in the female group (p = .028, p = .041 respectively).ConclusionThe partial correlation of cephalometric parameters with AHI showed a stronger correlation between the H_MNP and AHI in both men and women. The position of the hyoid bone and the soft palate length influences the progression of OSA, especially in male patients. This study found no direct association between the minimum PAS and varying severities of OSA in men and women. We speculate that more than the craniofacial morphological factors such as the sagittal and vertical position of the maxilla and the mandible, the position of the hyoid bone might be more responsible for the severity of OSA.

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“…This small parameter allows the microneedle to be inserted into the cochlea without fracture of the osseous spiral lamina, thus reducing modiolar injury. [ 29 ] The FM1‐43FX microneedles were prepared by codissolving PLGA copolymer and FM1‐43FX, a fixable fluorescent dye that behaves as a permanent blocker of the mechanotransducer channel, in DMSO (Figure 8D). The final concentration of the FM1‐43FX dye was 1% (w/w) of the PLGA.…”

Section: Resultsmentioning

confidence: 99%

Dexamethasone (DXM)‐Coated Poly(lactic‐co‐glycolic acid) (PLGA) Microneedles as an Improved Drug Delivery System for Intracochlear Biodegradable Devices

Pawley

Goncalves

Bas

et al. 2021

Advanced Therapeutics

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Uniform drug delivery techniques are challenging to develop for the inner ear due to the complexity of the cochlear anatomy. A promising solution is the use of biodegradable polymers because the continuous release of therapeutics without introducing toxic compounds is desirable. Using a microneedle approach lends the polymeric microneedle the capability to be placed inside of the scala tympani, releasing drugs overtime. Poly(lactic-co-glycolic acid) (PLGA) microneedles is prepared by dissolving dimethyl sulfoxide with either a) Rhodamine B, to study the drug release profile in vitro, b) FM1-43, to study the drug release profile in vivo, or c) dexamethasone (DXM), to protect hair cell (HC) loss in vivo. The Rhodamine B studies show that the dye begins release from the microneedles within 30 min. The ototoxicity assessment of the DXM-coated microneedles in vitro shows a significant reduction of HC losses when compared to control microneedles in an ototoxic environment. In vivo data show reduced hearing threshold for animals treated with DXM-infused microneedles, providing a proof of concept of the methodology developed. Drug-infused polymeric microneedles provide a promising method to deliver DXM to the inner ear over controlled periods of time protecting hair cells, thus minimizing hearing loss (HL).

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Morphological predictors of sleep apnoea severity

Abstract: (Folia Morphol 2016; 75, 1: 107-111)

Cited by 5 publications

References 15 publications

The rat eustachian tube: Anatomical, histological, and radiological features

The rat eustachian tube: Anatomical, histological, and radiological features

Gender differences in the upper airway, craniofacial morphological and polysomnographic parameters in patients with obstructive sleep apnoea

Dexamethasone (DXM)‐Coated Poly(lactic‐co‐glycolic acid) (PLGA) Microneedles as an Improved Drug Delivery System for Intracochlear Biodegradable Devices

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