Morphological Predictors and Molecular Markers of Progressing Postoperative Remodeling of Left Ventricle in Patients with Ischemic Cardiomyopathy

Шипулин, В. М.; Казаков, В. А.; Лежнев, А. А.; Козлов, Б. Н.; Бабокин, В. Е.; Gutor, Sergey; Suhodolo, Irina V.

doi:10.5772/25524

Cited by 2 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 It is well known that patients undergoing LV reconstruction are at high surgical and cardiac risk; therefore, the main treatment outcome of interest is still early mortality and subsequently long-term survival and quality of life in this group of patients. 2,3,5,10,11 For the first time, researchers began to search for morphological predictors of postoperative cardiac remodeling in patients with ICM more than 20 years ago, analyzing the course of the postoperative period and assessing the morphofunctional state of the LV myocardium according to intraoperative biopsy results. 12 As a possible predictor of cardiac dilatation, some authors tried to take the mean value of the diameter of CMCs of the LV.…”

Section: Discussionmentioning

confidence: 99%

Morphological and immunological markers of repeated heart remodeling after surgical reconstruction of the left ventricle in ischemic cardiomyopathy

Shipulin

Андреев

Belyaeva

et al. 2023

Asian Cardiovasc Thorac Ann

View full text Add to dashboard Cite

Introduction Effective treatment of patients with ischemic cardiomyopathy (ICM) is one of the most challenging issues in modern cardiac surgery. The aim of this study was to assess the state of cardiomyocytes and myocardial extracellular matrix, as well as to identify informative markers of an unfavorable prognosis for surgical treatment of ICM. Materials and methods We retrospectively reviewed patients who underwent surgical treatment of ICM between 2011 and 2018 at a single center. Patients were divided into groups depending on the presence of repeated left ventricle (LV) remodeling in one-year follow-up after surgical reconstruction of the LV in ICM patients. Results A total of 45 patients with ICM were reviewed. The mean age of the patients was 57.9 ± 7.8 years. According to the results of the study, the area of cardiomyocyte nuclei differed statistically significantly among the regions with varying degrees of impaired local contractility ( p = 0.042). According to the results of the pairwise comparison in dyskinetic areas of the myocardium, the area of cardiomyocyte nuclei was higher than in normokinetic areas ( p = 0.042). A moderate positive correlation was found between the LV ejection fraction measured in one-year follow-up period after surgery and the number of CD163-positive cells ( p = 0.012). Conclusion In the myocardium of patients with LV reverse remodeling in the long-term postoperative period, perivascular fibrosis occurs more frequently than in patients with progressive LV remodeling. The number of M2-anti-inflammatory macrophages prevails in the myocardium of the patients with reverse remodeling compared with patients with progressive remodeling.

show abstract

Section: Discussionmentioning

confidence: 99%

Morphological and immunological markers of repeated heart remodeling after surgical reconstruction of the left ventricle in ischemic cardiomyopathy

Shipulin

Андреев

Belyaeva

et al. 2023

Asian Cardiovasc Thorac Ann

View full text Add to dashboard Cite

show abstract

Thorny and fruitful path of Tomsk cardiac surgery and anesthesiology

Шипулин

2021

SMJ

View full text Add to dashboard Cite

Научно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наук, 634012, Российская Федерация, Томск, ул. Киевская, 111а АннотацияСтатья содержит краткий исторический очерк, посвященный развитию сердечно-сосудистой хирургии в Томске. Представлены основные достижения, клинические и научные направления в деятельности отделения сердечно-сосудистой хирургии Научно-исследовательского института кардиологии. Статья рассчитана на кардиологов, терапевтов, кардиохирургов, анестезиологов. Ключевые слова:сердечно-сосудистая хирургия, анестезиология и реанимация, нарушение ритма сердца, исторический очерк. Конфликт интересов:автор заявляет об отсутствии конфликта интересов. Прозрачность финансовой деятельности:автор не имеет финансовой заинтересованности в представленных материалах или методах.

show abstract

Morphological Predictors and Molecular Markers of Progressing Postoperative Remodeling of Left Ventricle in Patients with Ischemic Cardiomyopathy

Cited by 2 publications

References 30 publications

Morphological and immunological markers of repeated heart remodeling after surgical reconstruction of the left ventricle in ischemic cardiomyopathy

Morphological and immunological markers of repeated heart remodeling after surgical reconstruction of the left ventricle in ischemic cardiomyopathy

Thorny and fruitful path of Tomsk cardiac surgery and anesthesiology

Contact Info

Product

Resources

About