Morphological parameters of the heterogeneity of the substantia nigra in elderly men and women

Pollution with heavy metal salts is an important environmental problem today, having an adverse effect on public health. The endocrine system maintains homeostasis in the body. The antioxidant protection (GPX-1) of the pineal gland in mature rats was studied. Animals of the experimental group represented a model of microelementosis, achieved by adding a mixture of heavy metal salts for 90 days to drinking water: zinc (ZnSO4×7H2O) – 5 mg/l, copper (CuSO4×5H2O) – 1 mg/l, iron (FeSO4) – 10 mg/l, manganese (MnSO4×5H2O) – 0.1 mg/l, lead (Pb(NO3)2) – 0.1 mg/l, and chromium (K2Cr2O7) – 0.1 mg/l. Morphological, statistical and immunohistochemical (GPX-1) research methods were used. Long-term (90-days) intake of heavy metal salts mixture in the body of experimental animals brought about development of the general adaptation syndrome, the stage of chronic stress “subcompensation” in the pineal gland. Morphological rearrangements were of nonspecific polymorphic nature as severe hemodynamics disorder in the organ, impairment of vascular wall morphology, development of tissue hypoxia and oxidative stress, accompanied by processes of accelerated apoptosis in part of pinealocytes, by a significant decrease in glutathione peroxidase level in the organ and reactive astrogliosis as a response to the damaging agent’s action. Along with the negative changes in the pineal gland, a compensatory-adaptive processes with signs of functional stress also occurred. A sufficiently high degree of glutathione peroxidase activity in 39% of pinealocytes located perivascularly, active adaptive glial reaction and activation of synthetic processes in some pinealocytes were also observed.

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“…40, oc. 10), studying at least 30 fields of view (Salkov et al, 2015). In this case viable pinealocytes only were taken into account.…”

Section: Pineal Gland Extraction Technique and Histological Studiesmentioning

confidence: 99%

A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts

et al. 2022

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Immunohistochemical Characteristics of Neurons in the Substantia Nigra of the Human Brain

Коржевский

Grigor’ev

Sukhorukova

et al. 2018

Neurosci Behav Physi

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Immunohistochemical characteristics of the substantia nigra neurons of the human

Коржевский

Grigor’ev

Sukhorukova

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Morphological parameters of the heterogeneity of the substantia nigra in elderly men and women

Cited by 3 publications

References 8 publications

A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts

A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts

Immunohistochemical Characteristics of Neurons in the Substantia Nigra of the Human Brain

Immunohistochemical characteristics of the substantia nigra neurons of the human

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