Morphological parameters of ovarian masses and accuracy of the risk of malignancy index in diagnosing ovarian malignancy

Adilgereyeva, Akmaral S; Abdelazim, Ibrahim A.; Zhurabekova, Gulmira; El-Ghazaly, Tamer E

doi:10.5114/pm.2022.116402

Cited by 3 publications

(4 citation statements)

References 40 publications

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“…Adilgereyeva et al . found that the RMI-I at a cut-off value > 245.7 had 87.1% sensitivity and 100% specificity in diagnosing ovarian malignancy in menopausal women [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Accuracy of the risk of malignancy index-I in diagnosing ovarian malignancy in menopausal women

Radwan¹,

Taema²

2023

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Introduction To detect the accuracy of the risk of malignancy index-I (RMI-I) in diagnosing ovarian malignancy in menopausal women. Material and methods Eighty-two menopausal women with suspected ovarian masses (OMs) scheduled for surgery were included in this study. Blood samples were preoperatively collected from participants to measure the CA-125, followed by transvaginal sonography to evaluate the suspected OMs regarding the consistency, whether the OMs were unilateral or bilateral, unilocular or multilocular, and for extra-ovarian metastasis. The preoperative RMIs were compared to the postoperative histology of the excised OMs to detect the accuracy of RMI-I at a cut-off value of 200 in diagnosing ovarian malignancy. The receiver operating characteristic curve was also used to detect the cut-off value of RMI-I with the highest sensitivity and specificity in diagnosing ovarian malignancy in menopausal women. Results The incidence of benign and malignant OMs in the studied menopausal women was 59.8% and 40.2%, respectively. The risk of malignancy index-I at a cut-off value 200 in this study had 75.8% sensitivity, 91.8% specificity, 86.2% positive predictive value (PPV), and 84.9% negative predictive value (NPV) in diagnosing ovarian malignancy in menopausal women. The receiver operating characteristic curve showed that the RMI-I at a cut-off value of > 241.5 had 96% sensitivity and 94.74% specificity in diagnosing ovarian malignancy in menopausal women (AUC 0.98, 95% CI: 0.92–0.99, p < 0.001). Conclusions The risk of malignancy index I at a cut-off value of 200 had 75.8% sensitivity, 91.8% specificity, 86.2% PPV, and 84.9% NPV in diagnosing ovarian malignancy in menopausal women. The receiver operating characteristic curve showed that the RMI-I at a cut-off value > 241.5 had 96% sensitivity and 94.74% specificity in diagnosing ovarian malignancy in menopausal women.

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“…Adilgereyeva et al . found that the RMI-I at a cut-off value > 245.7 had 87.1% sensitivity and 100% specificity in diagnosing ovarian malignancy in menopausal women [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Yamamoto et al found the RMI-I at a cut-off value of 450 had 75% sensitivity and 91% specificity in diagnosing ovarian malignancy [32]. Adilgereyeva et al found that the RMI-I at a cut-off value > 245.7 had 87.1% sensitivity and 100% specificity in diagnosing ovarian malignancy in menopausal women [33].…”

Section: Risk Of Malignancy Index-imentioning

confidence: 99%

Accuracy of the risk of malignancy index-I in diagnosing ovarian malignancy in menopausal women

Radwan¹,

Taema²

2023

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“…The BMI was calculated from the studied adolescents’ body weight and their height (kg/m 2 ) [ 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

Vitamin D and vitamin D receptor polymorphism in Asian adolescents with primary dysmenorrhea

Donayeva,

Amanzholkyzy,

Nurgaliyeva

et al. 2023

BMC Women's Health

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Background The expression of vitamin D receptor in the normal endometrium and ovaries supports the role of vitamin D in local immunity and inflammatory cytokines regulation. Objective This study aimed to detect the relation between serum 25(OH)D and primary dysmenorrhea in Asian Adolescents. Methods Two hundred and five (205) adolescents complaining of primary dysmenorrhea (study group) were compared in this prospective study to matched controls (210 controls) after informed consent following the Helsinki Declaration. After thorough evaluation, including a thorough history and pelvic ultrasound examination, blood samples were collected from the studied adolescents to measure serum 25(OH)D and for vitamin D receptor TaqI (rs731236) genotyping. The studied adolescents’ data were analyzed using the Pearson’s correlation to detect the relation between serum 25(OH)D and primary dysmenorrhea (primary outcome). The secondary outcome measures the odds of primary dysmenorrhea in Asian adolescents with vitamin D receptor TaqI (rs731236) polymorphism. Results The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls (16.17 ± 7.36 versus 17.65 ± 6.36 ng/ml, respectively), (P = 0.01). The correlation analysis showed a significant negative correlation between the serum 25(OH)D and visual analogue scale of dysmenorrhea (r = -0.9003, P < 0.0001). The studied-dysmenorrhea cases with vitamin D receptor T/t and t/t genotypes had significantly lower serum 25(OH)D (16.7 ± 8.05 and 14.4 ± 4.1 ng/ml, respectively) compared to controls (18.97 ± 6.7 and 21.4 ± 2.45 ng/ml, respectively), (P = 0.02 and 0.004, respectively). The VDR T/t and t/t polymorphisms significantly increase the odds of primary dysmenorrhea (OR 1367.2, P < 0.0001 and OR 106.2, P = 0.001, respectively). Conclusion The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls. The studied-dysmenorrhea cases with VDR T/t and t/t TaqI genotypes had significantly lower serum 25(OH)D compared to controls. The VDR T/t and t/t polymorphisms significantly increase the odds of primary dysmenorrhea.

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“…Exclusion criteria include adolescents < 12 years-old or >18 years-old, underweight (BMI ≤ 18.5), overweight (BMI 25–29.9) or obese (BMI > 30) [ 15 , 17 ], with irregular menstrual cycles, known medical disorders (i.e., diabetes, or hypertension), known endocrine disorders (i.e., thyroid, or hyperprolactinemia), and received exogenous hormones within the last year.…”

Section: Methodsmentioning

confidence: 99%

Relation between vitamin D and adolescents’ serum prolactin

Amanzholkyzy,

Donayeva,

Kulzhanova

et al. 2023

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Introduction To detect whether there is a relation between vitamin D (Vit. D) and adolescents’ serum prolactin (PRL) or not. Material and methods Hundred and seventy-six adolescent girls were recruited for the current study, which was conducted in West Kazakhstan (Aktobe) over two years. After thorough evaluation, blood samples were taken from adolescents to measure thyroid stimulating hormone (TSH), free thyroxine (T4), PRL, glycosylated hemoglobin and 25(OH)D. The studied adolescents were classified into study group [25(OH)D deficient] and controls [normal 25(OH)D]. The acquired adolescents’ variables were analyzed using the Student t -test and Pearson’s correlation. Results The serum TSH and PRL were statistically higher in the study group than normal controls (3.73 ±1.45 mIU/ml and 47.5 ±7.6 ng/ml vs. 2.67 ±1.0 and 10.8 ±5.1, respectively), ( p = 0.0003 and p = 0.0001, respectively). The free T4 was statistically lower in the study group than normal controls (1.4 ±0.6 ng/ml vs. 1.5 ±0.4), ( p = 0.0001). Strong negative associations between the serum PRL and 25(OH)D [ r = –0.803 ( p < 0.00001)], and between the serum PRL and free T4 [ r = –0.6959 ( p < 0.00001)] were detected in this study. Additionally, there was a strong positive association between the serum PRL and TSH [ r = 0.8137 ( p < 0.00001)]. Conclusions A strong negative association between the serum PRL and 25(OH)D and a strong positive association between the serum PRL and TSH were detected in this study. This study recommends further studies to confirm the relation between Vit. D and PRL and screening Vit. D deficient adolescents for PRL and thyroid disorders.

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Morphological parameters of ovarian masses and accuracy of the risk of malignancy index in diagnosing ovarian malignancy

Cited by 3 publications

References 40 publications

Accuracy of the risk of malignancy index-I in diagnosing ovarian malignancy in menopausal women

Accuracy of the risk of malignancy index-I in diagnosing ovarian malignancy in menopausal women

Vitamin D and vitamin D receptor polymorphism in Asian adolescents with primary dysmenorrhea

Relation between vitamin D and adolescents’ serum prolactin

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