Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis

Ziccardi, Lucia; Barbano, Lucilla; Boffa, Laura; Albanese, Maria; Grzybowski, Andrzej; Centonze, Diego; Parisi, Vincenzo

doi:10.3389/fneur.2020.00858

Cited by 6 publications

(14 citation statements)

References 38 publications

(84 reference statements)

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“…In a similar cohort of MS-noON patients, we [ 23 ] recently observed an absence of WR and IR MVs reduction, and, differently from Saidha et al [ 20 ], we detected that OR MV and MT values were not significantly different from Controls. Taking in account this evidence, our mfERG results may indicate that in MS-noON patients an absence of outer macular layers’ morphological involvement together with an absence of O-MR dysfunction can be hypothesized.…”

Section: Discussioncontrasting

confidence: 77%

“…As for the MS-noON Group, in a similar cohort of MS-ON-G patients, we recently observed significantly reduced WR and IR MVs and MTs, with OR values similar to Controls; an extensive explanation of these findings was previously discussed [ 23 ]. Hence, the presence of mfERG values similar to Controls in this Group, and also considering the previously observed [ 23 ] absence of OR morphological impairment, led us to believe that in MS patients with previous history of ON and good recovery of BCVA there are structural changes involving IR but not OR, with also normal O-MR function.…”

Section: Discussionmentioning

confidence: 52%

“…In addition, since a morphological impairment of macular OR has been described in MS-ON patients [ 20 ] and in our recent work was confirmed to be detectable exclusively in those MS-ON patients with poor recovery of BCVA [ 23 ], we also evaluated in MS-ON-P patients whether a possible preganglionic macular dysfunction could be associated or not to structural OR changes for corresponding retinal areas.…”

Section: Discussionmentioning

confidence: 99%

“…In all MS-ON-P patients, the macular morphology was evaluated by the RTVue-100 Sd-OCT device, following our recently published method [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…In addition, a morphological involvement of the outer macular layers in MS patients with history of ON was described [ 20 ], but with no clear information whether the morphological changes were related or not to the recovery of BCVA after ON. In order to evaluate the macular morphological changes in MS patients with recovery or not of BCVA after an ON, we recently published a work [ 23 ] in which a morphological involvement of the outer macular layers was detectable exclusively in those MS patients with poor recovery of BCVA after ON, whereas when a good recovery after ON was reached, the morphology the outer macular layers was not statistically different from those of Controls. Thus, we believed that, in MS patients with poor recovery of BCVA, it could be interesting to evaluate whether a possible preganglionic macular dysfunction could be associated or not to the above-mentioned morphological changes.…”

Section: Introductionmentioning

confidence: 99%

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Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis

Ziccardi

Barbano

Boffa

et al. 2020

JCM

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The involvement of macular preganglionic elements’ function, during the neurodegenerative process of multiple sclerosis (MS), is controversial. In this case-control observational and retrospective study, we assessed multifocal electroretinogram (mfERG) responses from 41 healthy Controls, 41 relapsing-remitting MS patients without optic neuritis (ON) (MS-noON Group) and 47 MS patients with ON: 27 with full recovery of high-contrast best corrected visual acuity (BCVA) (MS-ON-G Group) and 20 with poor recovery (between 0.2 and 1 LogMAR) of BCVA, (MS-ON-P Group). In the latter Group, Sd-OCT macular volumes and thicknesses of whole and inner and outer retina were measured. MfERG N1 and P1 implicit times (ITs), and N1-P1 response amplitude densities (RADs), were measured from concentric rings (R) with increasing foveal eccentricity: 0–5° (R1), 5–10° (R2), 10–15° (R3), 15–20° (R4), 20–25° (R5), and from retinal sectors (superior, nasal, inferior and temporal) between 0–15° and 0–25°. In the MS-ON-P Group, mean mfERG RADs detected from R1 (0–5°) and from the central nasal sector (0–15°) were significantly reduced (p < 0.01) with respect to those of the Control, MS-noON and MS-ON-G Groups. No other significant differences between Groups for any mfERG parameters were found. All Sd-OCT measurements, apart from the inner retina macular volume in the central 1 mm, were significantly reduced in MS-ON-P patients compared to Controls. The functional impairment in the MS-ON-P Group was associated but not correlated with structural changes of the outer and inner retinal layers in corresponding retinal Areas and Sectors. Our results suggest that in MS, exclusively after ON with poor recovery of BCVA, the neurodegenerative process can induce dysfunctional mechanisms involving photoreceptors and bipolar cells of the fovea and of the more central nasal macular area.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

“…In all MS-ON-P patients, the macular morphology was evaluated by the RTVue-100 Sd-OCT device, following our recently published method [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis

Ziccardi

Barbano

Boffa

et al. 2020

JCM

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Retinal imaging with optical coherence tomography in multiple sclerosis: novel aspects

Olbert

Struhal

2022

Wien Med Wochenschr

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SummaryOptical coherence tomography (OCT) is of increasing interest in the clinical assessment of multiple sclerosis (MS) patients beyond the scope of clinical studies. In this narrative review, we discuss novel changes of OCT parameters during acute optic neuritis and the disease course of MS patients. OCT images document the changes of retinal layers during an episode of acute optic neuritis and can therefore provide valuable insights into the pathophysiology. Moreover, MS patients show progredient thinning of retinal layers throughout the disease. The thinning is accelerated through relapses as well as disease progression without relapse. The OCT parameters are also associated with clinical outcome parameters, including disability, cognitive function, and brain atrophy. The impact of disease-modifying therapies on OCT parameters is the subject of ongoing research and depends on the agent used. Additional data are still necessary before OCT parameters can be implemented in the clinical standard of care of MS patients.

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Multifocal Electroretinogram Photopic Negative Response: A Reliable Paradigm to Detect Localized Retinal Ganglion Cells’ Impairment in Retrobulbar Optic Neuritis Due to Multiple Sclerosis as a Model of Retinal Neurodegeneration

et al. 2022

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The measure of the full-field photopic negative response (ff-PhNR) of light-adapted full-field electroretinogram (ff-ERG) allows to evaluate the function of the innermost retinal layers (IRL) containing primarily retinal ganglion cells (RGCs) and other non-neuronal elements of the entire retina. The aim of this study was to acquire functional information of localized IRL by measuring the PhNR in response to multifocal stimuli (mfPhNR). In this case-control observational and retrospective study, we assessed mfPhNR responses from 25 healthy controls and from 20 patients with multiple sclerosis with previous history of optic neuritis (MS-ON), with full recovery of visual acuity, IRL morphological impairment, and absence of morpho-functional involvement of outer retinal layers (ORL). MfPhNR response amplitude densities (RADs) were measured from concentric rings (R) with increasing foveal eccentricity: 0–5° (R1), 5–10° (R2), 10–15° (R3), 15–20° (R4), and 20–25° (R5) from retinal sectors (superior-temporal (ST), superior-nasal (SN), inferior-nasal (IN), and inferior-temporal (IT)); between 5° and 20° and from retinal sectors (superior (S), temporal (T), inferior (I), and nasal (N)); and within 5° to 10° and within 10° and 20° from the fovea. The mfPhNR RAD values observed in all rings or sectors in MS-ON eyes were significantly reduced (p < 0.01) with respect to control ones. Our results suggest that mfPhNR recordings may detect localized IRL dysfunction in the pathologic condition of selective RGCs neurodegeneration.

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Morphological Outer Retina Findings in Multiple Sclerosis Patients With or Without Optic Neuritis

Cited by 6 publications

References 38 publications

Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis

Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis

Retinal imaging with optical coherence tomography in multiple sclerosis: novel aspects

Multifocal Electroretinogram Photopic Negative Response: A Reliable Paradigm to Detect Localized Retinal Ganglion Cells’ Impairment in Retrobulbar Optic Neuritis Due to Multiple Sclerosis as a Model of Retinal Neurodegeneration

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