Morphological markers of chromosomal instability as predictors of malignancy in pleural effusion
Phiza Aggarwal,
Uma Handa,
Ranjeev Bhagat
et al.
Abstract:BackgroundMalignancy in pleural effusion is an indication of poor prognosis. The distinction between malignant cells and reactive mesothelial cells in effusion cytology is sometimes difficult and requires ancillary techniques. Evaluation of morphological indicators of chromosomal instability (CI) like micronuclei (MN), chromatin bridging (CB), nuclear budding (NB), and multipolar mitosis (MM) on routine cytology smears is a promising tool to distinguish malignant from benign ascitic fluids. However, it has bee… Show more
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