Morphological, histological and radiological study of calcified placenta and its relation with fetal outcome

Goswami, Pushpa; Memon, Samreen; Pardeep, Kusum

doi:10.9790/0853-0768288

Cited by 6 publications

(4 citation statements)

References 15 publications

(10 reference statements)

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“…e mean placental weight difference was 63 gm at 95%, CI: 27.18-98.82 between the normal group and PIH group whereas between normal and abruption placenta groups the mean placental weight difference was 116.34 gm at 95% CI 83.95-148.73 (Table 5). A similar study done by Pushpa Goswami et al in 2013 reported less placental diameter in (66%) of cases in patients of PIH and abruption placenta [12]. According to Palaskar et al reduced placental weight in 77% [13].…”

Section: Discussionmentioning

confidence: 85%

Fetoplacental Weight Relationship in Normal Pregnancy and Pregnancy Complicated by Pregnancy-Induced Hypertension and Abruption of Placenta among Mothers Who Gave Birth in Southern Ethiopia, 2018

Mehare

Kebede

2020

Obstetrics and Gynecology International

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Introduction. Placenta is a complex multifunctional organ that maintains pregnancy and promotes normal fetal development. The fetal outcome is adversely influenced by pathological changes in the placenta because it is a mirror that reflects the intrauterine status of the fetus. Placental abnormalities are considered a leading cause of maternal and prenatal mortality. This study aimed to assess the fetoplacental weight relationship in pregnancy-induced hypertension and abruption placenta and compare with the normal one. Objective. This study designed to assess fetoplacental weight relationships in normal pregnancy and pregnancy complicated by pregnancy-induced hypertension and abruption of placenta among mothers who gave birth in Dilla University Referral Hospital, southern Ethiopia, 2018. Materials and Methods. Institution-based comparative cross-sectional study was used on 50 placentas from mothers with pregnancy-induced hypertension, 50 placentas from mothers with abruption of placenta, and 50 placentas from mothers with normal pregnancy (control) with an age range of 19–34 years. The weight of the placenta and newborn were taken and the fetoplacental ratio was calculated. Results. Placental index as well as the weight of the newborn shows statistically significant (p<0.001) difference in pregnancy-induced hypertension and abruption placenta group compared with the normal group. The mean of the fetoplacental ratio in the normal group was 5.52 ± 0.07, in pregnancy-induced hypertension was 5.15 ± 0.11, whereas the abruption placenta was 4.99 ± 0.82. Conclusion. Both PIH and abruption placenta were associated with remarkable changes in the placenta index such as small placental weight and diameter and results in different kinds of congenital anomalies and low birth weight of the baby. Hence, fetoplacental ratio was altered. The lowest fetoplacental ratio was 4.99 for abruption placenta, and the highest was for a normal group of the placenta which was 5.52. Therefore, an examination of the placenta before and after birth guarantees for feto-maternal health.

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Section: Discussionmentioning

confidence: 85%

Fetoplacental Weight Relationship in Normal Pregnancy and Pregnancy Complicated by Pregnancy-Induced Hypertension and Abruption of Placenta among Mothers Who Gave Birth in Southern Ethiopia, 2018

Mehare

Kebede

2020

Obstetrics and Gynecology International

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“…Dystrophic calcification of the placenta is evidence of placental senescence or degradation [22]. Calcium deposition noted in the villi and along the basement membrane strongly suggests uteroplacental insufficiency [23]. Syncytial nuclear aggregates are syncytiotrophoblast nuclei in clusters that can be found in sprouts, knots, and bridges.…”

Section: Discussionmentioning

confidence: 99%

An Objective Histopathological Scoring System for Placental Pathology in Pre-Eclampsia and Eclampsia

Donthi

Malik

Mohamed

et al. 2020

Cureus

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Background and objective Pre-eclampsia and eclampsia are common complications in pregnancy, and they lead to uteroplacental vascular insufficiency. More than 38% of pregnant women succumb to seizures without meeting the clinical criteria for pre-eclampsia or eclampsia. This highlights the importance of a confirmatory diagnosis of preeclampsia or eclampsia using the histopathological changes seen in the placenta. Hence, the present study aimed to validate an objective histopathological scoring system of the placenta for an appropriate diagnosis of pre-eclampsia or eclampsia. Material and methods In this prospective study spanning two years, 50 cases of pre-eclampsia/eclampsia and 50 control subjects with normal placenta were included. The histomorphological changes in the placenta were examined for both groups and a scoring system was formulated to assess the severity of pre-eclampsia/eclampsia syndrome. A maximum score of 2 and a minimum score of 0 was assigned for maternal floor infarcts, calcification, villous basement membrane thickening, and fibrin deposition. Syncytial knots were assigned a minimum score of 0 and a maximum score of 1. The association of various placental histopathological variables with a clinical diagnosis of pre-eclampsia, eclampsia, and control was analyzed using the chisquared/Fisher's exact test. A one-way analysis of variance (ANOVA) test was used for comparing objective histopathological scores between pre-eclampsia, eclampsia, and control groups. A p-value of less than 0.05 was considered to be statistically significant. Results We found a significant association between each histopathological parameters of the placenta, including fibrin deposition, maternal floor infarction, calcification, villous basement membrane thickening, and syncytial knots, and clinical diagnosis of pre-eclampsia, eclampsia, and control groups. A median score of 2 significantly correlated with the normal group, while median scores of 4 and 6 correlated with pre-eclampsia and eclampsia respectively. Conclusion This comprehensive scoring system can be a basis for validating reporting patterns of the placenta in preeclampsia and eclampsia patients, as well as other disorders related to maternal uteroplacental insufficiency.

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“…The finding of this study was steady with those studies conducted by Kazzi GM et al, Pushpa Goswami et al, Yaoundé Central Hospital, Cameroon where the frequency of grade two and above level of calcification among placentas were about six to thirty-one. [12][13][14] In the current study, efforts were made to make out the determinants of grade two and above level of calcification among placentas at Dilla University Referral Hospital. Educational status, parity, PIH, smoking, anemia, and abruption placenta were identified as determinants of grade two and above level of calcification.…”

Section: Discussionmentioning

confidence: 99%

“…This finding was comparable with study conducted at Liaquat University of medical and health sciences, Pakistan. 13 This could be explained by the fact that a high proportion of abruption placenta might be caused by retro-placental fibromyoma which might lead to extensive nodules on the surface of the placenta.…”

Section: Discussionmentioning

confidence: 99%

Determinants of calcified placenta and its association with fetal outcome among mothers who gave birth in Southern Ethiopia, 2018

Alemayehu¹,

Bayile²

2019

Int J Res Med Sci

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Background: Placenta is a complex multifunctional organ that maintains pregnancy and promotes normal fetal development. Fetal outcome is adversely influenced by pathological changes in placenta because it is a mirror which reflects intrauterine status of fetus. Placental abnormalities are considered as leading cause of maternal and perinatal mortality. Objective of the study was to assess determinants of calcified placenta and its association with fetal outcomes.Methods: Institutional based unmatched case-control study was conducted on 213 placentas from mothers who gave birth at Dilla university referral hospital with an age range of 19-34 years. Calcifications were assessed radiologically and graded according to Grannum. Bivariate logistic regression analysis was identified and fitted to the multiple logistic regression analysis to identify the independent effects of each variable to the outcome variable. Chi-square test was used to find the potential association between grade two and above levels of calcification and fetal outcomes.Results: Total 213 singles parturient with their placenta above 37 weeks gestational age were included. The likelihood of developing grade two and above level of calcification associated with the following variables: educational status (OR=3.134; 95%CI: 1.208, 8.135),parity (OR 3.125; 95% CI: 1.354, 7.213) ,maternal anemia (OR 6.834;95%C: I2.626,17.803), smoking (OR 6.343;95% CI: 2.624,15.334), abruption (OR 6.046;95% CI: 2.392,15.277), and pregnancy- induced hypertension (OR 4.868 ;95% CI: 2.095,11.354). In this study, neonatal outcomes in grade II and above level of calcification were poorer than grade I and bellow level of calcification in chi-square association test.Conclusions: Grade II and above level of placental calcification (case) was significantly associated with maternal pregnancy-induced pathologies, number of parity, maternal educational status, and results in different kind of anomalies, maternal and neonatal mortality. Therefore, the practice of placental examination before and after birth guarantees for feto-maternal wellbeing.

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Morphological, histological and radiological study of calcified placenta and its relation with fetal outcome

Cited by 6 publications

References 15 publications

Fetoplacental Weight Relationship in Normal Pregnancy and Pregnancy Complicated by Pregnancy-Induced Hypertension and Abruption of Placenta among Mothers Who Gave Birth in Southern Ethiopia, 2018

Fetoplacental Weight Relationship in Normal Pregnancy and Pregnancy Complicated by Pregnancy-Induced Hypertension and Abruption of Placenta among Mothers Who Gave Birth in Southern Ethiopia, 2018

An Objective Histopathological Scoring System for Placental Pathology in Pre-Eclampsia and Eclampsia

Determinants of calcified placenta and its association with fetal outcome among mothers who gave birth in Southern Ethiopia, 2018

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