Morphological, histological, and chemical analysis of first permanent molars with molar incisor malformation

Charisi, C; Kodonas, Konstantinos; Keklikoglou, Kleoniki; Arhakis, Aristidis; Arapostathis, Konstantinos; Kotsanos, Nikolaos

doi:10.1007/s40368-022-00723-9

Cited by 6 publications

(10 citation statements)

References 23 publications

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“…Histologic and microCT investigations following extraction of the symptomatic teeth for Child 5 highlighted porous communications and channels extending through dentine and connecting the pulp to the external surface of the tooth root. These findings are not only consistent with but also expand on the previous studies using microCT to describe the morphology of MRIM 3,20 . The source of odontogenic pain in children with MRIM may be from microcracks or microporosities 21,22 .…”

Section: Discussionsupporting

confidence: 89%

“…These findings are not only consistent with but also expand on the previous studies using microCT to describe the morphology of MRIM. 3,20 The source of odontogenic pain in children with MRIM may be from microcracks or microporosities. 21,22 The current study yields information that may explain the ingress of microorganisms from the oral environment that can utilize the tract or communication with the pulp, causing pulpitis and potentially necrosis.…”

Section: Microct Evaluation Of Extracted Molar Teethmentioning

confidence: 99%

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Prevalence and morphological features of molar‐root incisor malformation in children attending a specialist paediatric dental unit

Jensen

Smart

Lee

et al. 2023

Int J Paed Dentistry

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BackgroundMolar‐root incisor malformation (MRIM) is a rare dental anomaly featuring constricted cervical margins and tapered, narrow root and pulp morphology, often associated with severe toothache and infection.AimThe aim of this study was to determine the prevalence of MRIM in children seen in a specialist paediatric dental unit of a tertiary referral hospital and to describe the characteristics of affected individuals.DesignThis study was an audit of children attending from November 2020 to November 2021. Radiographs were used to identify individuals with MRIM, and clinical data were collated. In addition, histology and microcomputed tomography (microCT) imaging were performed on teeth extracted from an affected individual.ResultsThe prevalence of MRIM was five cases of 1054 children examined (0.47% or 1:210). The permanent first molars were affected in all five children and the primary second molars in two children; all children had medical comorbidities and multiple exposures to general anesthesia before 4 years of age. In addition, histological and microCT analyses displayed numerous microchannels connecting the pulp chamber to the external surface of the tooth at the furcation.ConclusionsMolar‐root incisor malformation is an uncommon dental anomaly affecting paediatric patients with multiple comorbidities and is characterized by porosities extending from the pulp chamber to the external tooth surface, predisposing the risk of bacterial ingress from the oral cavity into the pulp chamber. Early detection may prevent atypical odontogenic facial pain and infection.

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Section: Discussionsupporting

confidence: 89%

Section: Microct Evaluation Of Extracted Molar Teethmentioning

confidence: 99%

Prevalence and morphological features of molar‐root incisor malformation in children attending a specialist paediatric dental unit

Jensen

Smart

Lee

et al. 2023

Int J Paed Dentistry

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“…10,11 As a result of microcomputed tomography examination of 5 permanent first molars diagnosed with MIM, abnormal osteodentin-like hard tissue was detected. 12 In our patient, mandibular first molars were affected by the anomaly more than maxillary molars. In all reported cases, permanent mandibular first molars were affected, and in the vast majority of individuals, all four first molars were affected by this anomaly.…”

Section: Discussionmentioning

confidence: 52%

Molar-Incisor Malformation in a Pediatric Patient on Chemotherapy Treatment

İMAMOĞLU¹,

Karaçay²,

YILDIRIM³

et al. 2023

Turkiye Klinikleri J Case Rep

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ABS TRACT Certain chemotherapeutic agents used for malignancies in early childhood may cause abnormal tooth and root development. The panoramic examination of a patient who received chemotherapy for hepatoblastoma at the age of 18 months showed maxillary and mandibular first molars with clinically normal-looking crowns and insufficient root development, which were diagnosed with molar-incisor malformation (MIM). The review of the patient's medical file revealed that the chemotherapeutic agents causing the root anomaly were the combination of doxorubicin and cisplatin. The aim of this case report is to evaluate the relationship between MIM, and multiple chemotherapeutic agents used in early childhood.

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“…However, the roots are pointed and, on radiological examination, are characterized by apical and conical constrictions [ 6 , 8 ]. Teeth are usually mobile; they often undergo the formation of abscesses, granulomas, and cysts and can fall out prematurely [ 9 , 10 , 11 ]. The pulp chambers do not fill in before eruption in DD-II, while the aberrant formation of dentin can cause partial or total obliteration of the pulp in DD-I [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Further differential diagnoses are posed with diseases that have radiological and/or clinical signs similar to DD-I, including the different types of dentinogenesis imperfecta and with the following conditions causing premature tooth loss: Kostmann syndrome; cyclic neutropenia; Chediak–Hegashi syndrome; cell histiocytosis Langerhans syndrome; Papillon–Lefèvre syndrome; hypophosphatasia; and vitamin D-resistant rickets [ 6 , 7 , 11 , 13 , 15 , 16 , 17 ]. DD-I is caused by the upregulation or downregulation of many genes involved in odontogenesis (Dspp, Dmp1, Runx2, Pax9, Bmp2, Dlx2, vPS4B, Ssuh2, and SMOC2) [ 13 , 14 , 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Type I Dentin Dysplasia: The Literature Review and Case Report of a Family Affected by Misrecognition and Late Diagnosis

Putrino,

Caputo,

Galeotti

et al. 2023

Medicina

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Background and Objectives: Type I dentin dysplasia (DD-I) is a rare genetic disorder with autosomal dominant or recessive inheritance at risk of late or long-misunderstood diagnosis because the teeth, compared to other degenerative dentin diseases, do not have coronal defects and/or alterations but only at the root level (absent, conical, pointed roots, and obliterated pulp canals). The first radiographic suspicion often occurs only in case of sudden mobility and/or abscesses of the permanent teeth. Genetic tests confirm the diagnosis. Case Presentation: This case report describes the oral and radiographic characteristics of two siblings, 12 and 10 years old, a male and a female, at an early age affected by DD-I, whose diagnosis was made for a first orthodontic visit. The father and the older child had already undergone dental and orthodontic treatments, respectively, without the disease being suspected by the dentist. Results: Genetic tests support the diagnosis of DD-I. Following the diagnosis, the patients began a process of close periodic checks every 3–4 months to monitor their situation. The male child lost upper lateral incisors, which were then replaced with a light nylon removable prosthesis. Conclusions: The ability to recognize the radiographic features characteristic of DD-I is very important to avoid prejudicial diagnostic delays and to be able to plan the long-term treatment of these patients better, especially when the pathology was primarily misrecognized in the family.

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Morphological, histological, and chemical analysis of first permanent molars with molar incisor malformation

Cited by 6 publications

References 23 publications

Prevalence and morphological features of molar‐root incisor malformation in children attending a specialist paediatric dental unit

Prevalence and morphological features of molar‐root incisor malformation in children attending a specialist paediatric dental unit

Molar-Incisor Malformation in a Pediatric Patient on Chemotherapy Treatment

Type I Dentin Dysplasia: The Literature Review and Case Report of a Family Affected by Misrecognition and Late Diagnosis

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