Morphological features of the cornea in eyes with pseudophakic bullous keratopathy and Fuchs endothelial corneal dystrophy

Fisenko, N V; Труфанов, С В; Демура, Т. А.

doi:10.17116/oftalma202213801131

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Automatic segmentation algorithms also make it possible to measure the individual corneal layers and display them as color-coded thickness maps in their different localizations (Figure 1) [12]. OCT allows for an analysis of the changes in the corneal structure of FECD eyes and eyes treated with DMEK [13][14][15]. effective than previous surgical techniques, as DMEK is associated with a faster visual recovery and improved refractive and visual outcomes, as well as fewer graft rejections and postoperative supplemental medication [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Automatic segmentation algorithms also make it possible to measure the individual corneal layers and display them as colorcoded thickness maps in their different localizations (Figure 1) [12]. OCT allows for an analysis of the changes in the corneal structure of FECD eyes and eyes treated with DMEK [13][14][15]. Several studies have investigated the impact of DMEK on corneal tissue on a structural scale.…”

Section: Introductionmentioning

confidence: 99%

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Descemet Membrane Endothelial Keratoplasty (DMEK) Reduces the Corneal Epithelial Thickness in Fuchs’ Patients

Storp¹,

Lahme²,

Al-Nawaiseh³

et al. 2023

JCM

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Fuchs’ endothelial corneal dystrophy (FECD) is the occurrence of corneal edema due to endothelial cell dystrophy. Descemet membrane endothelial keratoplasty (DMEK) is considered to be the gold standard of treatment. The aim of this study was to investigate the changes in the corneal epithelial thickness of FECD patients before and after DMEK and to compare these results with a healthy control cohort. In this retrospective analysis, 38 eyes of patients with FECD that were treated with DMEK and 35 healthy control eyes received anterior segment optical coherence tomography (OCT; Optovue, XR-Avanti, Fremont, CA, USA). The corneal epithelial thicknesses in different locations were analyzed and compared between the preoperative, postoperative, and control cohorts. The median follow-up time was 9 months. There was a significant degression of the mean epithelial thickness after DMEK in the central, paracentral, and mid-peripheral zones (p < 0.01) of the cornea. The total corneal thickness and stromal thickness decreased significantly as well. No significant differences were observed between the postoperative and control cohorts. In conclusion, the FECD patients had an increased epithelial thickness compared to the healthy controls, which decreased significantly after DMEK and reached thickness levels comparable to those of healthy control eyes. This study emphasized the importance of distinguishing between the corneal layers in anterior segment pathologies and surgical procedures. Moreover, it accentuated the fact that the structural alterations in FECD extend beyond the corneal stroma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Descemet Membrane Endothelial Keratoplasty (DMEK) Reduces the Corneal Epithelial Thickness in Fuchs’ Patients

Storp¹,

Lahme²,

Al-Nawaiseh³

et al. 2023

JCM

View full text Add to dashboard Cite

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The Descemet Membrane Endothelial Keratoplasty (DMEK) “Wave Maneuver”

Lavy

Erdinest

Katzir

et al. 2022

JCM

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A novel technique for Descemet membrane endothelial keratoplasty (DMEK) graft handling and centration without the endothelium touching the posterior part of the anterior chamber (AC), is presented here. It is particularly suitable for vitrectomized eyes, deep AC, and AC intraocular lenses (ACIOLs), potentially reducing surgery time and endothelial cell loss during surgery. This retrospective interventional case series includes 27 eyes with complex ocular pathology. All utilized a “Wave maneuver” to center an early elevated graft without completing graft centration on the bottom of the AC. Successful graft attachment and centration were evaluated intra and post-operatively. Best-corrected visual acuity (BCVA), central corneal thickness (CCT), and donor endothelial cell density (ECD) were measured pre-operatively, and three and six months post-operatively. DMEK grafts were successfully attached and centered in all cases. No maneuver-related complications were observed intraoperatively. BCVA improved from a pre-operative 0.2 ± 0.63, to 0.43 ± 0.49 and 0.76 ± 0.51 at the three- and six-month follow-ups, respectively (p < 0.01). CCT decreased from a pre-operative 742 ± 118, to 546 ± 87 and 512 ± 67 at three and six months, respectively (p < 0.01). ECD decreased from 2878 ± 419 cells/mm2 to 1153 ± 466 cells/mm2 at three and six months, respectively (p < 0.01). The “Wave maneuver” may be very beneficial in DMEK cases where the AC is either very deep or the bottom of the AC is compromised. The “Wave maneuver” learning curve was brief.

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Morphological features of the cornea in eyes with pseudophakic bullous keratopathy and Fuchs endothelial corneal dystrophy

Cited by 2 publications

References 23 publications

Descemet Membrane Endothelial Keratoplasty (DMEK) Reduces the Corneal Epithelial Thickness in Fuchs’ Patients

Descemet Membrane Endothelial Keratoplasty (DMEK) Reduces the Corneal Epithelial Thickness in Fuchs’ Patients

The Descemet Membrane Endothelial Keratoplasty (DMEK) “Wave Maneuver”

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