Morphological effects of coronary balloon angioplasty in vivo assessed by intravascular ultrasound imaging.

Honye, Junko; Mahon, Donald J.; Jain, Ashit; White, Christopher J.; Ramee, Stephen R.; Wallis, James; Al-Zarka, Amer M.; Tobis, Jonathan M.

doi:10.1161/01.cir.85.3.1012

Cited by 312 publications

(103 citation statements)

References 36 publications

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“…We also evaluated plaque quality, such as eccentricity, calcification and lipid pool in plaque formation. Eccentricity was identified when the minimum dimension of plaque thickness/dimension on the other side of plaque thickness in the maxi plaque area was less than 0.5 17) . Calcification was defined when a high echo area with back reflection was detected and a lipid pool was defined as when an echo lucent zone was detected during the observation period.…”

Section: Angiographic and Ivus Studymentioning

confidence: 99%

Relationship between Metabolic Syndrome and Early Stage Coronary Atherosclerosis

Hatori

Takahashi

Iizuka

et al. 2007

JAT

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Aim: Recent clinical studies using intra-vascular ultrasound have clarified that coronary artery plaque already exists in subjects with normal coronary artery which is diagnosed by coronary angiography; furthermore, culprit lesion on acute coronary syndrome often occurs in mild to moderate angiographical stenotic lesion. The aim of this study is to clarify relationship between metabolic syndrome and early stage coronary atherosclerosis using a 3-dimensional intra-vascular ultrasound. Methods: 70 subjects with normal coronary artery diagnosed by coronary angiography were enrolled. Proxymal range of left anterior descending coronary artery was observed by intra-vascular ultrasound using autopullback methods. Results: Subjects with metabolic syndrome had significantly high percent plaque volume (31 8% vs 21 8%, p 0.0001) and frequently detected abnormal plaque quality such as eccentricity, calcification and lipid pool into plaque than those without metabolic syndrome. Multivariate analysis showed that serum adiponectin concentration was the most strongest variable for percent plaque volume (t value 3.0, p 0.01). On the other hand, subjects with hypoadiponectinemia were detected high incidence of mild calcification into plaque.

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Section: Angiographic and Ivus Studymentioning

confidence: 99%

Relationship between Metabolic Syndrome and Early Stage Coronary Atherosclerosis

Hatori

Takahashi

Iizuka

et al. 2007

JAT

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“…1 More than 80% of coronary lesions are calcified, 2 and calcium deposits are often associated with unesterified cholesterol. 3 Two very recent studies, on the in vivo 4 and ex vivo 5 detection of calcium deposits in coronary arteries, have shown that calcification is correlated with atherosclerotic plaque burden and that noninvasive detection of calcification may have predictive value in the development of subsequent coronary events.…”

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confidence: 99%

Noncollagenous Bone Matrix Proteins, Calcification, and Thrombosis in Carotid Artery Atherosclerosis

Bini

Mann

Kudryk

et al. 1999

ATVB

141

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Abstract-Advanced atherosclerosis is often associated with dystrophic calcification, which may contribute to plaque rupture and thrombosis. In this work, the localization and association of the noncollagenous bone matrix proteins osteonectin, osteopontin, and osteocalcin with calcification, lipoproteins, thrombus/hemorrhage (T/H), and matrix metalloproteinases (MMPs) in human carotid arteries from endarterectomy samples have been determined. According to the recent American Heart Association classification, 6 of the advanced lesions studied were type V (fibroatheroma) and 16 type VI (complicated 4 and ex vivo 5 detection of calcium deposits in coronary arteries, have shown that calcification is correlated with atherosclerotic plaque burden and that noninvasive detection of calcification may have predictive value in the development of subsequent coronary events. 5 The molecular determinants regulating extracellular matrix calcification have yet to be identified. Recent studies have shown that noncollagenous bone matrix proteins such as osteonectin, osteocalcin, and osteopontin are also found in atherosclerotic vessels and may regulate dystrophic calcification. For example, osteonectin (SPARC) has been identified in vessel wall cells 6 and platelets 7 and participates in the regulation of bone mineralization, 8 cell migration/proliferation, 9 and remodeling of extracellular matrix. 10 -12 Recently, it has been shown that osteonectin binds to plasminogen, 13 increases its activation and binding to collagen, 13 and induces the expression of type 1 plasminogen activator inhibitor in endothelial cells (ECs). 14 That suggests a role for osteonectin in both the degradation of extracellular matrix and the regulation of fibrinolysis. Moreover, osteonectin upregulates the expression of matrix metalloproteinases (MMPs) in cultured fibroblasts. 15 Previous studies have implicated MMPs in destabilization and rupture of atherosclerotic plaques, 16 -19 and we recently showed that both fibrinogen and cross-linked fibrin, proteins known to be associated with both early and complicated plaques, can be degraded by MMP-2,

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“…ntracoronary ultrasound (ICUS) has provided insights into the mechanism of percutaneous coronary interventions [1][2][3][4] as well as the pattern and mechanism of restenosis. [5][6][7] Prior studies have demonstrated that ICUS provides information not generated by angiography 8 -11 and that the use of sonographic measurements of vascular dimensions improves angiographic results.…”

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confidence: 99%

Ultrasound-Guided Strategy for Provisional Stenting With Focal Balloon Combination Catheter

et al. 2000

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Background-Intracoronary ultrasound (ICUS) has provided insights into vascular pathology and interventional therapy.The Strategy for ICUS-Guided PTCA and Stenting (SIPS) trial tested the hypothesis that routine ICUS guidance of coronary interventions improves outcome. Methods and Results-A single-center consecutive-patient randomized design (with 6-month angiographic and 2-year clinical follow-up) was used. Consecutive patients (no chronic total occlusions or emergency procedures) were randomized to ICUS-guided provisional stenting or standard angiographic guidance. Quantitative angiographic minimal lumen diameter (MLD), angiographic restenosis, clinically driven target lesion revascularization, and major adverse cardiac events (MACEs) were evaluated.

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Morphological effects of coronary balloon angioplasty in vivo assessed by intravascular ultrasound imaging.

Cited by 312 publications

References 36 publications

Relationship between Metabolic Syndrome and Early Stage Coronary Atherosclerosis

Relationship between Metabolic Syndrome and Early Stage Coronary Atherosclerosis

Noncollagenous Bone Matrix Proteins, Calcification, and Thrombosis in Carotid Artery Atherosclerosis

Ultrasound-Guided Strategy for Provisional Stenting With Focal Balloon Combination Catheter

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